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Volumn 26, Issue 2, 1996, Pages 199-211

The biological significance of tobacco-specific N-nitrosamines: Smoking and adenocarcinoma of the lung

Author keywords

(NNK); 4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone; K ras oncogene activation; Lung adenocarcinoma (AC); Metabolic activation; SCC; Squamous cell carcinoma; Tobacco specific N nitrosamines (TSNA)

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; NITROSAMINE;

EID: 0029880858     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.3109/10408449609017931     Document Type: Review
Times cited : (112)

References (76)
  • 1
    • 0025752352 scopus 로고
    • Tobacco-specific nitrosamines. Round table discussion
    • 15th International Cancer Congress, August 1990, Hamburg, Germany
    • Hoffmann, D. and Spiegelhalder, B., Eds., Tobacco-specific nitrosamines. Round table discussion, 15th International Cancer Congress, August 1990, Hamburg, Germany, Crit. Rev. Toxicol., 21, 235, 1991.
    • (1991) Crit. Rev. Toxicol. , vol.21 , pp. 235
    • Hoffmann, D.1    Spiegelhalder, B.2
  • 2
    • 0000359188 scopus 로고
    • Tobacco Habits Other than Smoking; Betel Quid and Areca-Nut Chewing; and some Related Nitrosamines
    • Lyon
    • International Agency for Research on Cancer, Tobacco Habits Other than Smoking; Betel Quid and Areca-Nut Chewing; and some Related Nitrosamines, IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Lyon, 37, 1985.
    • (1985) IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans , pp. 37
  • 9
    • 76549257892 scopus 로고
    • Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma
    • Wynder, E. L. and Graham, E. G., Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma, J. Am. Med. Assoc., 143, 329, 1950.
    • (1950) J. Am. Med. Assoc. , vol.143 , pp. 329
    • Wynder, E.L.1    Graham, E.G.2
  • 10
    • 0017720466 scopus 로고
    • Comparative epidemiology of tobacco-related cancers
    • Wynder, E. L. and Stellman, S. D., Comparative epidemiology of tobacco-related cancers, Cancer Res., 37, 4608, 1977.
    • (1977) Cancer Res. , vol.37 , pp. 4608
    • Wynder, E.L.1    Stellman, S.D.2
  • 11
    • 0023423915 scopus 로고
    • Epidemiologic patterns in lung cancer by histologic type
    • Wynder, E. L. and Covey, L. S., Epidemiologic patterns in lung cancer by histologic type, Eur. J. Cancer Clin. Oncol., 23, 1491, 1987.
    • (1987) Eur. J. Cancer Clin. Oncol. , vol.23 , pp. 1491
    • Wynder, E.L.1    Covey, L.S.2
  • 12
    • 0025280507 scopus 로고
    • Significant changes in the distribution of histologic type of lung cancer. A review of 4,928 cases
    • El-Torky, M., El-Zeky, F., and Hall, J. C., Significant changes in the distribution of histologic type of lung cancer. A review of 4,928 cases, Cancer, 65, 1647, 1990.
    • (1990) Cancer , vol.65 , pp. 1647
    • El-Torky, M.1    El-Zeky, F.2    Hall, J.C.3
  • 14
    • 0018669681 scopus 로고
    • Adenocarcinoma of the lung: Recent results from the Veterans Administration lung group
    • Cox, J. D. and Yesner, R. A., Adenocarcinoma of the lung: recent results from the Veterans Administration lung group, Am. Rev. Respir. Dis., 120, 1025, 1979.
    • (1979) Am. Rev. Respir. Dis. , vol.120 , pp. 1025
    • Cox, J.D.1    Yesner, R.A.2
  • 15
    • 0023875438 scopus 로고
    • Histologic and cytologic patterns of lung cancer in 2,580 men and women over a 15-year period
    • Johnston, W. W., Histologic and cytologic patterns of lung cancer in 2,580 men and women over a 15-year period, Acta. Cytol., 32, 163, 1988.
    • (1988) Acta. Cytol. , vol.32 , pp. 163
    • Johnston, W.W.1
  • 17
    • 0019792705 scopus 로고
    • Cancer incidence and mortality in the United States, 1973-1977
    • Young, J. L., Percy, C. L., and Asire, A. J., Eds., Cancer incidence and mortality in the United States, 1973-1977, J. Natl. Cancer Inst. Monogr., 57, 1, 1981.
