Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease

Archives of Neurology

Volumn 54, Issue 10, 1997, Pages 1289-1292

  Clatworthy, Anne E ^a   Gomez Isla, Teresa ^a   Rebeck, G William ^a   Wallace, R B ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0030882168     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.1997.00550220087019     Document Type: Article

References (20)

1. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
2. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
3. Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM. Apolipoprotein Econtaining high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem. 1996;271: 30121-30125.
4. Bellosta S, Nathan BP, Orth M, Dong L, Mahley RW, Pitas RE. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem. 1995;270:27063-27071.
5. Holtzman DM, Pitas RE, Kilbridge J, et al. Low density lipoprotein receptorrelated protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci U S A. 1995; 92:9480-9484.
6. Strickland DK, Kounnas MZ, Argraves WS. LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J. 1995;9: 890-898.
7. Kounnas M, Moir R, Rebeck G, et al. LDL receptor-related protein, a multifunctional apolipoprotein E receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 1995;82:331-340.
8. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 1993; 11:575-580.
9. 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann Neurol. 1995;37:211-217.
10. 2-macroglobulin receptor (A2MR)/LDL receptor-related protein (LRP) gene. Hum Mol Genet. 1994;3:215.
11. Hyman B, Gomez-lsla T, Briggs M, et al. Apolipoprotein E and cognitive changes in an elderly population. Ann Neurol. 1996;40:55-66.
12. Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Psychiatr Soc. 1975;23:433-441.
13. Gomez-lsla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol. 1997;41:17-24.
14. Hixson J, Vernier D. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res. 1990;31:545-548.
15. Roses A, Devlin B, Conneally P, et al. Measuring the genetic contribution of APOE in late-onset Alzheimer disease (AD). Am J Hum Genet. 1995;57(suppl):A202.
16. Okuizumi K, Onodera O, Namba Y, et al. Genetic association of very low density lipoprotein (VLDL) receptor gene locus with sporadic Alzheimer's disease. Nat Genet. 1995;11:207-209.
17. Chung H, Roberts CT, Greenberg S, et al. Lack of association of trinucleotide repeat polymorphisms in the very-low-density lipoprotein receptor gene with Alzheimer's disease. Ann Neurol. 1996;39:800-803.
18. Okuizumi K, Onodera O, Seki K, et al. Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease. Ann Neurol. 1996;40:251-254.
19. Pritchard ML, Saunders AM, Gaskell PC, et al. No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer's disease in American Caucasians. Neurosci Lett. 1996;209:105-108.
20. Kang DE, Saitoh T, Chen X, et al. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with lateonset Alzheimer's disease. Neurology. 1997;49:56-61.