4-(Methylnitrosamino) 1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages

Cancer Immunology, Immunotherapy

Volumn 49, Issue 11, 2000, Pages 663-670

  Rioux, N ^a   Castonguay, A ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Cytokines; Macrophages; Nitrosamine; Tobacco

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; CARCINOGEN; COLONY STIMULATING FACTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; NICOTINE DERIVATIVE; TUMOR NECROSIS FACTOR; ALKYLATING AGENT; CARBON; CYTOKINE; IMMUNOGLOBULIN M; IMMUNOMODULATING AGENT; MACROPHAGE CHEMOTACTIC FACTOR; NITROSAMINE; TOBACCO SMOKE;

ALKYLATION; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; LEUKEMIA CELL LINE; LUNG CARCINOGENESIS; LUNG CARCINOMA; MACROPHAGE; NATURAL KILLER CELL; OXIDATION; PRIORITY JOURNAL; TOBACCO; CARCINOGENICITY; CELL ACTIVITY; DETOXIFICATION; IMMUNE SYSTEM; LUNG CANCER; METHYLATION; MOUSE; NONHUMAN; SECRETORY CELL; SMOKING;

ALKYLATION; CARCINOGENS; CHEMOKINE CCL2; CYTOKINES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-6; LUNG; LUNG NEOPLASMS; LYMPHOMA; MACROPHAGES; MOLECULAR STRUCTURE; NITROSAMINES; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 0034954740     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620000157     Document Type: Article

References (42)

1. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages
2. NF-κB: Ten years after
3. Function and activation of NF-κB in the immune system
4. CC chemokines in allergic inflammation
5. Immunotoxicology of cigarette smoke condensates: Suppression of macrophages responsiveness to interferon gamma
6. Formation and analysis of tobacco-specific N-nitrosamines
7. Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage
8. Tumor-induced immune dysfunction: The macrophage connection
9. CSF-I regulation of IL-6 gene expression by murine macrophages: A pivotal role for GM-CSF
10. The biology of human granulocyte-macrophage colony-stimulating factor (GM-CSF)
11. The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukine-2 production, but not CD25, ICAM-1, or LFA-1 expression
12. Recent advances in the understanding of interleukin-2 signal transduction
13. Inhibition of natural killer cell activity in mice treated with tobacco specific carcinogen NNK
14. Activation of HIV gene expression during monocyte differentiation by induction of NF-kappaB
15. Biochemistry, biology, and carcinogencity of tobacco-specific N-nitrosamines
16. Metabolism in the F344 rat of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen
17. Effect of chronic tobacco smoke exposure on the function of alveolar macrophages in mice
18. Biological and clinical aspects of interleukin 6
19. The biological significance of tobacco-specific N-nitrosamines: Smoking and adenocarcinoma of the lung
20. Immune and inflammatory function in cigarette smokers
21. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB. Requirement of ras/mitogen-activated protein kinases in the activation of nf-kappaB by oxidants
22. Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes
23. Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone and benzo[a]pyrene
24. Recombinant human granulocyte-macrophage colony-stimulating factor triggers interleukin-10 expression in the monocytic cell line U937
25. Transcriptional changes in macrophage TNF-alpha expression following dimethylnitrosamine exposure in vivo
26. Effect of in vivo administration of the carcinogen benzo(a)pyrene on interleukine-2 and interleukine-3 production
27. Interleukin-10
28. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by IL-I, TNF, glucocorticoids and 17-est-radiol
29. Investigation of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
30. Recovery from 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induce immunosuppression in A/J mice by treatment with nonsteroidal anti-inflammatory drugs
31. Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398
32. Inhibitors of lipoxygenase: A new class of cancer chemopreventive agents
33. The induction of cyclooxygenase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-κB
34. Dimethylnitrosamine(DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression
35. In vitro effects of srnokeless tobacco extract on tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1 beta) production, and on lymphocyte proliferation
36. Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes
37. Biotransformation of the tobacco-specifc carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells
38. Immunomodulatory effects of cigarette smoke
39. Establishment and characterization of a human histiocytic lymphoma cell line (U937)
40. The pathophysiology of tumor necrosis factors
41. Tobacco smoke induces coordinate activation of HSF and inhibition of NFkappaB in human monocytes: Effects on TNFalpha release
42. Interleukin (IL)-10 inhibits nuclear factor κB (NF-κB) activation in human monocytes