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Volumn 104, Issue SUPPL. 6, 1996, Pages 1211-1218

Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity

Author keywords

Benzene; Benzoquinone; Cytochrome P4502E1; Humans; Hydroquinone; Lipid peroxidation; OH radicals; Rats; Semiquinone

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BENZENE; BENZOQUINONE; CATECHOL; CYTOCHROME P450; EDETIC ACID; HYDROQUINONE; HYDROXYL RADICAL; IRON; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHENOBARBITAL; PHENOL; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

EID: 0030462518     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.961041211     Document Type: Conference Paper
Times cited : (67)

References (35)
  • 1
    • 0028284416 scopus 로고
    • Cytochrome P450 destruction and radical scavenging by benzene and its metabolites: Evidence for the key role or quinones
    • Soucek P, Filipcova B, Gut I. Cytochrome P450 destruction and radical scavenging by benzene and its metabolites: evidence for the key role or quinones. Biochem Pharmacol 47:2233-2242 (1994).
    • (1994) Biochem Pharmacol , vol.47 , pp. 2233-2242
    • Soucek, P.1    Filipcova, B.2    Gut, I.3
  • 3
    • 0344935357 scopus 로고
    • Influence of frequently used industrial solvents and monomers of plastics on xenobiotic metabolism
    • Gut I. Influence of frequently used industrial solvents and monomers of plastics on xenobiotic metabolism. Zbl Pharmacol 122:1139-1161 (1983).
    • (1983) Zbl Pharmacol , vol.122 , pp. 1139-1161
    • Gut, I.1
  • 4
    • 0023900010 scopus 로고
    • Ethanol, fasting and acetone-inducible cytochrome P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies
    • Johansson I, Ekström G, Scholte B, Puzycki D, Jörnvall H, Ingelman-Sundberg M. Ethanol, fasting and acetone-inducible cytochrome P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 27:1925-1934 (1988).
    • (1988) Biochemistry , vol.27 , pp. 1925-1934
    • Johansson, I.1    Ekström, G.2    Scholte, B.3    Puzycki, D.4    Jörnvall, H.5    Ingelman-Sundberg, M.6
  • 5
    • 0024386439 scopus 로고
    • Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 in rat liver and lung
    • Tindberg N, Ingelman-Sundberg M. Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 in rat liver and lung. Biochemistry 28:4449-4504 (1989).
    • (1989) Biochemistry , vol.28 , pp. 4449-4504
    • Tindberg, N.1    Ingelman-Sundberg, M.2
  • 6
    • 0024563581 scopus 로고
    • Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase
    • Koop DR, Laethem AL, Schnier GG, Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase. Toxicol Appl Pharmacol 98:278-288 (1989).
    • (1989) Toxicol Appl Pharmacol , vol.98 , pp. 278-288
    • Koop, D.R.1    Laethem, A.L.2    Schnier, G.G.3
  • 7
    • 0024466836 scopus 로고
    • Imunochemical characterization of cytochrome P450 responsible for benzene oxidation in rat liver
    • Nakajima T, Elovaara E, Park SS, Gelboin HV, Hietanen E, Vainio H. Imunochemical characterization of cytochrome P450 responsible for benzene oxidation in rat liver. Carcinogenesis 10:1713-1717 (1989).
    • (1989) Carcinogenesis , vol.10 , pp. 1713-1717
    • Nakajima, T.1    Elovaara, E.2    Park, S.S.3    Gelboin, H.V.4    Hietanen, E.5    Vainio, H.6
  • 8
    • 0026553033 scopus 로고
    • Influence of P-450 2E1 induction on benzene metabolism in rat hepatocytes and on biliary excretion
    • Schrenk D, Ingelman-Sundberg M, Bock KW. Influence of P-450 2E1 induction on benzene metabolism in rat hepatocytes and on biliary excretion. Drug Metabol Disp 20:137-141 (1992).
    • (1992) Drug Metabol Disp , vol.20 , pp. 137-141
    • Schrenk, D.1    Ingelman-Sundberg, M.2    Bock, K.W.3
  • 9
    • 0027717580 scopus 로고
    • Benzene and phenol metabolism by mouse and rat liver microsomes
    • Schlosser PM, Bond JM, Medinsky MA. Benzene and phenol metabolism by mouse and rat liver microsomes. Carcinogenesis 14(12):2477-2486 (1993).