    • (1981) J. Natl. Cancer Inst. Monogr. , vol.57 , pp. 1
    • Young, J.L.1    Percy, C.L.2    Asire, A.J.3
  • 18
    • 0021993858 scopus 로고
    • Bronchiogenic carcinoma in Olmsted County, 1935-1979
    • Beard, M. C., Annegers, J. F., Woolner, L. B., and Kurland, L. T., Bronchiogenic carcinoma in Olmsted County, 1935-1979, Cancer, 55, 2026, 1985.
    • (1985) Cancer , vol.55 , pp. 2026
    • Beard, M.C.1    Annegers, J.F.2    Woolner, L.B.3    Kurland, L.T.4
  • 20
    • 0025851284 scopus 로고
    • Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?
    • Shopland, D. R., Eyre, H.-J., and Pechacek, T., Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?, J. Natl. Cancer Inst., 83, 1142, 1991.
    • (1991) J. Natl. Cancer Inst. , vol.83 , pp. 1142
    • Shopland, D.R.1    Eyre, H.-J.2    Pechacek, T.3
  • 21
    • 0029042955 scopus 로고
    • Changes in cigarette design and composition over time and how they influence the yields of smoke constituents
    • Hoffmann, D., Djordjevic, M. V., and Brunnemann, K. D., Changes in cigarette design and composition over time and how they influence the yields of smoke constituents, J. Smoking Relat. Disord., 6, 9, 1995.
    • (1995) J. Smoking Relat. Disord. , vol.6 , pp. 9
    • Hoffmann, D.1    Djordjevic, M.V.2    Brunnemann, K.D.3
  • 22
    • 0000744925 scopus 로고
    • Nature of cigarette smoke. Technique of experimental smoking
    • Bradford, J. A., Harlan, W. R., and Hanmer, H. R., Nature of cigarette smoke. Technique of experimental smoking, Ind. Eng. Chem., 28, 836, 1936.
    • (1936) Ind. Eng. Chem. , vol.28 , pp. 836
    • Bradford, J.A.1    Harlan, W.R.2    Hanmer, H.R.3
  • 25
    • 0006737257 scopus 로고
    • The case for mediumnicotine, low-tar, low-carbon monoxide cigarettes
    • Russell, M. A. H., The case for mediumnicotine, low-tar, low-carbon monoxide cigarettes, Banbury Rep., 3, 297, 1980.
    • (1980) Banbury Rep. , vol.3 , pp. 297
    • Russell, M.A.H.1
  • 27
    • 0019980237 scopus 로고
    • Estimating the yield to smokers of tar, nicotine, and carbon monoxide from the "lowest yield" ventilated filter-cigarettes
    • Kozlowski, L. T., Rickert, W. S., Pope, M. A., Robinson, J. C., and Frecker, R. C., Estimating the yield to smokers of tar, nicotine, and carbon monoxide from the "lowest yield" ventilated filter-cigarettes, Br. J. Addict., 77, 159, 1982.
    • (1982) Br. J. Addict. , vol.77 , pp. 159
    • Kozlowski, L.T.1    Rickert, W.S.2    Pope, M.A.3    Robinson, J.C.4    Frecker, R.C.5
  • 28
    • 0020052250 scopus 로고
    • Effects of a nicotine enriched cigarette on nicotine titration, daily cigarette consumption and levels of carbon monoxide, cotinine and nicotine
    • Fagerström, K. O., Effects of a nicotine enriched cigarette on nicotine titration, daily cigarette consumption and levels of carbon monoxide, cotinine and nicotine, Psychopharmacology, 77, 164, 1982.
    • (1982) Psychopharmacology , vol.77 , pp. 164
    • Fagerström, K.O.1
  • 29
    • 0022385424 scopus 로고
    • Cigarette smoking as a risk factor for cardiovascular disease. VI. Compensation with nicotine availability as a single variable
    • Haley, N. J., Sepkovic, D. W., Hoffmann, D., and Wynder, E. L., Cigarette smoking as a risk factor for cardiovascular disease. VI. Compensation with nicotine availability as a single variable, Clin. Pharmacol. Ther., 38, 164, 1985.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 164
    • Haley, N.J.1    Sepkovic, D.W.2    Hoffmann, D.3    Wynder, E.L.4
  • 30
    • 0023493466 scopus 로고
    • Microcomputer-aided measurements of puff parameters during smoking of low- and medium-tar cigarettes
    • Puustinen, P., Olkkonen, H., Kolonen, S., and Tuomisto, J., Microcomputer-aided measurements of puff parameters during smoking of low- and medium-tar cigarettes, Scand. J. Clin. Lab. Invest., 47, 655, 1987.
