How do sickle cells become dehydrated?

Hematology Journal

Volumn 2, Issue 3, 2001, Pages 200-205

  Merciris, P ^a   Giraud, F ^a  

^a INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

Hemoglobin F; K C1 cotransport; KCa channels; Protein tyrosine kinase; Serine threonine phosphatase 2A; Sickle cells

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CASEIN KINASE II; ERYTHROCYTE BAND 3 PROTEIN; HEMOGLOBIN F; HEMOGLOBIN S; MAGNESIUM ION; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; POTASSIUM ION; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; SODIUM ION; TRANSFERRIN RECEPTOR;

ARTICLE; CELL STRUCTURE; CHANNEL GATING; CONTROLLED STUDY; DEHYDRATION; DEPHOSPHORYLATION; ERYTHROCYTE; HUMAN; HUMAN CELL; OXYGENATION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; SICKLE CELL; SICKLE CELL ANEMIA; SODIUM TRANSPORT; T LYMPHOCYTE;

ANEMIA, SICKLE CELL; BIOPOLYMERS; BODY WATER; CALCIUM; CALCIUM CHANNELS; CHLORIDE CHANNELS; DESICCATION; ENZYME INHIBITORS; ERYTHROCYTES, ABNORMAL; HEMOGLOBIN, SICKLE; HUMANS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MODELS, BIOLOGICAL; NA(+)-K(+)-EXCHANGING ATPASE; PHOSPHORIC MONOESTER HYDROLASES; POTASSIUM; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTORS, TRANSFERRIN; STAUROSPORINE;

EID: 0034930245     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200107     Document Type: Article

References (42)

1. Pathophysiology of sickle cell anemia
2. Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells
3. Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia
4. Cation transport and volume regulation in sickle red blood cells
5. 2+ levels of sickle cell anemia red cells
6. Regulation of erythrocyte cation and water content in sickle cell anemia
7. + exchange
8. 2+ modulation
9. 2+ permeability
10. Association between morphologic distortion of sickle cells and deoxygenation-induced cation permeability increase
11. Deoxygenation-induced cation fluxes in sickle cells IV: Modulation by external calcium
12. 2+ permeability in deoxygenated sickle cells
13. Sickling-induced binding of immunoglobulin to sickle erythrocytes
14. Uncoupling of the spectrin-based skeleton from the lipid bilayer in sickled red cells
15. 2+ permeability of human erythrocytes
16. Membrane stress increases cation permeability in red cells
17. Non-selective cation channels in sickle membrane spicules are inhibited by DIDS, a stilbene disulfonate drug which blocks sickling-induced cation fluxes in intact cells
18. Dehydration of transferrin receptor-positive sickle retinculocytes during continuous or cyclic deoxygenation: Role of K/Cl cotransport and extracellular calcium
19. The formation of transferrin receptor-positive sickle reticulocytes with intermediate density is not determined by fetal hemoglobin content
20. Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells
21. A mathematical model of the volume, pH, and ion content regulation in reticulocytes. Application to the pathophysiology of sickle cell dehydration
22. The involvement of the Ca-dependent K channel and of the K-Cl cotransport in sickle cell dehydration during cyclic deoxygenation
23. Dehydration of mature and immature sickle red blood cells during fast oxygenation/deoxygenation cycles: Role of KCl cotransport and extracellular calcium
24. Inhibition of K transport by divalent cations in sickle erythrocytes
25. Deoxygenation permeabilizes sickle cell anemia red cells to magnesium and reverses its gradient in the dense cells
26. Modulation of K-Cl cotransport in volume-clamped low-K sheep erythrocytes by pH, magnesium, and ATP
27. --cotransporter in normal and sickle human red blood cells
28. The effect of hemoglobin A and S on the volume- and pH-dependence of K-Cl cotransport in human erythrocyte ghosts
29. Molecular identification and expression of erythroid K: Cl cotransport in human and mouse erythroleukemic cells
30. Erythrocyte KCl cotransport: Properties and regulation
31. Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes
32. ++
33. Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport
34. Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport
35. Inhibition of deoxygenation-induced membrane protein dephosphorylation and cell dehydration by phorbol esters and okadaic acid in sickle cells
36. Involvement of deoxygenation-induced increase in tyrosine kinase activity in sickle cell dehydration
37. + channel in human erythrocytes and alters cell volume and filterability
38. + channels via endothelin B receptors in CD-1 mouse erythrocytes
39. 2 levels in sickle cell disease and acute vaso-occlusive sickle crisis
40. 2+ pump and K(Ca) channel in deoxygenated sickle cells
41. Vers les thérapeutiques des hémoglobinopathies ciblant le globule rouge
42. Sickle cell disease: Present and Future treatment