Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene

Neuroscience Letters

Volumn 244, Issue 2, 1998, Pages 65-68

  Kamboh, M Ilyas ^a   Ferrell, Robert E ^a   DeKosky, Steven T ^a,b  

^a GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Association studies; Low density lipoprotein receptor related protein; Sporadic late onset

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; DNA POLYMORPHISM; FEMALE; GENE LOCATION; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL;

AGE OF ONSET; AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; EXONS; FEMALE; GENOTYPE; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MALE; MICROSATELLITE REPEATS; POINT MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; REFERENCE VALUES;

EID: 0032513229     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00141-4     Document Type: Article

References (20)

1. Beisiegel U., Weber W., Ihrke G., Herz J., Stanley K. The LDL-receptor-related protein LRP, is an apolipoprotein E binding protein. Nature. 341:1989;162-164.
2. Fallin D., Gauntlett A., Scibelli P., Cai X., Duara R., Gold M., Crawford F., Mullan M. No association between the VLDL-R gene and late-onset Alzheimer's disease nor interaction with the APOE gene in population-based and clinic samples. Genet. Epidemiol. 14:1997;299-305.
3. Fallin D., Kundtz A., Town T., Gauntlett A.C., Dura R., Barker W., Crawford F., Mullan M. No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample. Neurosci. Lett. 233:1997;145-147.
4. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijin C.M. (for the Alzheimer Disease Meta Analysis Consortium), Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. J. Am. Med. Assoc. 278:1997;1345-1356.
5. 1-antichymotrypsin in Alzheimer disease. Genomics. 33:1996;53-56.
6. Hardy J. Molecular genetics of Alzheimer's disease (review). Acta. Neurol. Scand. (Suppl.). 165:1996;13-17.
7. Harris M., Sanghera D.K., Kamboh M.I. Two new alleles in the tetranucleotide repeat polymorphism in the LDL-receptor-related protein (LRP) gene. Clin. Genet. 50:1996;54-55.
8. Harris, M.R., Bunker, C.H., Hamman, R.F., Sanghera, D.K., Aston, C.E. and Kamboh, M.I., Racial differences in the distribution of a low density lipoprotein receptor-related protein (LRP) polymorphism and its association with serum lipid and apolipoprotein levels, Atherosclerosis, (1998) in press.
9. Holtzman D.M., Pitas R.E., Kilbridge J., Nathan B., Mahley R.W., Bu G., Schwartz A.L. Low density lipoprotein receptor related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA. 92:1995;9480-9484.
10. Kamboh M., Sanghera D., Ferrell R., DeKosky S. APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nat. Genet. 10:1995;486-488.
11. Kamboh M.I., Aston C.E., Hamman R.F. The relationship of APOE polymorphism and cholesterol levels in normoglycemic and diabetic subjects in a biethnic population from the San Luis Valley. Colorado, Atherosclerosis. 112:1995;145-159.
12. Kang D.E., Saitoh T., Chen X., Xia Y., Masliah E., Hansen L.A., Thomas R.G., Thal L.J., Katzman R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein receptor, with late-onset Alzheimer's disease. Neurology. 49:1997;56-61.
13. Kounnas M., Moir R., Rebeck W., Bush A., Argraves S., Tanzi R., Hyman B., Strickland D. LDL receptor related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation. Cell. 82:1995;331-340.
14. Lendon C., Talbot C., Craddock N., Han S.W., Wragg M., Morris J., Goate A. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neurosci. Lett. 222:1997;187-190.
15. Okuizumi K., Onedera O., Namba Y., Ikeda K., Yamamoto T., Seki K., Ueki A., Nanko S., Tanaka H., Takahashi H., Oyanagi K., Mizusawa H., Kanazawa I., Tsuji S. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nat. Genet. 11:1995;207-209.
16. Rebeck G.W., Harr S.D., Strickland D.K., Hyman B.T. Multiple, diverse senile plaque associated proteins are ligands of an apolipoprotein receptor, the alpha 2 macroglobulin receptor/low density lipoprotein-related protein. Ann. Neurol. 37:1995;211-217.
17. Scott W., Yamaoka L., Locke P., Rosi B., Gaskell P., Saunders A., Conneally P., Small G., Farrer L., Growdon J., Roses A., Pericak-Vance M., Haines J. No association or linkage between an intronic polymorphism of presenillin-1 and sporadic or late-onset familial Alzheimer's. Genet. Epidemiol. 14:1997;307-315.
18. Wavrant-De Vriéze F., Pérez-Tur J., Lamert J.-C., Frigard B., Pasquier F., Delacourte A., Amouyel P., Hardy J., Chartier-Harlin M.-C. Association between the low density lipoprotein-related protein (LRP) and Alzheimer's disease. Neurosci. Lett. 227:1997;68-70.
19. Wragg, M., Hutton, M., Talbot, C. and the Alzheimer's disease collaborative group, Genetic association between intronic polymorphism in the presenilin 1 gene and late-onset Alzheimer's disease, Lancet, 347 (1996) 509-512.
20. 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E ε4 allele carriers. Ann. Neurol. 42:1997;115-117.