    • (1987) Scand. J. Clin. Lab. Invest. , vol.47 , pp. 655
    • Puustinen, P.1    Olkkonen, H.2    Kolonen, S.3    Tuomisto, J.4
  • 31
    • 0024347531 scopus 로고
    • Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke: A contribution to relative risk evaluation
    • Fischer, S., Spiegelhalder, B., and Preussmann, R., Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke: a contribution to relative risk evaluation, Carcinogenesis, 10, 1059, 1989.
    • (1989) Carcinogenesis , vol.10 , pp. 1059
    • Fischer, S.1    Spiegelhalder, B.2    Preussmann, R.3
  • 32
    • 9244250713 scopus 로고
    • Tobacco-specific nitrosamine delivery in the mainstream smoke of high- and low-yield cigarettes smoked with varying puff volumes
    • Kallithea, Greece
    • Djordjevic, M. V., Sigountos, C. W., Brunnemann, K. D., and Hoffmann, D., Tobacco-specific nitrosamine delivery in the mainstream smoke of high- and low-yield cigarettes smoked with varying puff volumes, Abstr. CORESTA Symp., Kallithea, Greece, 1990, 54.
    • (1990) Abstr. CORESTA Symp. , pp. 54
    • Djordjevic, M.V.1    Sigountos, C.W.2    Brunnemann, K.D.3    Hoffmann, D.4
  • 34
    • 0025731051 scopus 로고
    • Carcinogenicity of tobacco-specific N-nitrosoamines (TSNA): The role of the vascular network in the selection of target organs
    • Rivenson, A., Hecht, S. S., and Hoffmann, D., Carcinogenicity of tobacco-specific N-nitrosoamines (TSNA): the role of the vascular network in the selection of target organs. Crit. Rev. Toxicol., 21, 255, 1991.
    • (1991) Crit. Rev. Toxicol. , vol.21 , pp. 255
    • Rivenson, A.1    Hecht, S.S.2    Hoffmann, D.3
  • 35
    • 0028177696 scopus 로고
    • Tobacco-specific N-nitrosamines and areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans
    • Hoffmann, D., Brunnemann, K. D., Prokopczyk, B., and Djordjevic, M. V., Tobacco-specific N-nitrosamines and areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans, J. Toxicol. Environ. Health, 41, 1, 1994.
    • (1994) J. Toxicol. Environ. Health , vol.41 , pp. 1
    • Hoffmann, D.1    Brunnemann, K.D.2    Prokopczyk, B.3    Djordjevic, M.V.4
  • 36
    • 0023639749 scopus 로고
    • Tumorigenic activity of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and N′-nitrosonornicotine (NNN) on topical application to Sencar mice
    • LaVoie, E. J., Prokopczyk, B., Rigotty, J., Czech, A., Rivenson, A., and Adams, J. D., Tumorigenic activity of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and N′-nitrosonornicotine (NNN) on topical application to Sencar mice, Cancer Lett., 37, 277, 1987.
    • (1987) Cancer Lett. , vol.37 , pp. 277
    • LaVoie, E.J.1    Prokopczyk, B.2    Rigotty, J.3    Czech, A.4    Rivenson, A.5    Adams, J.D.6
  • 37
    • 0024350057 scopus 로고
    • Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet
    • Hecht, S. S., Morse, M. A., Amin, S., Stoner, G. D., Jordan, K. G., Choi, C.-I., and Chung, F.-L., Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet, Carcinogenesis, 10, 1901, 1989.
    • (1989) Carcinogenesis , vol.10 , pp. 1901
    • Hecht, S.S.1    Morse, M.A.2    Amin, S.3    Stoner, G.D.4    Jordan, K.G.5    Choi, C.-I.6    Chung, F.-L.7
  • 38
    • 0027249692 scopus 로고
    • A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumors in A/J mice
    • Hoffmann, D., Djordjevic, M. V., Rivenson, A., Zang, E., Desai, D., and Amin, S., A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumors in A/J mice, Cancer Lett., 71, 25, 1993.
