Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cells

Journal of Physiology

Volumn 511, Issue 1, 1998, Pages 225-234

  Gibson, J S ^a   Speake, P F ^a   Ellory, J C ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANOIC ACID; BUMETANIDE; CALCIUM ION; CALYCULIN A; CHLORIDE ION; HEMOGLOBIN A; MAGNESIUM ION; NITRENDIPINE; OUABAIN; OXYGEN; POTASSIUM ION; PROTON; UREA; POTASSIUM CHLORIDE COTRANSPORTER;

ARTICLE; CELL PH; CELL SWELLING; CHLORIDE TRANSPORT; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; OXYGEN TENSION; PATHOPHYSIOLOGY; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SICKLE CELL; EXTRACELLULAR CALCIUM; PH; PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SUBSTITUTION REACTION;

ANEMIA, SICKLE CELL; BUMETANIDE; CARBOXYLIC ACIDS; CARRIER PROTEINS; CHLORIDES; EGTAZIC ACID; ENZYME INHIBITORS; ERYTHROCYTES; HEMOGLOBIN A; HEMOGLOBIN, SICKLE; HUMANS; HYDROGEN-ION CONCENTRATION; INDENES; MAGNESIUM; OUABAIN; OXAZOLES; OXYGEN; POTASSIUM; REFERENCE VALUES; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; UREA;

EID: 0032529097     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.225bi.x     Document Type: Article

References (45)

