Laminin inhibits both Aβ40 and Aβ42 fibril formation but does not affect Aβ40 or Aβ42-induced cytotoxicity in PC12 cells

Neuroscience Letters

Volumn 266, Issue 2, 1999, Pages 85-88

  Monji, Akira ^a   Tashiro, Ken Ichiro ^b   Yoshida, Ichiro ^a   Kaname, Hitoshi ^a   Hayashi, Yoshihito ^b   Matsuda, Kazunori ^b   Tashiro, Nobutada ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

3 4,5 dimethylthiazol 2 yl 2,5 diphenyltetrazolium bromide; Alzheimer's disease; Amyloid protein; Cytotoxicity; Electron microscopy; Laminin; PC12 cells; Thioflavine T

Indexed keywords

AMYLOID BETA PROTEIN; LAMININ; TETRAZOLIUM; THIOFLAVINE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); COLORING AGENT; PEPTIDE FRAGMENT; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CYTOTOXICITY; DEGENERATIVE DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SENILE PLAQUE; ANIMAL; CELL STRAIN; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT;

AMYLOID BETA-PROTEIN; ANIMALS; CELL SURVIVAL; COLORING AGENTS; LAMININ; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0033531797     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00273-6     Document Type: Article

References (20)

1. Aksenova M.V., Aksenov M.Y., Butterfield D.A., Carney J.M. α-1-antichymotrypsin interaction with Aβ (1-40) inhibits fibril formation but does not affect the peptide toxicity. Neurosci. Lett. 211:1996;45-48.
2. Aksenov M.Y., Aksenova M.Y., Carney J.M., Butterfield D.A. α-1-antichymotrypsin interaction with Aβ (1-42) does not inhibit fibril formation but attenuates the peptide toxicity. Neurosci. Lett. 211:1996;117-120.
3. Aksenov M.Y., Aksenova M.Y., Butterfield D.A., Hensley K., Vigo-Pelfrey C., Carney J.M. Glutamate synthetase-induced enhancement of β-amyloid peptide Aβ (1-40) neurotoxicity accompanied by abrogation of fibril formation and Aβ fragmentation. J. Neurochem. 66:1996;2050-2056.
4. Bronfman F.C., Alvarez A., Morgan C., Inestrosa N.C. Laminin blocks the assembly of wild-type Aβ and the Dutch variant peptide into Alzheimer's fibrils. Amyloid. 5:1998;16-23.
5. Bronfman F.C., Garrido J., Alvarez A., Morgan C., Inestrosa N.C. Laminin inhibits amyloid-β-peptide fibrillation. Neurosci. Lett. 218:1996;201-203.
6. Bronfman F.C., Soto C., Tapia L., Tapia V., Inestrosa N.C. Extracellular matrix regulates the amount of the β-amyloid precursor protein and its amyloidogenic fragments. J. Cell. Physiol. 166:1996;360-369.
7. Forloni G., Lucca E., Angeretti N., Torre P.D., Salmona M. Amidation of β-amyloid peptide strongly reduced the amyloidogenic activity without alteration of neurotoxicity. J. Neurochem. 69:1997;2048-2054.
8. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods. 119:1989;203-210.
9. Ghanta J., Shen C.L., Kiessling L.L., Murphy R.M. A strategy for designing inhibitors of β-amyloid toxicity. J. Biol. Chem. 271:1996;29525-29528.
10. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., Klein W.L. Diffusible non-fibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA. 95:1998;6448-6453.
11. Luckenbill-Edds L. Laminin and the mechanism of neuronal outgrowth. Brain Res. Rev. 23:1997;1-27.
12. Monji A., Tashiro K., Yoshida I., Hayashi Y., Tashiro N. Laminin inhibits Aβ42 fibril formation in vitro. Brain Res. 788:1998;187-190.
13. Monji A., Tashiro K., Hayashi Y., Yoshida I., Tashiro N. The inhibitory effect of laminin 1 and synthetic peptides deduced from the sequence in the laminin α1 chain on Aβ40 fibril formation. Neurosci. Lett. 251:1998;65-68.
14. Morgan C., Garrido J. Laminin disaggregates amyloid β-fibrils. Neurobiol. Aging. 19:1998;S185.
15. Mürtomaki S., Risteri J., Risteri L., Koivisto U.M., Johansson S., Liesi P. Laminin and its neurite outgrowth-promoting domain in the brain of Alzheimer's disease and Down's syndrome patients. J. Neurosci. Res. 32:1992;261-273.
16. Neve R.L., Robakis N.K. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21:1998;15-19.
17. 1-42) and slowly sedimenting Aβ complexes that cause oxidative stress. Exp. Neurol. 136:1995;22-31.
18. Shearman M.S., Ragan C.I., Iversen L.L. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid mediated cell death. Proc. Natl. Acad. Sci. USA. 91:1994;1470-1474.
19. Soto C., Sigurdsson E.M., Morelli L., Kumar A., Castano E.M., Frangione B. β-Sheet breaker pepides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implication for Alzheimer's therapy. Nat. Med. 4:1998;822-826.
20. Webster S., Bradt B., Rogers J., Cooper N. Aggregation-state dependent activation of the classical complement pathway by the amyloid β peptide. J. Neurochem. 69:1997;388-398.