Rivastigmine, a Brain-Selective Acetylcholinesterase Inhibitor, Ameliorates Cognitive and Motor Deficits Induced by Closed-Head Injury in the Mouse

Journal of Neurotrauma

Volumn 15, Issue 4, 1998, Pages 231-237

  Chen, Yun ^a   Shohami, Esther ^a   Constantini, Shlomi ^b   Weinstock, Marta ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

brain edema; cholinergic activity; closed head injury; mecamylamine; mice; scopolamine; spatial memory

Indexed keywords

EID: 85016855413     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.1998.15.231     Document Type: Article

References (43)

1. ANAND, R., GHARABAWI, G., and ENZ, A. (1996). Efficacy and safety results of the early phase studies with Rivastigmine (ENA-713) in Alzheimer's disease: An overview. J. Drug. Dev. Clin. Pract. 8, 1–8.
2. BROOKS, D.N. (1975). Long- and short-term memory in head injured patients. Cortex 11, 329–340.
3. CAPRUSO, D.X., and LEVIN, H.S. (1992). Cognitive impairment following closed head injury. Neurologic. Clin. 10, 879–893.
4. CHEN, Y., CONSTANTINI, S., TREMBOVLER, V., WEINSTOCK, M., and SHOHAMI, E. (1996). An experimental model of closed head injury in mice: Pathophysiology, histopathology and cognitive deficits. J. Neurotrauma 13, 557–569.
5. CHEN, Y., SHOHAMI, E., BASS, R., and WEINSTOCK, M. (1998). Cerebro-protective effects of ENA713, a novel acetylcholinesterase inhibitor, in closed head injury in the rat. Brain Res. (in press).
6. DIXON, C.E., HAMM, R.J., TAFT, W.C., and HAYES, R.L. (1994). Increased anticholinergic sensitivity following closed skull impact and controlled cortical impact traumatic brain injury in the rat. J. Neurotrauma 11, 275–287.
7. DIXON, C.E., MA, X., and MARION, D. (1996). Reduced evoked release of acetylcholine in the cortex of awake, freely-moving rats following traumatic brain injury. J. Neurotrauma 13,615.
8. DUNNETT, S.B., WAREHAM, A.T., and TORRES, E.M. (1990). Cholinergic blockade in the prefrontal cortex and hippocampus disrupts short-term memory in rats. NeuroReport 1, 61–64.
9. ENZ, A., AMSTUTZ, R., HOFFMAN, A., GMELIN, G., and KELLY, P.H. (1989). Pharmacological properties of the preferentially centrally-acting acetylcholinesterase inhibitor SDZ ENA713. In Pharmacological Interventions on Central Cholinergic Mechanisms in Senile Dementia. H. Kewitz, T. Thomsen, and U. Bickel (eds.). Zuckschwerdt: Munich, pp. 271–277.
10. FADEN, A.I. (1993). Experimental neurobiology of central nervous system injury. In Critical Reviews in Neurobiology. C.B. Nemeroff (ed.), CRC Press: Boca Raton FL pp. 175–186.
11. GENTLEMAN, S.M., GRAHAM, D.I., and ROBERT, G.W. (1993). Molecular pathology of head trauma: Altered APP metabolism and the aetiology of Alzheimer's disease. Progr. Brain Res. 96, 237–246.
12. GORMAN, L.K., FU, K., HOVDA, D.A., BECKER, D.P., and KATAYAMA, Y. (1989). Analysis of acetylcholine release following concussive brain injury in the rat. J. Neurotrauma 6, 203.
13. GORMAN, L.K., FU, K., HOVDA, D.A., MURRAY, M., and TRAYSTMAN, R.J. (1996). Effects of traumatic brain injury on the cholinergic system in the rat. J. Neurotrauma 13, 457–463.
14. HAMM, R.J., TEMPLE, M.D., PIKE, B.R., O'DELL, D.M., BUCK, D.L., and LYETH, B.G. (1996). Working memory deficits following traumatic brain injury in the rat. J. Neurotrauma 13, 317–323.
15. KLATZO, I. (1967). Neuropathological aspects of brain edema. J. Neuropath. Exp. Neural. 26, 1–14.
16. LEONARD, J.R., MARIS, D.O.A., and GRADY, M.S. (1994). Fluid percussion injury causes loss of forbrain choline acetyl transferase and nerve growth factor receptor immunoreactive cells in the rat. J. Neurotrauma 4, 379–392.
17. LEVIN, E.D., CASTONGUAY, M., and ELLISON, G. (1987). Effects of the nicotinic receptor blocker, mecamylamine on radial arm-maze performance in rats. Behav. Neural. Biol. 48, 206–212.
18. LOBATO, R., SARABIA, R., CORDOBES, F., RIVAS, J., ADRADOS, A., CARGRERE, A. et al. (1988). Posttraumatic cerebral hemispheric swelling. J. Neurosurg. 68, 417–423.
19. LYETH, B.G., DIXON, C.E., JENKINS, L.W., HAMM, R.J., ALBERICO, A. YOUNG, H.F., STONNINGTON, H.F., and HAYES, R.L. (1988). Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Res. 452, 39–48.
20. LYETH, B.G., JENKINS, L.W., and HAMM, R.J. (1990). Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res. 526, 249–258.
21. LYETH, B.G., RAY, M., HAMM, R.J., SCHNABEL, J., SAADY, J.J., POKLIS, A., JENKINS, L.W., GUDEMAN, S.K., and HAYES, R.L. (1992). Postinjury scopolamine administration in experimental traumatic brian injury. Brain Res. 569, 281–286.
