Regional expression of Par-4 mRNA and protein after fluid percussion brain injury in the rat

Experimental Neurology

Volumn 170, Issue 1, 2001, Pages 140-148

  Dhillon, Harbhajan S ^a   Dong, Gao Xiang ^a   Yurek, David M ^a   Estus, Steven ^a   Rangnekar, Vivek M ^a   Dendle, Peter ^a   Prasad, Renuka M ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Brain injury; Fluid percussion; Prostate apoptosis response 4 protein

Indexed keywords

MESSENGER RNA; PROSTATE APOPTOSIS RESPONSE 4 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN INJURY; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0034954122     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7685     Document Type: Article

References (61)

1. Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade
2. Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues
3. Regional levels of phospholipase Cγ after fluid percussion brain injury in the rat
4. Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: Actions prior to mitochondrial dysfunction and caspases activation
5. Single-step method of RNA isolation by acid gaunidinium thiocyanate-phenol-chloroform extraction
6. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats
7. Caspase-3 mediated neuronal death after traumatic brain injury in rats
8. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: Possible role in spatial memory deficits
9. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period
10. Delayed brain injury: Secondary insults
11. Mild traumatic brain injury enhances muscarinic receptor-linked inositol phosphate production in rat hippocampus
12. 2 levels in rats
13. Regional levels of free fatty acids Evans blue extravasation after experimental brain injury
14. Activation of phosphatidylinositol bisphosphate signal transduction pathway after experimental brain injury: A lipid study
15. Regional concentrations of cyclic nucleotides after experimental brain injury
16. 4 after experimental brain injury in anesthetized rats
17. Time course of secondary injury factors after experimental brain injury
18. Severity of experimental brain injury on lactate and free fatty acid accumulation and Evan's blue extravasation in the rat cortex and hippocampus
19. The product of Par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
20. Participation of Par-4 in degeneration of dopaminergic neurons in models of Parkinson's disease
21. Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury
22. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
23. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
24. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
25. Analysis of acetylcholine release following concussive brain injury in the rat
26. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
27. Neurotransmitter-mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids
28. 2: A marker for lipid peroxidation after experimental brain injury
29. Delayed phospholipid degradation in rat brain after traumatic brain injury
30. Secondary injury and acidosis
31. A novel repressor, Par-4 modulates transcription and growth suppression functions of the Wilms tumor suppressor WT1
32. μ-Calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury
33. Mechanisms of calpain proteolysis following traumatic brain injury: Implications for pathology and therapy: A review and update
34. Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain
35. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
36. Lactate accumulation following concussive brain injury: The role of tonic fluxes induced by excitatory amino acids
37. Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats
38. The biochemistry of programmed cell death
39. Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
40. Effects of muscarinic receptor antagonism on the phosphatidylinositol bisphosphate signal transduction pathway after experimental brain injury
41. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
42. Biochemical determinants of apoptosis and necrosis
43. Traumatic brain injury in the rat: Alterations in brain lactate and pH as characterized by 1H and 31P nuclear magnetic resonance
44. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998
45. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
46. Alterations in brain protein kinase C after experimental brain injury
47. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model
48. Regional calpain and caspases-3 proteolysis of alpha-spectrum after traumatic brain injury
49. Enhanced phosphodiestric breakdown of phosphatidylinositol bisphosphate after experimental brain injury
50. Regional levels of lactate and norepinephrine after experimental brain injury
51. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein
52. Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4
53. BCL-2 over-expression attenuates cortical cell loss after traumatic brain injury in the rat
54. Evidence for apoptotic cell death after experimental traumatic brain injury in the rat
55. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat
56. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and independent prostate cells
57. Expression and function of the leucine zipper protein Par-4 in apoptosis
58. Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat
59. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
60. Immunohistochemical detection of the lipid peroxidation product 4-hydroxynonenal after experimental brain injury in the rat
61. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat