Genome-wide analyses on loss of heterozygosity in hepatocellular carcinoma in Southern China

Journal of Hepatology

Volumn 34, Issue 6, 2001, Pages 840-849

  Li, Sheng Ping ^a   Wang, Hui Yun ^a   Li, Jing Qin ^a   Zhang, Chang Qing ^a   Feng, Qi Sheng ^a   Huang, Ping ^a   Yu, Xin Juan ^a   Huang, Li Xi ^a   Liang, Qi Wang ^a   Zeng, Yi Xin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Loss of heterozygosity; Metastasis; Microsatellite marker

Indexed keywords

ARTICLE; CHINA; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER METASTASIS; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ALLELES; CARCINOMA, HEPATOCELLULAR; CHILD; CHINA; CHROMOSOMES, HUMAN; FEMALE; GENOME, HUMAN; HEPATITIS B; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMERASE CHAIN REACTION;

EID: 0034954039     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00047-2     Document Type: Article

References (78)

1. Hepatocellular carcinoma
2. From hepatitis to hepatoma: Lessons from type B hepatitis
3. Molecular biomarkers for aflatoxins: From adducts to gene mutations to human liver cancer
4. Hepatocellular carcinoma: From gene to public health
5. Genetic alterations during colorectal tumor development
6. Hepatitis C and B viruses in hepatitis B surface antigen negative hepatocellular carcinoma
7. A second-generation linkage map of the human genome
8. Biology of hepatocellular carcinoma
9. Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma
10. Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas
11. Allelotype study of primary hepatocellular carcinoma
12. p53 gene mutation spectrum in hepatocellular carcinoma
13. p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis
14. Genetic alteration in hepatocellular carcinomas: Association between loss of chromosome 4q and p53 gene mutations
15. Allelotype of colorectal carcinomas
16. Allelotype of pancreatic adenocarcinoma using xenograft enrichment
17. Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas
18. Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: Association with elevated alpha-fetoprotein production
19. Accumulation of genetic changes during development and progression of hepatocellular carcinoma: Loss of heterozygosity of chromosome arm 1p occurs at an early stage of hepatocarcinogenesis
20. A cell cycle regulatory potentially involved in genesis of many tumor-types
21. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
22. Identification of the breast cancer susceptibility gene BRCA2
23. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
24. Loss of heterozygosity in hepatocellular carcinoma
25. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China
26. Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinoma
27. Comprehensive allelotyping of human hepatocellular carcinoma
28. Allelotype analysis of hepatocellular carcinoma
29. Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan
30. A comprehensive genetic map of the human genome based on 5264 microsatellites
31. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma
32. Mutilcentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern
33. Genetic changes and histopathological grades in human hepatocellular carcinomas
34. Integration of hepatitis B virus and alteration of the 1p36 region found in cancerous tissue of primary hepatocellular carcinoma with virus replication evidenced only in noncancerous cirrhotic tissue
35. Allelotype of head and neck squamous cell carcinoma
36. Allelotype analysis of cervical carcinoma
37. Loss of heterozygosity at locus F13b on chromosome 1q in human medulloblastoma
38. Concerted nonsyntenic allelic losses in hyperploid hepatocellular carcinoma as determined by a high-resolution allelotype
39. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
40. Identification of a 1-cM region of common deletion on 4q35 associated with progression of hepatocellular carcinoma
41. PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3
42. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: Relationship to disease stage, tumor size, and cirrhosis
43. Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer
44. Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma
45. A common region of allelic loss on chromosome region 3p25.3-26.3 in nasopharyngeal carcinoma
46. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation
47. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
48. M6p/IGF2R gene is mutated in human hepatocellular carcinoma
49. Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from Southern China
50. Mutation in the BRCA2 gene in hepatocellular carcinomas
51. Deletions of chromosome 13q, mutations in retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma
52. Frequent allelic loss on chromosome 9 in hepatocellular carcinoma
53. Alterations of pl6-pRB pathway and chromosome locus 9p21-9p22 in non-small-cell lung carcinomas: Relationship with p53 and MDM2 protein expression
54. Role of the p16 tumor suppressor gene in cancer
55. Adnine phosphoribosyl transferase (APRT)
56. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma
57. Deletion of Ecadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas
58. The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19
59. Deletion in human chromosome arms 11p and 13q in primary hepatocellular carcinomas
60. Frequent loss of chromosome 8p in hepatitis B virus-positive hepatocellular carcinomas from China
61. Comprehensive allelotype study of hepatocellular carcinoma: Potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors
62. Accumulation of genetic alterations in a human hepatoma cell line transfected with hepatitis B virus
63. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features
64. The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma
65. Expression of human nm23-H1 and nm23-H2 protein in hepatocellular carcinoma
66. mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential
67. CD44 is expressed in hepatocellular carcinomas showing vascular invasion
68. Cadherin involved in the intrahepatic metastasis of hepatocellular carcinoma
69. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential
70. Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma
71. Relationship between loss of heterozygosity at microsatellite loci and computerized nuclear morphometry in hepatocellular carcinoma
72. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
73. Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma
74. Aberrant FHIT transcripts in hepatocellular carcinomas
75. Aberrant fragile histidine triad gene transcripts in primary hepatocellular carcinoma and liver cirrhosis
76. Alterations of the FHIT gene in human hepatocellular carcinoma
77. Different gene expression of MDM2, GAGE-l, -2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia