Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways

Cell Growth and Differentiation

Volumn 7, Issue 1, 1996, Pages 13-20

  Li, Minglin ^a   Hu, Jiadi ^a   Heermeier, Kathrin ^b   Hennighausen, Lothar ^b   Furth, Priscilla A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST BIOPSY; BREAST TUMOR; CELL DEATH; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; INVOLUTION; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; APOPTOSIS; BASE SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, NORTHERN; CASEINS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION, VIRAL; IN SITU HYBRIDIZATION; LACTALBUMIN; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MILK PROTEINS; POLYMERASE CHAIN REACTION; PREGNANCY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 0030054222     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Strange, R., Li, F., Saurer, S., Burkhardt, A., and Friis, R. Apoptotic cell death and tissue remodeling during mouse mammary gland involution. Development (Camb.), 115: 49-58, 1992.
2. Sedlak, T. W., Zoltan, N. O., Yang, E., Wang, K., Boise, L H., Thompson, C. B., and Korsmeyer, S J. Multiple Bcl-2 family members demonstrate selective dimerization with Bax. Proc. Natl. Acad. Sci. USA, 92: 7834-7838, 1995.
3. Oltvai, Z. N., and Korsmeyer, S. J Checkpoints of dueling dimers foil death wishes. Cell, 79: 189-192, 1994.
4. Li, M., Hu, J., Heermeier, K., Hennighausen, L., and Furth, P. A. Expression of a viral oncoprotein during mammary gland development alters cell fate and function, induction of p53-independent apoptosis is followed by impaired milk protein production in surviving cells. Cell Growth & Differ., 7: 3-11, 1996
5. Miyashita, T. and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995
6. Li, B., Greenberg, N., Stephens, L. C., Meyn, R., Medina, D , and Rosen, J M. Preferential overexpression of a 172 Arg-Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth & Differ., 5: 711-721, 1994.
7. Merlo, G. R., Basolo, F., Fiore, L., Duboc, L., and Hynes, N. E. p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin. J. Cell Biol., 128: 1185-1196, 1995.
8. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C A., Jr., Butel, J. S., and Bradley, A Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (Lond.), 356: 215-221, 1992
9. Tzeng, Y-J., Guhl, E., Graessmann, M., and Graessmann, A. Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene. Oncogene, 8: 1965-1971, 1993.
10. Boise, L. H., Gonzalez-Garcia, M., Postema, C E , Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. A. bcl-X, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
11. L is the major bcl-X mRNA form expressed during murine development and its product localizes to mitochondria. Development (Camb), 120: 3033-3042, 1994.
12. Oltvai, Z. N., Milliman, L. L., and Korsmeyer, S. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
13. Armstrong, J. F., Kaufman, M. H., Harrison, D. J., and Clarke, A. R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol., 5: 931-936, 1995.
14. Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y-P., Pinkel, D., Gray, J., Bradley, A., Medina, D., and Varmus, H. E. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & Dev., 9: 882-895, 1995.
15. Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T., and Van Dyke, T. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell, 78: 703-711, 1994.
16. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79: 329-339, 1994.
17. Dickson, S. R., and Warburton, M. J. Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland. J. Histochem. Cytochem , 40: 897-703, 1992.
18. Guenette, R. S., Corbeil, H. B., Léger, J., Wong, K., Mézl, V., Mooibroek, M., and Tenniswood, M. Induction of gene expression during involution of the lactating mammary gland of the rat. J. Mol. Endocrinol., 12: 47-60, 1994.
19. Lefebvre, O., Wolf, C., Limacher, J. M., Hutin, P., Wendling, C., LeMeur, M., Basset, P., and Rio, M. C. The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis. J. Cell Biol., 119: 997-1002, 1992.
20. Marti, A., Jehn, B., Costello, E., Keon, N., Ke, G., Martin, F., and Jaggi, R. Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells. Oncogene, 9: 1213-1223, 1994.
21. Boudreau, N., Sympson, C. J., Werb, Z., and Bissell, M. J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix Science (Washington DC), 267: 891-893, 1995.
22. Lin, C. Q., and Bissell, M. J. Multi-faceted regulation of cell differentiation by extracellular matrix. FASEB J., 7: 737-743, 1993.
23. Furth, P. A , St. Onge, L., Boger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H., and Heninghausen, L. Temporal control of gene expression in transgenic mice by a tetracycline responsive promoter. Proc. Acad. Natl. Sci. USA, 91: 9302-9306, 1994.
24. Hennighausen, L., Wall, R., Tillmann, U., Li, M., and Furth, P. A. Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system. J Cell Biochem., in press, 59: 463-472, 1995.
25. Chomczynski, P., and Sacchi, N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
26. Hennighausen, L G., and Sippel, A. E. The mouse whey acidic protein is a novel member of the family of "four-disulfide core" proteins. Nucleic Acids Res., 10: 2677-2684, 1982.
27. Hennighausen, L. G., and Sippel, A. E. Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. Eur. J. Biochem., 125: 131-141, 1982.
28. Robinson, G. W., McKnight, R. A., Smith, G. H., and Hennighausen, L Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development (Camb.), 121: 2079-2090, 1995.