Transgene delivery with a cationic lipid in the presence of amyloid β (βAP) peptide

Neurochemical Research

Volumn 26, Issue 3, 2001, Pages 195-202

  Ajmani, Preeti S ^a   Wang, Wei ^a   Tang, Fuxing ^a   King, Mike A ^a   Meyer, Edwin M ^a   Hughes, Jeffrey A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Alzheimer; Amyloid peptide; Cationic lipid; Gene therapy; Non viral

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [25-35]; AMYLOID BETA PROTEIN [35-25]; LIPID; LIPOSOME; PLASMID DNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ELECTRON MICROSCOPY; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSGENE;

AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; DNA; ENDOCYTOSIS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HUMANS; LIPIDS; MICROSCOPY, ELECTRON; PEPTIDE FRAGMENTS; PLASMIDS; RATS; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0034928303     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010956231321     Document Type: Article

References (24)

1. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
2. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
3. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
4. Alzheimer's disease: Genotypes, phenotypes, and treatments
5. Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
6. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
7. Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity
8. Up and down expression of the dopamine transporter by plasmid DNA transfer in the rat brain
9. Dc-Chol liposome mediated gene transfer in rat spinal cord
10. Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS
11. Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA
12. Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid
13. Chronic ethanol increases N-methyl-p-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons
14. Optimized survival of hippocampus neurons in B27-supplemented neurobasal, a new serum-free medium combination
15. Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures
16. Atomic force microscopy for studying gene transfection mediated by cationic liposomes with a cationic cholesterol derivative
17. A fluorometric assay for the quantification of RNA in solution with nanogram sensitivity
18. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment beta 25-35 requires aggregation and beta-sheet formation
19. Oxidative stress after acute and chronic application of β-amyloid fragment 25-35 in cortical cultures
20. The amyloid β protein induces oxidative damage of mitochondrial DNA
21. Pre-exposure of cells to cationic lipids enhances transgene delivery and expression in a tissue culture cell line
22. Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells
23. Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells
24. Imaging surface and submembranous structures with the atomic force microscope: A study on living cancer cells, fibroblasts and macrophages