Retinoid X receptor expression in skeletal muscle of nondiabetic, obese and type 2 diabetic individuals

Metabolism: Clinical and Experimental

Volumn 50, Issue 7, 2001, Pages 830-834

  Codner, E ^a   Loviscach, M ^a   Ciaraldi, T P ^a   Rehman, N ^a   Carter, L ^a   Mudaliar, S ^a   Henry, R R ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INSULIN; MESSENGER RNA; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOID X RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; GENE CONTROL; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE; WESTERN BLOTTING;

EID: 0034928491     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2001.24929     Document Type: Article

References (36)

1. Orphan nuclear receptors: From gene to function
2. The RXR heterodimers and orphan receptors
3. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
4. Identification, characterization, and tissue distribution of human perixisome proliferator-activated receptor (PPAR) isoforms PPARγ2 versus PPARγ1 and activation with retinoid X receptor agonists and antagonists
5. Central hypothyroidism associated with retinoid X receptor-selective ligands
6. A decade of molecular biology of retinoic acid receptors
7. PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
8. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism
9. Thiazolidinediones in the treatment of insulin resistance and type II diabetes
10. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: Binding and activation correlate with antidiabetic actions in db/db mice
11. The structure-activity relationship between peroxisone proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones
12. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
13. Activation of specific RXR heterodimers by an antagonist of RXR homodimers
14. RXR agonists activate PPARgamma-inducible genes, lower triglycerides, and raise HDL levels in vivo
15. The RXR agonist LG100268 causes hepatomegaly, improves glycemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction
16. Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: A balanced overview
17. Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects
18. Pioglitazone-induced increase of insulin sensitivity in the muscle of the obese Zucker fa/fa rat cannot be explained by local adipocyte differentiation
19. Actions of novel antidiabetic thiazolidinedione, T-174, in animal models of non-insulin-dependent diabetes mellitus and in cultured muscle cells
20. Effect of ciglitazone on glucose uptake and insulin sensitivity in skeletal muscle of the obese (ob/ob) mouse: Distinct insulin and glucocorticoid effects
21. Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle
22. Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
23. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus
24. Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARγ agonist) action
25. Western blotting" electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
26. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
27. PPARgamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects
28. The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signaling
29. PPARgamma, the ultimate thrifty gene
30. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPAR-gamma) heterodimers: Intermolecular synergy requires only the PPAR-gamma hormone-dependent activation function
31. Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes
32. Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L6 myotubes
33. Gene transcription of the retinoid X receptor alpha (RXRα) is regulated by fatty acids and hormones in rat hepatic cells
34. Retinoid X receptor (RXRalpha) gene expression is regulated by fatty acids and dexamethasone in hepatic cells
35. The acute phase response is associated with retinoid X receptor expression in rodent liver
36. Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes