Effects of traumatic brain injury on the cholinergic system in the rat

Journal of Neurotrauma

Volumn 13, Issue 8, 1996, Pages 457-463

  Gorman, Linda K ^a   Fu, Karen ^b   Hovda, Daved A ^b   Murray, Micah ^a   Traystman, Richard J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

basal forebrain; fluid percussion; hippocampus; medial septal area; septohippocampal

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN REGION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; RAT; SEPTUM PELLUCIDUM;

EID: 0029812039     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1996.13.457     Document Type: Article

References (33)

1. BECKER, D.P., SHOOK, B.L., GORMAN, L.K., and KATAYAMA, Y. (1989). Histochemical and behavioral changes following experimental brain injury in rat. Soc. Neurosci. Abstr. Part I, 131.
2. BIGL, V., WOOLF, N.J., and BUTCHER, L.L. (1982). Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis. Brain Res. Bull. 8, 727-749.
3. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. COOPER, J.R., BLOOM, F.E., and ROTH, R.H. (1991). The Biochemical Basis of Neuropharmacology. Oxford University Press, New York.
5. DEANGELIS, M.M., HAYES, R.L., and LYETH, B.C. (1994). Traumatic brain injury causes a decrease in M2 muscarinic cholinergic receptor binding in the rat brain. Brain Res. 653, 39-44.
6. DIXON, C.E., LYETH, B.G., POVLISHOCK, J.T., FINDLING, R.L., HAMM, R.J., MARMAROU, A., YOUNG, H.F., and HAYES, R.L. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
7. 3H]choline uptake but not extracellular choline levels in rats. Neurosci. Lett. 180, 127-130.
8. DIXON, C.E., HAMM, R.J., TAFT, W.C., and HAYES, R.L. (1994b). Increased anticholinergic sensitivity following closed skull impact and controlled cortical impact traumatic brain injury in the rat. J. Neurotrauma 11(3), 275-287.
9. DUNNETT, S.B. (1985). Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats. Psychopharmacology 87, 357-363.
10. FONNUM, F. (1969). Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. Biochem. J. 115, 465-472.
11. GALLAGHER, M., BURWELL, R.D., KODSI, M.H., MCKINNEY, M., SOUTHERLAND, S., VELLAROUNDTREE, L., and LEWIS, M.H. (1990). Markers for biogenic amines in the aged rat brain: Relationship to decline in spatial learning ability. Neurobiol. Aging 11(5), 507-514.
12. GAYKEMA, R.P.A., LUITEN, P.G.M., NYAKAS, C., and TRABER, J. (1990). Cortical projection patterns of the medial septum-diagonal band complex. J. Comp. Neurol. 293, 103-124.
13. GAYKEMA, R.P.A., VAN WEEGHEL, R.V., HERSH, L.B., and LUITEN, P.G.M. (1991). Prefrontal cortical projections to the cholinergic neurons in the basal forebrain. J. Comp. Neural. 303, 563-583.
14. GORMAN, L.K., FU, K., HOVDA, D.A., BECKER, O.P., and KATAYAMA, Y. (1989). Analysis of acetylcholine release following concussive brain injury in the rat. J. Neurotrauma 6, 203.
15. GORMAN, L.K., SHOOK, B.L., and BECKER, O.P. (1993). Traumatic brain injury produces impairments in long-term and recent memory. Brain Res. 614(1-2), 29-36.
16. GORMAN, L.K., JOUNG, K.P., FRICK. K.M., BAXTER, M.G., MARKJOWSKA, A.L., and PRICE, D.L. (1995). Presynaptic cholinergic markers in the rat brain: Relationships with age and behavioral status. Soc. Neurosci. Abstr. 21(1), 471.
17. HAYES, R.L., JENKINS, L.W., and LYETH, B.G. (1992). Neurotransmitter-mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids. J. Neurotrauma 9(1), S173-S187.
18. JIANG, J.Y., LYETH, B.G., DELAHUNTY, T.M., PHILLIPS, L.L., and HAMM, R.J. (1994). Muscarinic cholinergic receptor binding in rat brain at 15 days following traumatic brain injury. Brain Res. 651, 123-128.
19. LAMOUR, Y., DUTAR, P., and JOBERT, A. (1984). Septohippocampal and other medial septal-diagonal band neurons: Electrophysiological and pharmacological properties. Brain Res. 309, 227-239.
20. LERANTH, C., DELLER, T., and BUZSAKI, G. (1992). Intraseptal connections redefined: Lack of lateral septum to medial septum path. Brain Res. 583, 1-11.
21. LUINE, V., and HEARNS, M. (1990). Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT. Brain Res. 523(2), 321-324.
22. LYETH, B.G., and HAYES, R.L. (1992). Cholinergic and opioid mediation of traumatic brain injury. J. Neurotrauma 9(2), S463-S474.
23. LYETH, B.G., DIXON, C.E., HAMM, R., JENKINS, L., YOUNG, H., STONNINGTON, H., and HAYES, R. (1988a). Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat. Brain Res. 488, 88-97.
24. LYETH, B.G., DIXON, C.E., JENKLNS, L., YOUNG, H., STONNINGTON, H., and HAYES, R. (1988b). Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Res. 452, 39-97.
25. LYETH, E.G., JENKINS, L.W., HAMM, R.J., DIXON, C.E., PHILLIPS, L.L., CLIFTON, G.L., YOUNG, H.F., and HAYES, R.L. (1990). Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res. 526, 249-258.
26. LYETH, B.C., JIANG, J.Y., DELAHUNTY, T.M., PHILLIPS, L.L., and HAMM, R.J. (1994). Muscarinic cholinergic receptor binding in rat brain following traumatic brain injury. Brain Res. 640, 240-245.
27. McINTOSH, T.K. (1994). Neurochemical sequelae of traumatic brain injury: Therapeutic implications, Cerebrovasc. Brain Metab. Rev. 6, 109-162.
28. OLTON, D.S., and PAPAS, B.C. (1979). Spatial memory and hippocampal function. Neuropsychologia 17, 669-682.
29. OLTON, D.S., GIVENS, B.S., MARKOWSKA, A.L., SHAPIRO, M., GOLSKI, S., and GORMAN, L.K. (1993). Mnemonic functions of the septo-hippocampal system, in: Memory: Organization and Locus of Change. L.R. Squire, G. Lynch, L.R. Weinberger, and J.L. McGaugh (eds.). Oxford University Press, Oxford.
30. ROBBINS, T.W., EVERITT, B.J., MARSTON, H.M., WILKINSON, J., JONES, G.H., and PAGE, K.J. (1989). Comparative effects of ibotenic acid and quisqualic acid-induced lesions of substantia innominata on attentional function in the rat: Further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes. Behav. Brain Res. 35, 221-240.
31. RYLETT, R.J., GODDARD, S., SCHMIDT, B.M., and WILLIAMS, L.R. (1993). Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats. J. Neurosci. 13(9), 3956-3963.
32. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., CLAUSSEN, B., and MCINTOSH, T.K. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. J. Neurotrauma 8(4), 259-269.
33. STUSS, D.T., STETHEM, L.L., PICTON, T.W., LEECH, E.E., and PELCHAT, G. (1989). Traumatic brain injury, aging and reaction time. Can. J. Neurol. Sci. 16, 161-167.