    • (1993) Carcinogenesis , vol.14 , Issue.12 , pp. 2477-2486
    • Schlosser, P.M.1    Bond, J.M.2    Medinsky, M.A.3
  • 10
  • 11
    • 0028142345 scopus 로고
    • Benzene metabolism by human liver microsomes in relation to cytochrome P4502E1 activity
    • Seaton MJ, Schlosser PM, Bond JA, Medinsky MA. Benzene metabolism by human liver microsomes in relation to cytochrome P4502E1 activity. Carcinogenesis 14:1799-1806 (1994).
    • (1994) Carcinogenesis , vol.14 , pp. 1799-1806
    • Seaton, M.J.1    Schlosser, P.M.2    Bond, J.A.3    Medinsky, M.A.4
  • 12
    • 0021133491 scopus 로고
    • DT-diaphorase and peroxidase influence the covalent binding of phenol, the major metabolite of benzene
    • Smart RC, Zannoni VG. DT-diaphorase and peroxidase influence the covalent binding of phenol, the major metabolite of benzene. Molec Pharmacol 26:105-111 (1984).
    • (1984) Molec Pharmacol , vol.26 , pp. 105-111
    • Smart, R.C.1    Zannoni, V.G.2
  • 13
    • 0024512180 scopus 로고
    • Effect of dimethyl sulfoxide on the genotoxicity and metabolism of benzene in vivo
    • Anwar WA, Au WW, Legator MS, Ramanujam VMS. Effect of dimethyl sulfoxide on the genotoxicity and metabolism of benzene in vivo. Carcinogenesis 10:441-445 (1989).
    • (1989) Carcinogenesis , vol.10 , pp. 441-445
    • Anwar, W.A.1    Au, W.W.2    Legator, M.S.3    Ramanujam, V.M.S.4
  • 14
    • 0023840631 scopus 로고
    • Cytochrome P-450 mediated oxidation of substrates by electron-transfer:role of oxygen radicals and of 1-and 2-electron oxidation of paracetamol
    • Van der Straat R, Vromans RM, Bosman P, De Vries J, Vermulen NPE. Cytochrome P-450 mediated oxidation of substrates by electron-transfer:role of oxygen radicals and of 1-and 2-electron oxidation of paracetamol. Chem Biol Interact 64:267-280 (1988).
    • (1988) Chem Biol Interact , vol.64 , pp. 267-280
    • Van Der Straat, R.1    Vromans, R.M.2    Bosman, P.3    De Vries, J.4    Vermulen, N.P.E.5
  • 15
    • 0022323885 scopus 로고
    • Quinones and toxic metabolites of benzene
    • Irons RD. Quinones and toxic metabolites of benzene. J Toxicol Environ Health 16:673-678 (1985).
    • (1985) J Toxicol Environ Health , vol.16 , pp. 673-678
    • Irons, R.D.1
  • 16
    • 0025328833 scopus 로고
    • Cigarette smoke-induced DNA damage: Role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine
    • Leanderson P, Tagesson CH. Cigarette smoke-induced DNA damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine. Chem Biol Interact 75:71-81 (1990).
    • (1990) Chem Biol Interact , vol.75 , pp. 71-81
    • Leanderson, P.1    Tagesson, C.H.2
  • 17
    • 0041301865 scopus 로고
    • Metabolism of reactive oxygen species
    • Tichavská B, Gut I. Metabolism of reactive oxygen species [in Czech]. Chem Listy 88:580-590 (1994).
    • (1994) Chem Listy , vol.88 , pp. 580-590
    • Tichavská, B.1    Gut, I.2
  • 19
    • 0021833801 scopus 로고
    • Characterization of enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P450 heme
    • Schaefer WH, Harris TM, Gungerich FP. Characterization of enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P450 heme. Biochemistry 24:3254-3263 (1985).
    • (1985) Biochemistry , vol.24 , pp. 3254-3263
    • Schaefer, W.H.1    Harris, T.M.2    Gungerich, F.P.3
  • 20
    • 0017764686 scopus 로고
    • Metabolism of vinyl chloride:destruction of the heme of highly purified liver microsomal cytochrome P-450 by a metabolite
    • Guengerich FP, Strickland TW. Metabolism of vinyl chloride:destruction of the heme of highly purified liver microsomal cytochrome P-450 by a metabolite. Mol Pharmacol 13:993-1004 (1977).
    • (1977) Mol Pharmacol , vol.13 , pp. 993-1004
    • Guengerich, F.P.1    Strickland, T.W.2
  • 21
    • 0024386439 scopus 로고
    • Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 in rat liver and lung
    • Tindberg N, Ingelman-Sundberg M. Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 in rat liver and lung. Biochemistry 28:4499-4504 (1989).
    • (1989) Biochemistry , vol.28 , pp. 4499-4504
    • Tindberg, N.1    Ingelman-Sundberg, M.2
  • 22
    • 0016174577 scopus 로고
    • Preparation and properties of partially purified cytochrome P450 and reduced NADPH-cytochrome P450 reductase from rabbit liver microsomes
    • Van der Hoeven TA, Coon MJ, Preparation and properties of partially purified cytochrome P450 and reduced NADPH-cytochrome P450 reductase from rabbit liver microsomes. J Biol Chem 249:6302-6310 (1974).
    • (1974) J Biol Chem , vol.249 , pp. 6302-6310
    • Van Der Hoeven, T.A.1    Coon, M.J.2
  • 25
    • 0019853192 scopus 로고
    • Inhibition of lymphocyte transformation and microtubule assembly by quinone metabolites of benzene: Evidence for a common mechanism
    • Irons RD, Neptun DA, Pfeifer RW. Inhibition of lymphocyte transformation and microtubule assembly by quinone metabolites of benzene: evidence for a common mechanism. J Reticuloendothelial Soc 30:359-371 (1981).
    • (1981) J Reticuloendothelial Soc , vol.30 , pp. 359-371
    • Irons, R.D.1    Neptun, D.A.2    Pfeifer, R.W.3
  • 26
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes: Evidence for its hemoprotein nature
    • Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes: evidence for its hemoprotein nature. J Biol Chem 239:2370-2378 (1964).
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 29
    • 0022763647 scopus 로고
    • A simple assay of the superoxide generation with Tiron as an EPR-visible radical scavenger
    • Ledenev AN, Konstantinov AA, Popova E, Ruuge EK. A simple assay of the superoxide generation with Tiron as an EPR-visible radical scavenger. Biochem Internatl 13:391-396 (1986).
    • (1986) Biochem Internatl , vol.13 , pp. 391-396
    • Ledenev, A.N.1    Konstantinov, A.A.2    Popova, E.3    Ruuge, E.K.4
  • 30
  • 31
    • 0026070497 scopus 로고
    • A mini review: Fundamental aspects of spin trapping with DMPO
    • Makino K, Hagiwara T, Murakami A. A mini review: fundamental aspects of spin trapping with DMPO. Radiat Phys Chem 37:(5-6) 657-665 (1991).
    • (1991) Radiat Phys Chem , vol.37 , Issue.5-6 , pp. 657-665
    • Makino, K.1    Hagiwara, T.2    Murakami, A.3
  • 32
    • 0019776866 scopus 로고
    • Production of formaldehyde during metabolism of dimethylsulfoxide by hydroxyl radical generating systems
    • Klein SM, Cohen G, Cederbaum AI. Production of formaldehyde during metabolism of dimethylsulfoxide by hydroxyl radical generating systems. Biochemistry 20:6006-6012 (1981).
    • (1981) Biochemistry , vol.20 , pp. 6006-6012
    • Klein, S.M.1    Cohen, G.2    Cederbaum, A.I.3
  • 33
    • 0025305462 scopus 로고
    • Generation of hydroxyl radicals during benzene toxicity
    • Khan S, Krishnamurthy R, Padnya KP. Generation of hydroxyl radicals during benzene toxicity. Biochem Pharmacol 39:1393-1395 (1990).
    • (1990) Biochem Pharmacol , vol.39 , pp. 1393-1395
    • Khan, S.1    Krishnamurthy, R.2    Padnya, K.P.3
  • 34
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Fleischer S, Packer L, eds. New York:Academic Press
    • Buege JA, Aust SD. Microsomal lipid peroxidation. In: Methods in Enzymology, Vol 52 (Fleischer S, Packer L, eds). New York:Academic Press, 1978;302-310.
    • (1978) Methods in Enzymology , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 35
    • 0028288452 scopus 로고
    • Prooxidant and antioxidant properties of iron-hydroquinone and iron-1,2,4-benzene triol complex. Implications for benzene toxicity
    • Singh V, Ahmad S, Rao GS. Prooxidant and antioxidant properties of iron-hydroquinone and iron-1,2,4-benzene triol complex. Implications for benzene toxicity. Toxicology 89:25-33 (1994).
    • (1994) Toxicology , vol.89 , pp. 25-33
    • Singh, V.1    Ahmad, S.2    Rao, G.S.3


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