1. APOVO, M., BEUZARD, Y., GALACTEROS, F., BACHIR, D. & GIRAUD, F. (1994). The involvement of the Ca-dependent K channel and of the KCl cotransport in sickle cell dehydration during cyclic deoxygenation. Biochimica et Biophysica Acta 1225, 255-258.
2. BERKOWITZ, L. R. & ORRINGER, E. P. (1985). Passive sodium and potassium movements in sickle erythrocytes. American Journal of Physiology 249, C208-214.
3. BOOKCHIN, R. M., ORTIZ, O. E. & LEW, V. L. (1991). Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia. Journal of Clinical Investigation 87, 113-124.
4. BORGESE, F., MOTAIS, R. & GARCIA-ROMEU, F. (1991). Regulation of Cl-dependent K transport by oxy-deoxyhemoglobin transitions in trout red cells. Biochimica et Biophysica Acta 1066, 252-256.
5. BRUGNARA, C., BUNN, H. F. & TOSTESON, D. C. (1986). Regulation of erythrocyte cation and water content in sickle cell anemia. Science. 232, 388-390.
6. BRUGNARA, C. & TOSTESON, D. C. (1987). Inhibition of K transport by divalent cations in sickle erythrocytes. Blood 70, 1810-1815.
7. BRUGNARA, C., VAN HA, T. & TOSTESON, D. C. (1989). Acid pH induces formation of dense cells in sickle erythrocytes. Blood 74, 487-495.
8. + fluxes in sheep red cells. Journal of Physiology 506, 679-688.
9. 2+ modulation. Blood 70, 1861-1866.
10. - transport is elevated in oxygenated SS, SC and CC human red cells. FEBS Letters 200, 197-202.
11. COSSINS, A. R., WEAVER, Y. R., LYKKEBOE, G. & NIELSEN, O. B. (1994). Role of protein phosphorylation in control of K flux pathways of trout red blood cells. American Journal of Physiology 267, C1641 1650.
12. CULLIFORD, S. J., ELLORY, J. C., GIBSON, J. S. & SPEAKE, P. F. (1998). Effects of urea and oxygen tension on K flux in sickle cells. Pflügers Archiv 435, 740-742.
13. DUNHAM, P. B. & ELLORY, J. C. (1981). Passive potassium transport in low potassium sheep red cells: dependence upon cell volume and chloride. Journal of Physiology 318, 511-530.
14. EATON, W. A. & HOFRICHTER, J. (1987). Hemoglobin S gelation and sickle cell disease. Blood 70, 1245-1266.
15. ELLORY, J. C., HALL, A. C. & ODY, S. A. (1989a). Is acid a more potent activator of KC1 co-transport than hypotonicity in human red cells? Journal of Physiology 420, 149P.
16. ELLORY, J. C., HALL, A. C., ODY, S. A., DEFIGUEIREDOS, C. E., CHALDER, S. & STUART, J. (1991). KCl cotransport in HbAA and HbSS red cells: activation by intracellular acidity and disappearance during maturation. In Red Blood Cell Ageing, ed. MANGANI, M. & DEFLORA, A., pp. 47-57. Plenum Press, New York.
17. ELLORY, J. C., HALL, A. C., ODY, S. O., ENGLERT, H. C., MANIA, D. & LANG, H.-J. (1990). Selective inhibitors of KCl cotransport in human red cells. FEBS Letters 262, 215-218.
18. ELLORY, J. C., PLAYER, M., CHALDER, S. M. & STUART, J. (1989b). Rheological effect of activation of the KCl-cotransport pathway in normal and sickle erythrocytes. Clinical Hemorheology 9, 1009-1016.
19. 2+ levels of sickle cell anemia red cells. Journal of Clinical Investigation 92, 2489-2498.
20. FABRY, M. E., ROMERO, J. R., BUCHANAN, I. D., SUZUKA, S. M., STAMATOYANNOPOULOS, G., NAGEL, R. L. & CANESSA, M. (1991). Rapid increase in red blood cell density driven by K: Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes. Blood 78, 217-225.
21. FRANCO, R. S., PALASCAK, M., THOMPSON, H., RUCKNAGEL, D. L. & JOINER, C. H. (1996). Dehydration of transferrin receptor-positive sickle reticulocytes during continuous or cyclic deoxygenation: role of KCl cotransport and extracellular calcium. Blood 88, 4359-4365.
22. -]-cotransport system. Molecular Pharmacology 33, 696-701.
23. GARDOS, G. (1958). The function of calcium and potassium permeability of human erythrocytes. Biochimica et Biophysica Acta 30, 653-654.
24. - cotransport in equine red blood cells. Experimental Physiology 79, 997-1009.
25. HALL, A. C. & ELLORY, J. C. (1986). Evidence for the presence of volume-sensitive KCl transport in 'young' human red cells. Biochimica et Biophysica Acta 858, 317-320.
26. HONESS, N. A., GIBSON, J. S. & COSSINS, A. R. (1996). The effects of oxygenation upon the Cl-dependent K flux pathway in equine red cells. Pflügers Archiv 432, 270-277.
27. + transport across the carp red blood cell membrane. Journal of Experimenal Biology 171, 349-371.
28. JOINER, C. H., DEW, A. & GE, D. L. (1988). Deoxygenation-induced fluxes in sickle cells. I. Relationship between net potassium efflux and net sodium influx. Blood Cells 13, 339-348.
29. JOINER, C. H., MORRIS, C. L. & COOPER, E. S. (1993). Deoxygenation-induced cation fluxes in sickle cells. III. Cation selectivity and response to pH and membrane potential. American Journal of Physiology 264, C734-744.
30. KAJI, D. M. & GASSON, C. (1995). Urea activation of K-Cl cotransport in human erythrocytes. American Journal of Physiology 268, C1018-1025.
31. LAUF, P. K. (1985). KCl cotransport: sulfhydryls, divalent cations and the mechanism of volume activation in a red cell. Journal of Membrane Biology 88, 1-13.
32. LAUF, P. K., BAUER, J., ADRAGNA, N. C., FUJISE, H., MARTIN, A., ZADE-OPPEN, M., RYU, K. H. & DELPIRE, E. (1992). Erythrocyte K-Cl cotransport: properties and regulation. American Journal of Physiology 263, C917-932.
33. + sheep. Journal of Cellular Physiology 116, 35-44.
34. LEW, V. L., BALAZS, T. & BOOKCHIN, R. M. (1995). Osmotic effects of water compartments in protein polymers. Cell Biochemistry and Function 13, 173-176.
35. LEW, V. L., FREEMAN, C. J., ORTIZ, O. E. & BOOKCHIN, R. M. (1991). A mathematical model of the volume, pH and ion content regulation in reticulocytes. Journal of Clinical Investigation 87, 100-112.
36. 2+ permeability. Journal of Clinical Investigation 99, 2727-2735.
37. + fluxes in trout red blood cells. American Journal of Physiology 263, C1057-1064.
38. OHNISHI, S. T., HORIUCHI, K. Y. & HORIUCHI, K. (1986). The mechanism of in vitro formation of irreversibly sickled cells and modes of action of its inhibitors. Biochimica et Biophysica Acta 886, 119-129.
39. -) cotransport system in human erythrocytes. Blood 79, 793-797.
40. ORTIZ, O. R., LEW, V. L. & BOOKCHIN, R. M. (1990). Deoxygenation permeabilizes sickle cell anaemia red cells to magnesium and reverses its gradient in the dense cells. Journal of Physiology 427, 211-226.
41. SPEAKE, P. F. & GIBSON, J. S. (1997). Urea-stimulated K-Cl cotransport in equine red blood cells. Pflügers Archiv 434, 104-112.
42. SPEAKE, P. F., ROBERTS, C. A. & GIBSON, J. S. (1997). Effect of changes in respiratory blood parameters on equine red blood cell K-Cl cotransporter. American Journal of Physiology 273, C1811-1818.
43. STARKE, L. C. & JENNINGS, M. L. (1993). K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1. American Journal of Physiology 264, C118-124.
44. TOSTESON, D. C. (1955). The effects of sickling on ion transport. II. The effect of sickling on sodium and cesium transport. Journal of General Physiology 39, 55-67.
45. - cotransport system. Proceedings of the National Academy of Sciences of the USA 86, 4273-4276.