22. LYETH, B.G., JIANG, J.Y., DELAHUNTY, T.M., PHILLIPS, L.L., and HAMM, R.J. (1994). Muscarinic cholinergic receptor binding in rat brain following traumatic brain injury. Brain Res. 640, 240–245.
23. MORTIMER, J.A., VAN DUIJN, C.M., CHANDRA, V. et al. (1991). Head trauma as a risk factor for Alzheimer's disease: A collaborative re-analysis of case-control studies. Int. J. Epidemiol. 20, (Suppl 20), S28-S35.
24. PIKE, B.R., and HAMM, R.J. (1995). Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 686, 37–43.
25. PIKE, B.R., and HAMM, R.J. (1997). Chronic administration of a partial muscarinic Mj receptor agonist attenuates decreases in forebrain choline acetyltransferase immunoreactivity following experimental brain trauma. Exptl. Neural. 147, 55–65.
26. RIMEL, R.W., GIORDANI, B., BARTH, J.T., and JANE, J.A. (1982). Moderate head injury: Completing the clinical spectrum of brain injury. Neurosurgery 11, 344–351.
27. SADOSHIMA, S., IBAYASHI, S., FUJII, K., NAGAO, T., SUGIMORI, H., and FUJISHIMA, M. (1995). Inhibition of acetylcholinesterase modulates the autoregulation of cerebral blood flow and attenuates ischemic brain metabolism in hypertensive rats. J. Cereb. Blood Flow Metab. 15, 845–851.
28. SCHMIDT, R.H. and GRADY, S. (1995). Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury. J. Neurosurg. 83, 496–502.
29. SCREMIN, O.U., and JENDEN, D.J. (1989). Focal ischemia enhances choline output and decreases acetylcholine output from rat cerebral cortex. Stroke 20, 92–95.
30. SCREMIN, O.U., SCREMIN, A.M.E., HEUSER, D., HUDGELL, R., ROMERO, E., and IMBOBO, B.P. (1993). Prolonged effects of cholinesterase inhibition with Eptastigmine on the cerebral blood flow-metabolism ratio of normal rats. J. Cereb. Blood Flow Metab. 13, 702–711.
31. SHAPIRA, Y., SHOHAMI, E., SIDI, A., SOFFER, D., FREEMAN, S., and COTEV, S. (1988). Experimental closed head injury in rats: Mechanical, pathophysiology and neurologic properties, Crit. Care Med. 16, 258–265.
32. SHAPIRA, Y., SETTON, D., ARTRU, A.A., and SHOHAMI, E. (1993). Blood-brain barrier permeability, cerebral edema and neurological function following closed head injury in rats. J. Anesth. Analg. 77, 141–148.
33. SHOHAMI, E., NOVIKOV, M., and BASS, R. (1995). Long-term effect of HU-211, a novel non-competitive NMD A antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. 674, 55–62.
34. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., CLAUSSEN, B., and McINTOSH, T.K. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. J. Neurotrauma 8, 259–269.
35. TANAKA, K., MIZUKAWA, K., OGAWA, N., and MORI, A. (1995). Post-ischemic administration of the aceylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus. Neurochem. Res. 20, 663–667.
36. TANAKA, K., OGAWA, N., MIZUKAWA, K., ASANUMA, M., KONDO, Y., NISHIBAYASHI, S., and MORI, A. (1994). Aceylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia. Neurochem. Res. 19, 117–122.
37. TSUJIMOTO, S.H., SAKAKI, T., MORIMOTO, T., And TOMINAGA, M. (1993). The effect of aceylcholinesterase inhibitor (SZD ENA 713) for r-CBF and focal cerebral ischemia. Acta Neurochir. (Wien) 124, 127–131.
38. WEINSTOCK, M., RAZIN, M., CHOREV, M., and TASHMA, Z. (1986). Pharmacological activity of novel acetylcholinesterase agents of potential use in the treatment of Alzheimer's disease. In Advances in Behavioral Biology. A. Fisher, I. Hanin, and C. Lachman (eds.), Plenum Press: New York, pp. 539–551.
39. WEINSTOCK, M., RAZIN, M., CHOREV, M., and ENZ, A. (1994). Pharmacological evaluation of phenyl-carbamates as CNS selective acetylcholinesterase inhibitors. J. Neural Transmission s43, 219–225.
40. WHITEHOUSE, P.J., PRICE, D.L., STRUBLE, R.G., CLARK, A.W., COYLE, J.T., and DELONG, M. (1982). Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215, 1237–1239.
41. VOGELS, O.J.M., BROERE, C.A.J., TER LAAK, H.J., TEN DONKELAAR, H.J., NIEUWENHUYS, R., and SCHULTE, B.P.M. (1990). Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease. Neurobiol. Aging 11, 3–13.
42. YAMAGUCHI, T., OZAWA, Y., SUZUKI, M., YAMAMOTO, M., NAKAMURA, T., and YAMAURA, A. (1996). Indeloxazine hydrochloride improves impairment of passive avoidance performance after fluid percussion brain injury in rats. Neuropharmacol. 35, 329–336.
43. ZAUNER, A., and BULLOCK, R. (1995). The role of excitatory amino acids in severe brain trauma: Opportunities for therapy: A review. J. Neurotrauma 12:547–554.