A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: A microdialysis study in vivo

Psychopharmacology

Volumn 136, Issue 3, 1998, Pages 299-303

  Hughes, Zoë A ^a   Stanford, S Clare ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Desipramine; DSP 4; In vivo microdialysis; Noradrenaline

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; DESIPRAMINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NERVE INJURY; NEUROTRANSMISSION; NONHUMAN; NORADRENALIN BRAIN LEVEL; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION;

ANIMALS; BENZYLAMINES; BIOGENIC MONOAMINES; CALCIUM; DESIPRAMINE; EXTRACELLULAR SPACE; MALE; MICRODIALYSIS; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE; POTASSIUM; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHECTOMY, CHEMICAL; SYMPATHOMIMETICS;

EID: 0031938020     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050569     Document Type: Article

References (17)

1. Abercrombie ED, Zigmond MJ (1989) Partial injury to central noradrenergic neurones: reduction in norepinephrine content is greater than reduction ot extracellular norepinephrine measured by microdialysis. J Neurosci 9 : 4062-4067
2. 3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 : 63-70
3. Chiodo LA, Acheson AL, Zigmond MJ, Stricker EM (1983) Subtotal destruction of central noradrenergic projections increases the firing rate of locus coeruleus cells. Brain Res 264 : 123-126
4. Dalley JW, Stanford SC (1995) Incremental changes in extracellular noradrenaline availability in the frontal cortex induced by naturalistic environmental stimuli: a microdialysis study in the freely-moving rat. J Neurochem 65 : 2644-2651
5. Fritschy JM, Grzanna R (1989) Immunohistochemical analysis of the neurotoxic effects of DSP-4 identities two populations of noradrenergic axon terminals. Neuroscience 30 : 181-197
6. Fritschy JM, Geffard M, Grzanna R (1990) The response of noradrenergic axons to systemically administered DSP-4 in the rat: an immunohistochemical study using antibodies to noradrenaline and dopamine-β-hydroxylase. J Chem Neuroanat 3 : 309-321
7. Hallman H, Jonsson G (1984) Pharmacological modifications of the neurotoxic action of the noradrenaline neurotoxin DSP-4 on central noradrenaline neurons. Eur J Pharmacol 103 : 269-278
8. Heal DJ, Butler SA, Prow MR, Buckett WR (1993) Quantification of presynaptic α2-adrenoceptors in rat brain after short-term DSP-4 lesioning. Eur J Pharmacol 249 : 37-41
9. Hughes ZA, Stanford SC (1996) Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex. Eur J Pharmacol 317 : 83-90
10. Jonsson G, Hallman H, Ponzio F, Ross S (1981) DSP-4 (N-2(-chloroethyl)-N-ethyl-2-bromobenzylamine) a useful denervation tool for central and peripheral noradrenaline neurons. Eur J Pharmacol 72 : 173-188
11. Kask A, Harro J, Tuomainen P, Rägo L, Männistö PT (1997) Overflow of noradrenaline and dopamine in frontal cortex after [N-2(-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetised rats. Naunyn-Schmiedeberg's Arch Pharmacol 355 : 267-272
12. 3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes. J Neurosci 10 : 1515-1525
13. Logue MP, Growdon JH, Coviella ILG, Wurtman RJ (1985) Differential effects of DSP-4 administration on regional brain norepinephrine turnover in rats. Life Sci 37 : 403-409
14. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, London
15. Ross SB (1976) Long-term effects of N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart. Br J Pharmacol 58 : 521-527
16. Smith SL, Mason K, Stanford SC, Prow MR, Heal DJ (1996) DSP-4 neurotoxicity in rat brain: effect on heat-shock protein expression and in vivo noradrenaline efflux. Br J Pharmacol 117 : 131P
17. Theron CN, de Villiers AS, Taljaard JJF (1993) Effects of DSP-4 on monoamine and monoamine metabolite levels in rat brain at different times after administration. Neurochem Res 18 : 1321-1327