Rapid in vivo induction of leukocyte tissue factor mRNA and protein synthesis following low dose endotoxin administration to rabbits

Hematology Journal

Volumn 2, Issue 3, 2001, Pages 188-195

  Brutzki, T C ^a   Kulczycky, M J ^a   Bardossy, L ^a   Clarke, B J ^a   Blajchman, M A ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Animal model; DIC; Disseminated intravascular coagulation; Endotoxin; Non overt DIC; Tissue factor

Indexed keywords

ENDOTOXIN; FIBRIN; MESSENGER RNA; RETINOIC ACID; THROMBOPLASTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CELL COUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRIN DEPOSITION; GLOMERULUS CAPILLARY; GRAM NEGATIVE INFECTION; HYPOTHESIS; IN VIVO STUDY; LEUKOCYTE; LEUKOCYTE COUNT; MALE; MONONUCLEAR CELL; NONHUMAN; PRIMATE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RABBIT; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA MINNESOTA; THROMBOCYTE COUNT; TIME; TRANSCRIPTION REGULATION; VOLUNTEER;

ANIMALS; ANTITHROMBIN III; BLOOD CELL COUNT; DISSEMINATED INTRAVASCULAR COAGULATION; DRUG EVALUATION, PRECLINICAL; ENDOTOXEMIA; FIBRIN; FIBRINOGEN; GENE EXPRESSION REGULATION; KIDNEY GLOMERULUS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; RABBITS; RNA, MESSENGER; THROMBOCYTOPENIA; THROMBOPLASTIN; TRETINOIN;

EID: 0034930244     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200088     Document Type: Article

References (43)

1. Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis
2. Laboratory models of sepsis and septic shock
3. Animal models of sepsis and shock: A review and lessons learned
4. Molecules and mechanisms operating in septic shock: Lessons from knockout mice
5. Pathogenesis of disseminated intravascular coagulation in sepsis
6. Disseminated intravascular coagulation
7. Recognition of gram-negative bacteria and endotoxin by the immune system
8. Regulation of tissue factor gene expression in human monocytic and endothelial cells
9. Regulation of the tissue factor gene
10. Retinoic acid selectively inhibits lipopolysaccharide induction of tissue factor gene expression in human monocytes
11. Disseminated intravascular coagulation: Clinical and laboratory aspects
12. Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: Effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway inhibitor
13. The clearance, tissue distribution and cellular localization of intravenously injected lipopolysaccharide in rabbits
14. An evaluation of currently available methods for plasma fibrinogen
15. Gerinnungsphysiologische schnellmethode zur bestimmung des fibrinogens
16. New chromogenic ATIII activity kit which is insensitive to heparin cofactor II and designed for use on automated instruments
17. Studies on the character and staining of fibrin
18. The procoagulant state of the VX-2 tumor in vivo: Relative accumulation of fibrinogen, prothrombin, plasminogen, antithrombin and heparin cofactor II within the tumor
19. Molecular cloning, characterization and expression of cDNA for rabbit brain tissue factor
20. Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs
21. Primer-directed enzymatic amplication of DNA with a thermostable DNA polymerase
22. Blood-borne tissue factor: Another view of thrombosis
23. Mechanism of tissue factor activation on cells
24. Neutrophil migration during endotoxemia
25. Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
26. The impact of all-trans retinoic acid on the coagulopathy of acute promyelocytic leukemia
27. Lipopolysaccharide induction of tissue factor expression in rabbits
28. Treatment of disseminated intravascular coagulation (DIC) with all-trans retinoic acid in an endotoxin-induced rat model
29. Dithiocarbamates ameliorate the effects of endotoxin in a rabbit model of disseminated intravascular coagulation
30. New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia: Clinical and basic studies for the next generation
31. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees
32. Complete inhibition of endotoxin-induced coagulation activation in chimpanzees with a monoclonal Fab fragment against factor VII/VIIa
33. 100 Escherichia coli in the baboon
34. Active site inhibited factor VIIa(DEGR VIIa) attenuates the coagulant and interleukin-6 and -8, but not tumor necrosis factor, responses of the baboon to LD100 Escherichia Coli
35. Anti-CD14 monoclonal antibody treatment provides therapeutic benefit after in vivo exposure to endotoxin
36. Endotoxin-induced disseminated intravascular coagulation in rabbits: Effect of recombinant hirudin on hemostatic parameters, fibrin deposits and mortality
37. Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin-induced disseminated intravascular coagulation in rabbits
38. Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator(t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits
39. Combined antithrombin III and C1-esterase inhibitor treatment decreases intravascular fibrin deposition and attenuates cardiorespiratory impairment in rabbits exposed to Escherichia coli endotoxin
40. Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
41. Expression and purification of recombinant rabbit factor VII