    • (1993) Cancer Lett. , vol.71 , pp. 25
    • Hoffmann, D.1    Djordjevic, M.V.2    Rivenson, A.3    Zang, E.4    Desai, D.5    Amin, S.6
  • 39
    • 0028566646 scopus 로고
    • Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene: A potentially useful model for evaluation of chemopreventive agents
    • Hecht, S. S., Isaacs, S., and Trushin, N., Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene: a potentially useful model for evaluation of chemopreventive agents, Carcinogenesis, 15, 2721, 1994.
    • (1994) Carcinogenesis , vol.15 , pp. 2721
    • Hecht, S.S.1    Isaacs, S.2    Trushin, N.3
  • 40
    • 0025826718 scopus 로고
    • Tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in infant mice
    • Anderson, L. M., Hecht, S. S., Kovatch, R. M., Amin, S., Hoffmann, D., and Rice, J. M., Tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in infant mice, Cancer Lett., 58, 177, 1991.
    • (1991) Cancer Lett. , vol.58 , pp. 177
    • Anderson, L.M.1    Hecht, S.S.2    Kovatch, R.M.3    Amin, S.4    Hoffmann, D.5    Rice, J.M.6
  • 41
    • 0026046328 scopus 로고
    • A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-methylnitrosaminopropionitrile (MNPN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) upon local applications to mouse skin and rat oral mucosa
    • Prokopczyk, G., Rivenson, A., and Hoffmann, D. A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-methylnitrosaminopropionitrile (MNPN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) upon local applications to mouse skin and rat oral mucosa, Cancer Lett., 60, 151, 1991.
    • (1991) Cancer Lett. , vol.60 , pp. 151
    • Prokopczyk, G.1    Rivenson, A.2    Hoffmann, D.3
  • 42
    • 0025803685 scopus 로고
    • Carcinogenesis in rats by substituted dialkylnitrosamines given by gavage
    • Lijinsky, W., Saavedra, J. E., and Kovatch, R. M., Carcinogenesis in rats by substituted dialkylnitrosamines given by gavage, In Vivo, 5, 85, 1991.
    • (1991) In Vivo , vol.5 , pp. 85
    • Lijinsky, W.1    Saavedra, J.E.2    Kovatch, R.M.3
  • 43
    • 0024262907 scopus 로고
    • A study of tobacco carcinogenesis. XLII. Induction of lung and pancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines
    • Rivenson, A., Hoffmann, D., Prokopczyk, B., Amin, S., and Hecht, S. S., A study of tobacco carcinogenesis. XLII. Induction of lung and pancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines, Cancer Res., 48, 6912, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 6912
    • Rivenson, A.1    Hoffmann, D.2    Prokopczyk, B.3    Amin, S.4    Hecht, S.S.5
  • 44
    • 0018889232 scopus 로고
    • Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N′-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
    • Hecht, S. S., Chen, C.-H. B., Ohmori, T., and Hoffmann, D., Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N′-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, Cancer Res., 40, 298, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 298
    • Hecht, S.S.1    Chen, C.-H.B.2    Ohmori, T.3    Hoffmann, D.4
  • 45
    • 0021260334 scopus 로고
    • Dose-response study on the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats
    • Hoffmann, D., Rivenson, A., Amin, S., and Hecht, S. S., Dose-response study on the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats, J. Cancer Res. Clin. Oncol., 108, 81, 1984.
    • (1984) J. Cancer Res. Clin. Oncol. , vol.108 , pp. 81
    • Hoffmann, D.1    Rivenson, A.2    Amin, S.3    Hecht, S.S.4
  • 46
    • 0025297169 scopus 로고
    • 6-methylguanine formation on Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • 6-methylguanine formation on Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, Cancer Res., 50, 3772, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 3772
    • Belinsky, S.A.1    Foley, J.F.2    White, C.M.3    Anderson, M.W.4    Maronpot, R.5
  • 47
    • 0025768503 scopus 로고
    • Local and systemic carcinogenic effects of alkylating carcinogens in rats treated with intravesicular administration
    • Lijinsky, W., Thomas, B. J., and Kovatch, R. M., Local and systemic carcinogenic effects of alkylating carcinogens in rats treated with intravesicular administration, Jpn. J. Cancer Res., 82, 980, 1991.
    • (1991) Jpn. J. Cancer Res. , vol.82 , pp. 980
    • Lijinsky, W.1    Thomas, B.J.2    Kovatch, R.M.3
  • 48
    • 0019428947 scopus 로고
    • Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine in Syrian golden hamsters
    • Hoffmann, D., Castonguay, A., Rivenson, A., and Hecht, S. S., Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine in Syrian golden hamsters, Cancer Res., 41, 2386, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 2386
    • Hoffmann, D.1    Castonguay, A.2    Rivenson, A.3    Hecht, S.S.4
  • 49
    • 0021090996 scopus 로고
    • Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation
    • Hecht, S. S., Adams, J. D., Numoto, S., and Hoffmann, D., Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation, Carcinogenesis, 4, 1287, 1983.
    • (1983) Carcinogenesis , vol.4 , pp. 1287
    • Hecht, S.S.1    Adams, J.D.2    Numoto, S.3    Hoffmann, D.4
  • 50
    • 0025267835 scopus 로고
    • Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia
    • Schuller, H. M., Witschi, H.-P., Nylen, E., Joshi, P. A., Correa, E., and Becker, K. L., Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia, Cancer Res., 50, 1960, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 1960
    • Schuller, H.M.1    Witschi, H.-P.2    Nylen, E.3    Joshi, P.A.4    Correa, E.5    Becker, K.L.6
  • 51
    • 0027178383 scopus 로고
    • K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors
    • Oreffo, V. I. C., Lin, H.-W., Padmanabhan, R., and Witschi, H., K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors, Carcinogenesis, 14, 451, 1993.
    • (1993) Carcinogenesis , vol.14 , pp. 451
    • Oreffo, V.I.C.1    Lin, H.-W.2    Padmanabhan, R.3    Witschi, H.4
  • 52
    • 0025307212 scopus 로고
    • Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice
    • Hecht, S. S., Jordan, K. G., Choi, C.-I., and Trushin, N., Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice, Carcinogenesis, 11, 1017, 1990.
    • (1990) Carcinogenesis , vol.11 , pp. 1017
    • Hecht, S.S.1    Jordan, K.G.2    Choi, C.-I.3    Trushin, N.4
  • 53
    • 0010490441 scopus 로고
    • Induction of pulmonary tumors in mice by nitrosonornicotine, a possible constituent of tobacco smoke
    • Boyland, E., Roe, J. C., and Gorrod, J. W., Induction of pulmonary tumors in mice by nitrosonornicotine, a possible constituent of tobacco smoke, Nature, 202, 1126, 1984.
    • (1984) Nature , vol.202 , pp. 1126
    • Boyland, E.1    Roe, J.C.2    Gorrod, J.W.3
  • 54
    • 0016803076 scopus 로고
    • A study of tobacco Carcinogenesis. XIV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in rats
    • Hoffmann, D., Raineri, R., Hecht, S. S., Maronpot, R., and Wynder, E. L., A study of tobacco Carcinogenesis. XIV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in rats, J. Natl. Cancer Inst., 55, 977, 1975.
    • (1975) J. Natl. Cancer Inst. , vol.55 , pp. 977
    • Hoffmann, D.1    Raineri, R.2    Hecht, S.S.3    Maronpot, R.4    Wynder, E.L.5
  • 55
    • 0021042254 scopus 로고
    • Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N′-nitrosonornicotine and N′-nitrosonornicotine-1-N-oxide
    • Hecht, S. S., Young, R., and Maeura, Y., Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N′-nitrosonornicotine and N′-nitrosonornicotine-1-N-oxide, Cancer Lett., 20, 333, 1983.
    • (1983) Cancer Lett. , vol.20 , pp. 333
    • Hecht, S.S.1    Young, R.2    Maeura, Y.3
  • 56
    • 0017033839 scopus 로고
    • Carcinogenicity of N′-nitrosonornicotine in Sprague-Dawley rats
    • Singer, G. M. and Taylor, H. W., Carcinogenicity of N′-nitrosonornicotine in Sprague-Dawley rats, J. Natl. Cancer Inst., 57, 1275, 1976.
