GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast

Molecular and Cellular Biology

Volumn 21, Issue 14, 2001, Pages 4568-4578

  Stafford, G A ^a   Morse, R H ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; HISTONE ACETYLTRANSFERASE; PROTEIN VP16; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHROMATIN STRUCTURE; EPISOME; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; YEAST;

ACETYLTRANSFERASES; BINDING SITES; CHROMATIN; DNA-BINDING PROTEINS; FUNGAL PROTEINS; HERPES SIMPLEX VIRUS PROTEIN VMW65; HISTONE ACETYLTRANSFERASES; NUCLEOSOMES; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EUKARYOTA; SACCHAROMYCETALES;

EID: 0034948932     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.14.4568-4578.2001     Document Type: Article

References (86)

1. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
2. Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast
3. Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements
4. Binding of Gal4p and bicoid to nucleosomal sites in yeast in the absence of replication
5. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
6. Continuous and widespread roles for the Swi-Snf complex in transcription
7. The many HATs of transcription coactivators
8. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
9. Activation domain-mediated enhancement of activator binding to chromatin in mammalian cells
10. The yeast SWI-SNF complex facilitates binding of a transcriptional activator to nucleosomal sites in vivo
11. Signaling to chromatin through histone modifications
12. Evidence for functional binding and stable sliding of the TATA binding protein on nonspecific DNA
13. The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure
14. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo
15. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
16. Two distinct nucleosome alterations characterize chromatin remodeling at the Saccharomyces cerevisiae ADH2 promoter
17. The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex
18. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae
19. Gene activation by recruitment of the RNA polymerase II holoenzyme
20. GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo
21. The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo
22. RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter
23. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
24. Folding of the DNA double helix in chromatin-like structures from simian virus 40
25. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
26. Yeast Gen5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
27. Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast
28. Chromatin remodelling at the PHO8 promoter requires SWI-SNF and SAGA at a step subsequent to activator binding
29. DMSO-enhanced whole cell yeast transformation
30. Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure
31. Dissecting the regulatory circuitry of a eukaryotic genome
32. Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes
33. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
34. Positioned nucleosomes inhibit Dam methylation in vivo
35. Global role for chromatin remodeling enzymes in mitotic gene expression
36. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
37. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
38. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
39. A positive role for histone acetylation in transcription factor access to nucleosomal DNA
40. Organization of the GAL1-GAL10 intergenic control region chromatin
41. Fusion of GAL4-VP16 to a steroid-binding domain provides a tool for gratuitous induction of galactose-responsive genes in yeast
42. Functional similarity and physical association between GCN5 and ADA2: Putative transcriptional adaptors
43. GAL4 interacts with TATA-binding protein and coactivators
44. Role of nucleosome remodeling factor NURF in transcriptional activation of chromatin
45. Nucleosome structure of the yeast CHA1 promoter: Analysis of activation-dependent chromatin remodeling of an RNA-polymerase-II-transcribed gene in TBP and RNA pol II mutants defective in vivo in response to acidic activators
46. Nucleosome disruption by transcription factor binding in yeast
47. Topoisomer heterogeneity of plasmid chromatin in living cells
48. yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex
49. Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator
50. Non-random cleavage of SV40 DNA in the compact minichromosome and free in solution by micrococcal nuclease
51. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
52. Mutations in chromatin components suppress a defect of Gens protein in Saccharomyces cerevisiae
53. Recruitment of chromatin remodeling machines
54. Promoter targeting and chromatin remodeling by the SWI/SNF complex
55. Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression
56. Transcriptional activation by recruitment
57. Mutations in both the structured domain and N-terminus of histone H2B bypass the requirement for Swi-Snf in yeast
58. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter
59. Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes
60. Yeast α2 repressor positions nucleosomes in TRP1/ARS1 chromatin
61. Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4
62. SWI-SNF complex participation in transcriptional activation at a step subsequent to activator binding
63. Artificially recruited TATA-binding protein fails to remodel chromatin and does not activate three promoters that require chromatin remodeling
64. Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription
65. Chromatin reconstituted from tandemly repeated cloned DNA fragments and core histones: A model system for study of higher order structure
66. Chromatin remodeling by transcriptional activation domains in a yeast episome
67. Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays
68. The nucleosome remodeling complex, Snf/Swi, is required for the maintenance of transcription in vivo and is partially redundant with the histone acctyltransferase, Gcn5
69. The Gcn5 bromodomain co-ordinates nucleosome remodelling
70. Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo
71. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
72. The activation domain of GALA protein mediates cooperative promoter binding with general transcription factors in vivo
73. Chromatin remodeling during Saccharomyces cerevisiae ADH2 gene activation
74. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
75. Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
76. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
77. Ssn6-Tup1 interacts with class I histone deacetylases required for repression
78. Construction of a set of convenient Saccharomyces cerevisiae strains that arc isogenic to S288C
79. The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I
80. TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast
81. Quantitation of putative activator-target affinities predicts transcriptional activating potentials
82. Gal4p-mediated chromatin remodeling depends on binding site position in nucleosomes but does not require DNA replication
83. Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae
84. Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators
85. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
86. A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter