In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat

Toxicological Sciences

Volumn 62, Issue 1, 2001, Pages 46-53

  Lewis, Bernadette C ^a   Hudgins, Shawnte ^a   Lewis, Albert ^a   Schorr, Kristel ^a   Sommer, Rebecca ^c,d   Peterson, Richard E ^c   Flaws, Jodi A ^b   Furth, Priscilla A ^a,b  

^a INSTITUTE OF HUMAN VIROLOGY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d BATES COLLEGE   (United States)

Author keywords

Differentiation; Estrogen receptor ; In utero and lactational exposure; Mammary gland; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DRUG VEHICLE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; PLACEBO; PROGESTERONE RECEPTOR;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST DUCT; CELL DIFFERENTIATION; CONTROLLED STUDY; EUTHANASIA; FEMALE; GESTATIONAL AGE; HISTOPATHOLOGY; HORMONE RESPONSE; LACTATION; MAMMARY GLAND; NONHUMAN; OVARIECTOMY; PERINATAL PERIOD; PRENATAL EXPOSURE; PROGENY; PROTEIN EXPRESSION; RAT; STIMULATION; WEANING;

ACTINS; ANIMALS; ANIMALS, NEWBORN; BREAST; CELL DIFFERENTIATION; DNA PRIMERS; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; LACTATION; OVARIECTOMY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

ANIMALIA;

EID: 0034963327     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.1.46     Document Type: Article

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