Methylation of the 5' CpG island of the endothelin B receptor gene is common in human prostate cancer

Cancer Research

Volumn 57, Issue 1, 1997, Pages 35-37

  Nelson, Joel B ^a,d   Lee, Wen Hsiang ^a   Nguyen, Son H ^a   Jarrard, David F ^a   Brooks, James D ^a   Magnuson, Scott R ^c   Opgenorth, Terry J ^c   Nelson, William G ^b   Bova, G Steven ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c ABBOTT LABORATORIES   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN B RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; METHYLATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENTIAL ANALYSIS; SOUTHERN BLOTTING;

DINUCLEOSIDE PHOSPHATES; HUMANS; MALE; METHYLATION; PROSTATIC NEOPLASMS; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; REGULATORY SEQUENCES, NUCLEIC ACID; TUMOR CELLS, CULTURED;

EID: 0031026396     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Nelson, J. B., Hedican, S. P., George, D. J., Reddi, A. H., Piantadosi, S., Eisenberger, M. A., and Simons, J. W. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat. Med., 1: 944-949, 1995.
2. Nelson, J. B., Chan-Tack, K., Hedican, S. P., Magnuson, S. R., Opgenorth, T. J., Bova, G. S., and Simons, J. W. Endothelin production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res., 56: 663-668, 1996.
3. B receptors in rats. Biochem. Biophys. Res. Commun., 199: 1461-1465, 1994.
4. Yohn, J. J., Smith, C., Stevens, T., Morelli, J. G., Shurnas, L. R., Walchak, S. J., Hoffman, T. A., Kelley, K. K., Escobedo-Morse, A., Yanagisawa, M., Kane, M. A., and Zamora, M. R. Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor. Biochim. Biophys. Acta, 1224: 454-458, 1994.
5. Bird, A. P. CpG-rich islands and the function of DNA methylation. Nature (Lond.), 321: 209-213, 1986.
6. Arai, H., Nakao, K., Takaya, K., Hosoda, K., Ogawa, Y., Nakanishi, S., and Imura, H. The human endothelin-B receptor gene: structural organization and chromosomal assignment. J. Biol. Chem., 268: 3463-3470, 1993.
7. Lee, W-H., Morton, R. A., Epstein, J. I., Brooks, J. D., Campbell, P. A., Bova, G. S., Hseih, W-S., Isaacs, W. B., and Nelson, W. G. Cytidine methylation of regulatory sequences near the π-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc. Natl. Acad. Sci. USA, 91: 11733-11737, 1994.
8. Ogawa, Y., Nakao, K., Aria, H., Nakagawa, O., Hosoda, K., Suga, S., Nakanishi, S., and Imura, H. Molecular cloning of a non-isopeptide-selective human endothelin receptor. Biochem. Biophys. Res. Commun., 178: 248-255, 1991.
9. Razin, A., and Kafri, T. DNA methylation from embryo to adult. Prog. Nucleic Acid Res. Mol. Biol., 48: 53-81, 1994.
10. Antequera, F., Boyes, B., and Bird, A. P. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell, 62: 503-514, 1990.
11. Baylin, S. B., Makos, M., Wu, J. J., Yen, R. W., de Bustros, A., Vertino, P., and Nelkin, B. D. Abnormal pattern of DNA methylation in human neoplasia: potential consequences for tumor progression. Cancer Cells (Cold Spring Harbor), 3: 383-390, 1991.
12. Jones, P. A. DNA methylation errors and cancer. Cancer Res., 56: 2463-2467, 1996.
13. Rubanyi, G. M., and Polokoff, M. A. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev., 46: 325-415, 1994.
14. Hirata, Y., Emori, T., Eguchi, S., Kanno, K., Imai, T., Ohta, K., and Marumo, F. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest., 91: 1367-1373, 1993.
15. Knudson, A. G., and Strong, L. C. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 68: 820-823, 1971.
16. Puffenberger, E. G., Hosoda, K., Washington, S. S., Nakao, K., deWit, D., Yanagisawa, M., and Chakravarti, A. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell, 79: 1257-1266, 1994.
17. Brooks, J. D., Bova, G. S., and Isaacs, W. B. Retinoblastoma gene allelic loss in human prostate cancers. Prostate, 26: 35-39, 1995.
18. Cher, M. L., Bova G. S., Moore D. H., Small, E. J., Carroll, P. R., Pin, S. S., Epstein, J. I., Isaacs, W. B., and Jensen, R. H. Genetic alteration in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res., 56: 3091-3102, 1996.
19. Little, M., and Wainwright, B. Methylation and p16: suppressing the suppressor. Nat. Med., 1: 633-634, 1995.
20. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidranski, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.