Increased brain serotonin synthesis in migraine

Neurology

Volumn 53, Issue 7, 1999, Pages 1473-1479

  Chugani, D C ^a,b   Niimura, K ^a   Chaturvedi, S ^a   Muzik, O ^a   Fakhouri, M ^a   Lee, M L ^a   Chugani, H T ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

Migraine; Neuroimaging; Positron emission tomography; Serotonin; 11C methyl L tryptophan

Indexed keywords

N METHYLTRYPTOPHAN; SUMATRIPTAN;

ADULT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN MAPPING; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HUMAN; MIGRAINE; NEUROTRANSMITTER RELEASE; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROPHYLAXIS; SEROTONIN BRAIN LEVEL; SEROTONIN METABOLISM;

EID: 0032716874     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.7.1473     Document Type: Article

References (40)

1. Stewart WF, Lipton RB, Celentano DD, et al. Prevalence of migraine headache in the United States. JAMA 1992;267:64-69.
2. Lipton RB, Stewart WF. Migraine in the United States: epidemiology and health care utilization. Neurology 1993;43(suppl 3):6-10.
3. Lance JW. History of involvement of 5-HT in primary headaches. In: Olesen J, Saxena PR, eds. 5-hydroxytryptamine mechanisms in primary headaches. New York: Raven Press, 1992:19-28.
4. Silberstein SD. Serotonin (5-HT) and migraine. Headache 1994;34:408-417.
5. Peroutka SJ. Developments in 5-hydroxytryptamine receptor pharmacology in migraine. Neurol Clin 1990;8:829-838.
6. The Subcutaneous Sumatriptan International Study Group. Treatment of migraine attacks with sumatriptan. N Engl J Med 1991;325:316-321.
7. Curran DA, Lance JW. Clinical trial of methysergide and other preparations in the management of migraine. J Neurol Neurosurg Psychiatry 1964;27:463-469.
8. Martucci N, Manna V, Agnoli A. Antidepressant drugs and migraine. Cephalalgia 1985;5(suppl 2):225-228.
9. Adly C, Straumanis J, Chesson A. Fluoxetine prophylaxis of migraine. Headache 1992;32:101-104.
10. Panconesi A, Sicuteri R. Headache induced by serotonergic agonists: a key to the interpretation of migraine pathogenesis? Cephalalgia 1997;17:3-14.
11. Muck-Seler D, Deanovic Z, Dupelj M. Serotonin-releasing factors in migrainous patients. Advances in neurology, vol. 33. 1982:257-264.
12. Ferrari MD, Saxena PR. On serotonin and migraine: a clinical and pharmacological review. Cephalalgia 1993;13:151-165.
13. Ferrari MD, Odink J, Tapparelli C, et al. Serotonin metabolism in migraine. Neurology 1989;39:1239-1242.
14. Muzik O, Chugani DC, Chakraborty PK, et al. Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab 1997;17:659-669.
15. Nishizawa S, Benkelfat C, Young SN, et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 1997;94:5308-5313.
16. Chugani DC, Muzik O, Chakraborty PK, et al. Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse 1998;28:33-43.
17. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgia, and facial pain. Cephalalgia 1988;8(suppl 7):1-96.
18. Mathew NT, Saper JR, Silberstein SD, et al. Migraine prophylaxis with divalproex. Arch Neurol 1995;52:281-286.
19. 11C]methyl-L-tryptophan. Nucl Med Biol 1996;23:1005-1008.
20. Wolf WA, Kuhn DM. The uptake and release of tryptophan and serotonin: an HPLC method to study the flux of endogenous 5-hydroxyindoles through synaptosomes. J Neurochem 1986;46:61-67.
21. Muzik O, Behrendt DB, Mangner TJ, Chugani HT. Design of a pediatric protocol for quantitative brain FDG studies with PET not requiring invasive blood sampling. J Nucl Med 1994; 35:104P. Abstract.
22. Suhonen-Polvi H, Ruotsalainen U, Kinnala A, et al. FDG-PET in early infancy: simplified quantification methods to measure cerebral glucose utilization. J Nucl Med 1995;36:1249-1254.
23. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
24. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publishers, 1988.
25. Diener H-C. Positron emission tomography studies in headache. Headache 1997;37:622-625.
26. Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995;1:658-660.
27. Ferrari MD, Haan J, Blokland JA, et al. Cerebral blood flow during migraine attacks without aura and effect of sumatriptan. Arch Neurol 1995;52:135-139.
28. Woods RP, Iacoboni M, Mazziotta JC. Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994;331:1689-1692.
29. Chabriat H, Tehindrazanarivelo A, Vera P, et al. 5HT2 receptors in cerebral cortex of migraineurs studied using PET and 18F-fluorosetoperone. Cephalalgia 1995;15:104-108.
30. Hoyer D, Schoeffter P. 5-HT receptors: subtypes and second messengers. J Recept Res 1991;11:197-214.
31. Middlemiss DN, Neill J, Tricklebank MD. Subtypes of the 5-HT receptor involved in hypothermia and forepaw treading induced by 8-OH-DPAT. Br J Pharmacol 1985;85:251P. Abstract.
32. Lesch KP, Poten B, Sohnle K, Schulte HM. Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans. Eur J Clin Pharmacol 1990;39:17-19.
33. Haigler HJ, Aghajanian GK. Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input. Pharmacol Exp Ther 1974;188:688-699.
34. Blier P, Serrano A, Scatton B. Differential responsiveness of the rat dorsal and median raphe 5-HT systems to 5-HT1 receptor agonists and p-chloroamphetamine. Synapse 1990;5: 120-133.
35. Sprouse JS, Aghajanian GK. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1987;1:3-9.
36. Invernizzi R, Carli M, Di Clemente A, Samanin R. Administration of 8-hydroxy-2-(Di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity. J Neurochem 1991;56:243-247.
37. Casanovas JM, Artigas F. Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. J Neurochem 1996;67:1945-1952.
38. Romero L, Bel N, Artigas F, et al. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology 1996;15:349-360.
39. Smith QR, Monna S, Aoyagi M, Rapoport SI. Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 1987;49:1651-1658.
40. Lauritzen M, Olesen J. Regional cerebral blood flow during migraine attacks by xenon-133 inhalation and emission tomography. Brain 1984;107:447-461.