Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide

Journal of Experimental Medicine

Volumn 186, Issue 4, 1997, Pages 507-515

  Marušić, Suzana ^a   Tonegawa, Susumu ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; FREUND ADJUVANT; INTERLEUKIN 4; MYELIN BASIC PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; ENCEPHALOMYELITIS; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TRANSGENIC MOUSE;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNE TOLERANCE; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TH2 CELLS;

EID: 1842417149     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.4.507     Document Type: Article

References (47)

1. Zamvil, S.S., and L. Steinman. 1990. The T lymphocyte in experimental allergic enccphalomyelitis. Annu. Rev. Immunol. 8:579-621.
2. Zamvil, S., P. Nelson, J. Trotter, D. Mitchell, R. Knobler, R. Fritz, and L. Steinman. 1985. T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature (Lond.). 317:355-358.
3. Sakai, K., T. Namikawa, T. Kunishita, K. Yamanouchi, and T. Tabira. 1986. Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell lines and clones in euthymic and athymic mice. J. Immunol. 137:1527-1531.
4. Kuchroo, V.K., C.A. Martin, J.M. Gree, S.-T. Ju, R.A. Sobel, and M.E. Dorf. 1993. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol. 151:4371-4382.
5. Baron, J.L., J.A. Madri, N.H. Ruddle, G. Hashim, and C.A. Janeway, Jr. 1993. Surface expression of alpha-4 integrin by CD4 T cells is required for their entry into brain parenchyme. J. Exp. Med. 177:57-68.
6. Kennedy, M.K., D.S. Torrance, K.S. Picha, and K.M. Mahler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496-2505.
7. Lider, O., T. Reshef, E. Beraud, A. Ben-Nun, and I.R. Cohen. 1988. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science (Wash. DC). 239:181-183.
8. Vandenbark, A.A., G. Hashim, and H. Offner. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects aginst experimental autoimmune encephalomyelitis. Nature (Lond.). 341:541-544.
9. Higgins, P.J., and H.L. Weiner. 1988. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 140: 440-445.
10. Zaller, D.M., G. Osman, O. Kanagawa, and L. Hood. 1990. Prevention and treatmment of murine experimental allergic encephalomyelitis with T cell receptor Vβ-specific antibodies. J. Exp. Med. 171:1943-1955.
11. Steinman, L., J.T. Rosenbaum, S. Sriram, and H.O. McDevitt. 1981. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA. 78:7111-7114.
12. Gaur, A., B. Wiers, A. Liu, J. Rothbard, and G.G. Fathman. 1992. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science (Wash. DC). 258:1491-1494.
13. Smilek, D.E., D.C. Wraith, S. Hodkinson, S. Dwivedy, L. Steinman, and H.O. McDevitt. 1991. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA. 88:9633-9637.
14. Wraith, D.C., D.E. Smilek, D.J. Mitchell, L. Steinmann, and H.O. McDevitt. 1989. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell. 59:247-255.
15. Urban, J.L., S.J. Horvath, and L. Hood. 1989. Autoimmune T cells: immune recognition of normal and variant peptide epitopes and peptide-based therapy. Cell. 59:257-271.
16. Fosthuber, T., H.C. Yip, and P.V. Lehmann. 1996. Induction of TH1 and TH2 immunity in neonatal mice. Science (Wash. DC). 271:1728-1730.
17. Jenkins, M.K., and R.H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific unresponsiveness in vitro and in vivo. J. Exp. Med. 165: 302-319.
18. Lafaille, J.J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 78:399-408.
19. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 68:69-77.
20. Kopf, M., G. Le Gros, M. Bachmann, M.C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks TH2 cytokine responses. Nature (Lond.). 362:245-248.
21. Adachi, M., R. Watanabe-Fukunaga, and S. Nagata. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA. 90:1756-1760.
22. Eynon, E.E., and D.C. Parker. 1992. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131-138.