    • (1976) J. Natl. Cancer Inst. , vol.57 , pp. 1275
    • Singer, G.M.1    Taylor, H.W.2
  • 57
    • 0021264515 scopus 로고
    • Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N′-nitrosonornicotine in F344 rats
    • Castonguay, A., Rivenson, A., Trushin, N., Reinhardt, J., Spathopoulos, S., Weiss, C., Reiss, B., and Hecht, S. S., Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N′-nitrosonornicotine in F344 rats, Cancer Res., 44, 2285, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 2285
    • Castonguay, A.1    Rivenson, A.2    Trushin, N.3    Reinhardt, J.4    Spathopoulos, S.5    Weiss, C.6    Reiss, B.7    Hecht, S.S.8
  • 58
    • 0022612312 scopus 로고
    • Influences of ethyl alcohol on the carcinogenic activity of N-nitrosonornicotine
    • Griciute, L., Castegnaro, M., Bereziat, J. C., and Cabrai, J. R., Influences of ethyl alcohol on the carcinogenic activity of N-nitrosonornicotine, Cancer Lett., 31, 267, 1986.
    • (1986) Cancer Lett. , vol.31 , pp. 267
    • Griciute, L.1    Castegnaro, M.2    Bereziat, J.C.3    Cabrai, J.R.4
  • 59
    • 0017326999 scopus 로고
    • A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and ′′-nitrosoanabasine in Syrian golden hamsters
    • Hilfrich, J., Hecht, S. S., and Hoffmann, D., A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and ′′-nitrosoanabasine in Syrian golden hamsters, Cancer Lett., 2, 169, 1977.
    • (1977) Cancer Lett. , vol.2 , pp. 169
    • Hilfrich, J.1    Hecht, S.S.2    Hoffmann, D.3
  • 60
    • 0019479104 scopus 로고
    • Differential effect of chronic ethanol consumption on the carcinogenicity of ′-nitrosopyrrolidine and N′-nitrosonornicotine in male Syrian golden hamsters
    • McCoy, G. D., Hecht, S. S., Katayama, S., and Wynder, E. L., Differential effect of chronic ethanol consumption on the carcinogenicity of ′-nitrosopyrrolidine and N′-nitrosonornicotine in male Syrian golden hamsters, Cancer Res., 41, 2849, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 2849
    • McCoy, G.D.1    Hecht, S.S.2    Katayama, S.3    Wynder, E.L.4
  • 61
    • 0026498408 scopus 로고
    • A study of tobacco carcinogenesis. XLVIII. Carcinogenicity of N′-nitrosonornicotine in mink (Mustela vison)
    • Koppang, N., Rivenson, A., Reith, A., Dahle, H. K., Evensen, O., and Hoffmann, D., A study of tobacco carcinogenesis. XLVIII. Carcinogenicity of N′-nitrosonornicotine in mink (Mustela vison), Carcinogenesis, 13, 1957, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 1957
    • Koppang, N.1    Rivenson, A.2    Reith, A.3    Dahle, H.K.4    Evensen, O.5    Hoffmann, D.6
  • 62
    • 0141520138 scopus 로고
    • The carcinogenicity of nitrosoanabasine, a possible constituent of tobacco smoke
    • Boyland, E., Roe, F. J. C., Gorrod, J. W., and Mitchley, B. C. V., The carcinogenicity of nitrosoanabasine, a possible constituent of tobacco smoke, Br. J. Cancer, 18, 265, 1964.
    • (1964) Br. J. Cancer , vol.18 , pp. 265
    • Boyland, E.1    Roe, F.J.C.2    Gorrod, J.W.3    Mitchley, B.C.V.4
  • 63
    • 0343161301 scopus 로고
    • Isolation, identification, and bioassay of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    • Brunnemann, K. D., Rivenson, A., Czech, A., LaVoie, E. J., and Hoffmann, D., Isolation, identification, and bioassay of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, Proc. Am. Assoc. Cancer Res., 29, 84, 1988.
    • (1988) Proc. Am. Assoc. Cancer Res. , vol.29 , pp. 84
    • Brunnemann, K.D.1    Rivenson, A.2    Czech, A.3    LaVoie, E.J.4    Hoffmann, D.5
  • 64
    • 0024457579 scopus 로고
    • A study of tobacco carcinogenesis. XLIV. Bioassay in A/J mice of some N-nitrosamines
    • Rivenson, A., Djordjevic, M. V., Amin, S., and Hoffmann, D., A study of tobacco carcinogenesis. XLIV. Bioassay in A/J mice of some N-nitrosamines, Cancer Lett., 47, 111, 1989.
