Dose-dependent metabolism of benzene in hamsters, rats, and mice

Toxicological Sciences

Volumn 44, Issue 1, 1998, Pages 14-21

  Mathews, James M ^a   Etheridge, Amy S ^a   Matthews, H B ^b  

^a RTI INTERNATIONAL   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 BENZENETRIOL; ACETYLCYSTEINE DERIVATIVE; BENZENE; CATECHOL; CORN OIL; DRUG METABOLITE; GLUCURONIDE; HYDROQUINONE; MUCONALDEHYDE; MUCONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISPOSITION; DRUG URINE LEVEL; HAMSTER; INTRAGASTRIC DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENCE; XENOBIOTIC METABOLISM;

EID: 0031820972     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2474     Document Type: Article

References (36)

1. Barale, R., Marrazzini, A., Betti, C., Vangeliste, V., Loprieno, N., and Barrai, I. (1990). Genotoxicity of two metabolites of benzene: Phenol and hydroquinone show strong synergistic effects in vivo. Mutat. Res. 244, 15-20.
2. Bechtold, W. E., Willis, J. K., Sun, J. D., Griffith, W. C., and Reddy, T. V. (1992). Biological markers of exposure to benzene-S-phenylcysteine in albumin. Carcinogenesis 13, 1217-1220.
3. Behringer, H., and Fackler, E. (1949). Eine einfache Synthese der racemischen Mercaptursauren. Justus Liebigs Ann. Chem. 564, 73-78.
4. Chem. Eng. News, June 24, p. 41 (1996).
5. Cox, L. A. (1991). Biological basis of chemical carcinogenesis: Insights from benzene. Risk Anal. 11, 453-464.
6. Eastmond, D. A., Smith, M. T., and Irons, R. D. (1987). An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene. Toxicol. Appl. Pharmacol. 91, 85-95.
7. Guy, R. L., Hu, P., Witz, G., Goldstein, B. D., and Snyder, R. (1991). Depression of iron uptake into erythrocytes in mice by treatment with the combined benzene metabolites p-benzoquinone, muconaldehyde and hydroquinone. J. Appl. Toxicol. 11, 443-446.
8. Henderson, R. F. (1996). Species differences in the metabolism of benzene. Environ. Health Perspect. 104(Suppl. 6), 1173-1175.
9. Henderson, R. F., Sabourin, P. J., Bechtold, W. E., Griffith, W. C., Medinsky, M. A., Birnbaum, L. S., and Lucier, G. (1989). The effect of dose, dose rate, route of administration and species on tissue and blood levels of benzene metabolites. Environ. Health Perspect. 82, 9-17.
10. Huff, J. E., Haseman, J. K., DeMarini, D. M., Eustis, S., Maronpot, R. R., Peters, A. C., Persing, R. L., Chrisp, C. E., and Jacobs, A. C. (1989). Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ. Health Perspect. 82, 125-163.
11. Infante, P., Rinsky, R., Wagoner, J., and Young, R. (1977). Leukemia in benzene workers. Lancet 2, 76-78.
12. Johansson, I., and Ingelman-Sundberg, M. (1988). Benzene metabolism by ethanol-, acetone- and benzene-inducible cytochrome P450 (IIE1) in rat and rabbit liver microsomes. Cancer Res. 48, 5387-5390.
13. Koop, D. R., Laethem, C. L., and Schnier, G. G. (1989). Identification of ethanol-inducible P450 isozyme 3a, P45011E1, as a benzene and phenol hydroxylase. Toxicol. Appl. Pharmacol. 98, 278-288.
14. Krause, C., Mailahn, W., Nagel, R., Schulz, C., Seifert, B., and Ullrich, D. (1987). Occurrence of volatile organic compounds in the air of 500 homes in the Federal Republic of Germany. In Proceedings of the 4th International Conference on Indoor Air Quality and Climate (B. Seifert, H. Esdorn, M. Fischer, H. Ruden, and J. Wegner, Eds.), Vol. 1, pp. 102-106. Institute for Soil, Water, and Air Hygiene, Berlin.
15. Lebret, E., Van de Weil, H. J., Noij, D., Boleij, and J. S. M. (1986). Volatile hydrocarbons in Dutch homes. Environ. Int. 12, 323-332.
16. Lovern, M, R., Turner, M. J., Meyer, M., Kedderis, G .L., Bechtold, W. E., and Schlosser, P. M. (1997). Identification of benzene oxide as a product of benzene metabolism by mouse, rat, and human liver microsomes. Carcinogenesis 18, 1695-1700.
17. Mathews, J. M., Parker, M. K., and Matthews H. B. (1991). Metabolism and disposition of diethylene glycol. Drug Metab. Dispos. 19, 1066-1070.
18. Mathews, J. M., Raymer, J. H., Velez, G. R., Garner, C. E., and Bucher, J. R. (1996). The influence of cytochrome P450 enzyme activity on the composition and quantity of volatile organics expired in breath. Biomarkers 1, 196-201.
19. Medinsky, M. A., Sabourin, P. J., Lucier, G., Birnbaum, L. S., and Henderson, R. F. (1989). A physiological model for simulation of benzene metabolism by rats and mice. Toxicol. Appl. Pharmacol. 99, 193-206.
20. NTP (1986). Toxicology and Carcinogenesis Studies of Benzene in F344/N Rats and B6C3F1 Mice (Gevage Studies), Technical Report Series 289. National Toxicology Program, Research Triangle Park, NC.
21. Parke, D. V. (1996). Personal reflections of 50 years of study of benzene toxicology. Environ. Health Perspect. 104(Suppl. 6), 1123-1128.
22. Ronis, M. J. J., Lindros, K. O., and Ingelman-Sundberg, M. (1996). The cytochrome P4502E subfamily. In Cytochromes P450, Pharmacological and Toxicological Aspects (I. Ionnides, Ed.), pp. 211-239. CRC Press, Boca Raton, FL.
23. Rothman, N., Li, G.-L., Dosemeci, M., Bechtold, W. E., Marti, G. E., Wang, Y.-Z., Linet, M., Xi L.-Q., Lu, W., Smith, M. T., Titenko-Holland, N., Zhang, L.-P., Blot, W., Yin, S.-N., and Hayes, R. B. (1996). Hematotoxicity among Chinese workers heavily exposed to benzene. Am. J. Ind. Med. 29, 236-46.
24. Runion, H. E., and Scott, L. M. (1985). Benzene exposure in the United States 1978-1983: An overview. Am. J. Ind. Med. 7, 385-393.
25. 3H]benzene by F-344/N rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 94, 128-140.
26. Sabourin, P. J., Bechtold, W. E., and Henderson, R. F. (1988b). A high pressure liquid chromatographic method for the separation and quantitation of water-soluble radiolabeled benzene metabolites. Anal. Biochem. 170, 316-327.
27. 1 mice. Toxicol. Appl. Pharmacol. 99, 421-444.
28. Selling, L. (1916). Benzol as a leucotoxin. Studies on the degeneration and reseneration of the blood and hematopoietic organs. John Hopkins Hosp. Rep. 17, 83-142.
29. Snyder, R., and Kalf, G. F. (1994). A perspective on benzene leukemogenesis. Crit. Rev. Toxicol. 24, 177-209.
30. Snyder, R., and Kocsis, J. J. (1975). Current concepts of chronic benzene toxicity. Crit. Rev. Toxicol. 3, 265-288.
31. Snyder, R., and Hedli, C. C. (1996). An overview of benzene metabolism. Environ. Health Perspect. 104(Suppl. 6), 1165-1171.
32. Valentine, J. L., Lee, S. S.-T., Seaton, M. J., Asgharian, B., Farris, G., Corton, J. C., Gonzalez, F. J., and Medinsky, M. A (1996). Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 141, 205-213.
33. Wallace, L. A., Pellizzari, E. D., Harwell, T., Perritt, K., and Ziegenfus, R. (1987). Exposures to benzene and other volatile organic compounds from active and passive smoking. Arch. Environ. Health 42, 272-279.
34. Wallace, L. A. (1989). The exposure of the general population to benzene. Cell Biol. Toxicol. 5, 297-314.
35. Wallace, L. A., Pellizzari, E. D., Hartwell, T. D., Davis, V., Michael, L. C., and Whitmore, R. W. (1989). The influence of personal activities on exposure to volatile organic compounds. Environ. Res. 50, 37-55.
36. Wallace, L. (1996). Environmental Exposure to benzene: An update. Environ. Health Perspect. 104(Suppl. 6), 1129-1136.