Use of dopamine-β-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 651-657

  Cryan, John F ^a,b   Dalvi, Ashutosh ^a,c   Jin, Sung Ha ^a   Hirsch, Bradford R ^a   Lucki, Irwin ^a   Thomas, Steven A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Department of Psychopharmacology ^*  (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMFEBUTAMONE; AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT; DESIPRAMINE; DOPAMINE BETA MONOOXYGENASE; MONOAMINE OXIDASE INHIBITOR; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; PARGYLINE; REBOXETINE; SODIUM CHLORIDE; THREO 3,4 DIHYDROXYPHENYLSERINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DEPRESSION; DRUG MECHANISM; ENZYME DEFICIENCY; FEMALE; FORCED SWIMMING TEST; GENE DISRUPTION; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; NORADRENALIN RELEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCORING SYSTEM;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BEHAVIOR, ANIMAL; DEPRESSION; DOPAMINE BETA-HYDROXYLASE; MICE; MICE, KNOCKOUT; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NOREPINEPHRINE; SIGNAL TRANSDUCTION; SWIMMING;

EID: 0034913629     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Partial injury to central noradrenergic neurons: Reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis
2. Bupropion: A review of its mechanism of antidepressant activity
3. DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment
4. Does monoamine oxidase inhibition by pargyline increase extracellular dopamine concentrations in the striatum?
5. Is the forced swimming test a suitable model for revealing antidepressant activity?
6. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
7. Monoamine dysfunction and the pathophysiology and treatment of depression
8. Evidence that the acute behavioral and electrophysiological effects of bupropion (Wellbutrin) are mediated by a noradrenergic mechanism
9. Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus
10. Murine models of depression
11. Norepinephrine involvement in antidepressant action
12. Selective effects of DSP-4 on locus coeruleus axons: Are there pharmacologically different types of noradrenergic axons in the central nervous system?
13. Depressions following reserpine: A reevaluation
14. A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: A microdialysis study in vivo
15. Effects of noradrenaline depletion in the brain on response on novelty in isolation-reared rats
16. Recognition sites for norepinephrine uptake: Regulation by neurotransmitter
17. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
18. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice
19. Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine
20. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression
21. Effects of chronic bupropion on interstitial concentrations of dopamine in rat nucleus accumbens and striatum
22. Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
23. Behavioural despair in mice: A primary screening test for antidepressants
24. Dopamine and depression -therapeutic implications
25. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
26. The catecholamine hypothesis of affective disorders: A review of supporting evidence
27. Immunolocalization of the cocaine- and antidepressant-sensitive 1-norepinephrine transporter
28. Effect of monoamine precursors on the forced-swimming test in mice
29. Involvement of the brain catecholaminergic system in the regulation of dominant behavior
30. Noradrenaline release in the locus coeruleus of conscious rats is triggered by drugs, stress and blood pressure changes
31. Central noradrenergic neurones and stress
32. Effect of changes in swimming area on results of behavioral despair test
33. Neurochemical characterization of extracellular serotonin in the rostral ventromedial medulla and its modulation by noxious stimuli
34. Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase
35. Noradrenaline is essential for mouse fetal development
36. Impaired maternal behavior in mice lacking norepinephrine and epinephrine
37. Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory
38. Activation of the locus ceruleus brain noradrenergic system during stress: Circuitry, consequences, and regulation
39. Reboxetine a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor
40. Site-directed mutagenesis of monoamine oxidase A and B: Role of cysteines