Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 10, 1997, Pages 2289-2291

  Nakano, Masahiro ^a   Deguchi, Takashi ^a   Kawamura, Takeshi ^a   Yasuda, Mitsuru ^a   Kimura, Masashi ^a   Okano, Yukio ^a   Kawada, Yukimichi ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA FRAGMENT; DNA TOPOISOMERASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM CULTURE; BACTERIUM ISOLATION; DRUG RESISTANCE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0030840545     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.10.2289     Document Type: Article

References (16)

1. Breines, D. M., S. Ouabdesselam, E. Y. Ng, J. Tankovic, S. Shah, C. J. Soussy, and D. C. Hooper. 1997. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob. Agents Chemother. 41:175-179.
2. Cambau, E., E. Perani, C. Dib, C. Petinon, J. Trias, and V. Jarlier. 1995. Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem. Antimicrob. Agents Chemother. 39:2248-2252.
3. Fukuda, H., M. Hosaka, K. Hirai, and S. Iyobe. 1990. New norfloxacin resistance gene in Pseudomonas aeruginosa PAO. Antimicrob. Agents Chemother. 34:1757-1761.
4. Japan Society of Chemotherapy. 1981. A method for determining the minimum inhibitory concentrations of antimicrobial agents (3rd edition). Chemotherapy (Tokyo) 29:76-79. (In Japanese.)
5. Kato, J., Y. Nishimura, R. Imamura, H. Niki, S. Hiraga, and H. Suzuki. 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63:393-404.
6. Kersulyte, D., M. J. Struelens, A. Deplano, and D. E. Berg. 1995. Comparison of arbitrarily primed PCR and macrorestriction (pulsed-field gel electrophoresis) typing of Pseudomonas aeruginosa strains from cystic fibrosis patients. J. Clin. Microbiol. 33:2216-2219.
7. Kureishi, A., J. M. Diver, B. Beckthold, T. Schollaardt, and L. E. Bryan. 1994. Cloning and nucleotide sequence of Pseudomonas aeruginosa DNA gyrase gyrA gene from strain PAO1 and quinolone-resistant clinical isolates. Antimicrob. Agents Chemother. 38:1944-1952.
8. Lei, Y., K. Sato, and T. Nakae. 1991. Ofloxacin-resistant Pseudomonas aeruginosa mutants with elevated drug extrusion across the inner membrane. Biochem. Biophys. Res. Commun. 178:1043-1048.
9. Li, X.-Z., H. Nikaido, and K. Poole. 1995. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
10. Masuda, N., E. Sakagawa, and S. Ohya. 1995. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:645-649.
11. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:382-388.
12. Peng, H., and K. J. Marians. 1993. Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J. Biol. Chem. 268:24481-24490.
13. Yonezawa, M., M. Takahata, N. Matsubara, Y. Watanabe, and H. Narita. 1995. DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1970-1972.
14. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
15. Yoshida, H., M. Bogaki, M. Nakamura, L. M. Yamanaka, and S. Nakamura. 1991. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob. Agents Chemother. 35:1647-1650.
16. Yoshihara, E., and T. Nakae. 1989. Identification of porins in the outer membrane of Pseudomonas aeruginosa that form small diffusion pores. J. Biol. Chem. 264:6297-6301.