23. Day, M.J., A.G.D. Tse, M. Puklavec, S.J. Simmonds, and D.W. Mason. 1992. Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J. Exp. Med. 175:655-659.
24. Gammon, G., K. Dunn, N. Shastri, A. Oki, S. Wilbur, and E.E. Sercarz. 1986. Neonatal T cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature (Lond.). 319:413-415.
25. Russel, J.H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA. 90: 4409-4413.
26. Nicholson, L.B., J.M. Greer, R.A. Sobel, M.B. Lees, and V.K. Kuchroo. 1995. Altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 3:397-405.
27. Powrie, F., and R.L. Coffman. 1993. Cytokine regulation of T cell function-potential for therapeutic intervention. Immunol. Today. 14:270-274.
28. Miller, S.D., and W.L. Karpus. 1994. The immunopathogenesis and regualation of T cell mediated demyelinating diseases. Immunol. Today. 15:356-361.
29. O'Garra, A., and K. Murphy. 1993. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880-886.
30. Katz, J.D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science (Wash. DC). 268:1185-1188.
31. Sher, A., R.T. Gazzinelli, I.P. Oswald, M. Clerici, M. Kullberg, E.J. Perce, J.A. Berzofsky, T.R. Mosmann, S.L. James, H.C. Morse, III, and G.M. Sherer. 1992. Role of T-cell derived cytokines in the down-regulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 127:183-204.
32. Sadick, M.D., and F.P. Locksley. 1990. Cure of murine Leishmaniasis with anti-interleukin-4 monoclonal antibody. Evidence for a T-cell dependent, interferon gamma independent mechanism. J. Exp. Med. 171:115-127.
33. Paul, W.E., and R.A. Seder. 1994. Lymphocyte responses and cytokines. Cell. 76:241-251.
34. Punnonen, J., G. Aversa, B.G. Cocks, A.N. McKenzie, S. Menon, G. Zurawski, R. DeWaal Malefyt, and J.E. deVries. 1993. Interleukin-13 induces interleukin-4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA. 90:3730-3734.
35. Kearney, E.R., K.A. Pape, D.Y. Loh, and M.K. Jenkins. 1994. Visualization of peptide specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
36. Lafaille, J.J., F. Van de Keere, A.L. Hsu, J.L. Baron, W. Haas, C.S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific Th2 cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protecting them from the disease. J. Exp. Med. 186:307-312.
37. Powell, M.B., D. Mitchell, J. Lederman, J. Buckmeier, S.S. Zamvil, M. Graham, N.H. Ruddle, and L. Steinman. 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539-544.
38. Olsson, T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:245-268.
39. Peterson, J.D., W.J. Karpus, R.J. Clatch, and S.D. Miller. 1993. Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus. Eur. J. Immunol. 23:46-55.
40. DeWit, D., M. Van Machelan, M. Ryelandt, A.C. Figueredo, D. Abramovicz, M. Goldman, H. Bazin, J. Urbain, and O. Leo. 1992 The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes. J. Exp. Med. 175: 9-14.
41. Critchfield, J.M., M.K. Racke, J.C. Zuniga-Pflucker, B. Cannella, C.S. Raine, J. Goverman, andJ.M. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science (Wash. DC). 263:1139-1141.
42. Singer, G.G., and A.K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:365-371.
43. Falb, D., T.J. Briner, G.H. Sunshine, C.R. Bourque, M. Luqman, M.L. Gefter, and T. Kamradt. 1996. Peripheral tolerance in T cell receptor-transgenic mice: evidence for T cell anergy. Eur. J. Immunol. 26:130-135.
44. Van Parijs, L., A. Ibraghimov, and A.K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity. 4:321-328.
45. Schwartz, R.H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1-8.
46. Bhandoola, A., E.A. Cho, K. Yui, H.U. Saragovi, M.I. Greene, and H. Quill. 1993. Reduced CD3-mediated protein tyrosine phosporylation in anergic CD4+ and CD8+ T cells. J. Immunol. 151:2355-2367.
47. McCormack, J.E., J. Kappler, and P. Marrack. 1994. Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo. Proc. Natl. Acad. Sci. USA. 91: 2086-2090.