    • (1989) Cancer Lett. , vol.47 , pp. 111
    • Rivenson, A.1    Djordjevic, M.V.2    Amin, S.3    Hoffmann, D.4
  • 65
    • 0006429084 scopus 로고
    • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine-derived tobacco-specific nitrosamine, and cancer of the lung and pancreas in humans
    • Brugge, J., Curran, T., Harlow, E., and McCormick, F., Eds., Cold Spring Harbor Laboratories, Cold Spring Harbor, NY
    • Hecht, S. S. and Hoffmann, D., 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine-derived tobacco-specific nitrosamine, and cancer of the lung and pancreas in humans, in Origin of Human Cancer. A. Comprehensive Review, Brugge, J., Curran, T., Harlow, E., and McCormick, F., Eds., Cold Spring Harbor Laboratories, Cold Spring Harbor, NY, 1991, 745.
    • (1991) Origin of Human Cancer. A. Comprehensive Review , pp. 745
    • Hecht, S.S.1    Hoffmann, D.2
  • 66
    • 0024825979 scopus 로고
    • The relevance of tobacco-specific nitrosamines in human cancer
    • Hecht, S. S. and Hoffmann, D., The relevance of tobacco-specific nitrosamines in human cancer, Cancer Surv., 8, 273, 1989.
    • (1989) Cancer Surv. , vol.8 , pp. 273
    • Hecht, S.S.1    Hoffmann, D.2
  • 67
    • 0022654007 scopus 로고
    • A comparative tumorigenicity of DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosomethylamine
    • Hecht, S. S., Trushin, N., Castonguay, A., and Rivenson, A., A comparative tumorigenicity of DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosomethylamine, Cancer Res., 46, 498, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 498
    • Hecht, S.S.1    Trushin, N.2    Castonguay, A.3    Rivenson, A.4
  • 68
    • 0025925258 scopus 로고
    • 6-Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung
    • 6-Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung, Cancer Res., 51, 5551, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 5551
    • Peterson, L.A.1    Hecht, S.S.2
  • 69
    • 0024437222 scopus 로고
    • Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors in A/J mice treated with nitrosamines
    • Belinsky, S. A., Devereaux, T. R., Maronpot, R. R., Stoner, G. D., and Anderson, M. W., Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors in A/J mice treated with nitrosamines, Cancer Res., 49, 5305, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 5305
    • Belinsky, S.A.1    Devereaux, T.R.2    Maronpot, R.R.3    Stoner, G.D.4    Anderson, M.W.5
  • 70
    • 0027319674 scopus 로고
    • 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA
    • 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA, Carcinogenesis, 14, 151, 1993.
    • (1993) Carcinogenesis , vol.14 , pp. 151
    • Mustonen, R.1    Schoket, B.2    Hemminki, K.3
  • 72
    • 0026680448 scopus 로고
    • Clinical significance of ras oncogene activation in human lung cancer
    • Rodenhuis, S. and Slebos, R. J. C., Clinical significance of ras oncogene activation in human lung cancer, Cancer Res. Suppl., 52, 2665s, 1992.
    • (1992) Cancer Res. Suppl. , vol.52
    • Rodenhuis, S.1    Slebos, R.J.C.2
  • 73
    • 0025322751 scopus 로고
    • Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes
    • Kobayashi, T., Tsuda, H., Nognchi, M., Hirohashi, S., Shimosato, Y., Goya, T., and Hayata, Y., Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes, Cancer, 66, 289, 1990.
    • (1990) Cancer , vol.66 , pp. 289
    • Kobayashi, T.1    Tsuda, H.2    Nognchi, M.3    Hirohashi, S.4    Shimosato, Y.5    Goya, T.6    Hayata, Y.7
  • 74
    • 0025965491 scopus 로고
    • Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine
    • Belinsky, S. A., Devereaux, T. R., White, C. M., Foley, J. F., Maronpot, R. R., and Anderson, M. W., Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine, Exp. Lung Res., 17, 263, 1991.
    • (1991) Exp. Lung Res. , vol.17 , pp. 263
    • Belinsky, S.A.1    Devereaux, T.R.2    White, C.M.3    Foley, J.F.4    Maronpot, R.R.5    Anderson, M.W.6
  • 75
    • 0027333129 scopus 로고
    • G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents
    • Ronai, Z. A., Gradia, S., Peterson, L. A., and Hecht, S. S., G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents, Carcinogenesis, 14, 2419, 1993.
    • (1993) Carcinogenesis , vol.14 , pp. 2419
    • Ronai, Z.A.1    Gradia, S.2    Peterson, L.A.3    Hecht, S.S.4
  • 76


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