Gene therapy in heart failure

Best Practice and Research: Clinical Anaesthesiology

Volumn 15, Issue 2, 2001, Pages 301-312

  Schmidt, Ulrich ^a   Hajjar, Roger J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis physiology; Calcium metabolism; Cardiac output; Gene targeting; Gene therapy; Gene transfer; Heart failure; Receptors: adrenergic, beta physiology

Indexed keywords

BETA ADRENERGIC RECEPTOR;

ADRENERGIC ACTIVITY; APOPTOSIS; CALCIUM METABOLISM; CALCIUM TRANSPORT; CLINICAL TRIAL; CLONING VECTOR; DISEASE MODEL; EXPERIMENTAL ANIMAL; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HEART FAILURE; HEART OUTPUT; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SAFETY; SARCOPLASMIC RETICULUM;

EID: 0034907776     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1053/bean.2001.0158     Document Type: Article

References (82)

1. Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors
2. A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes
3. Adrenergic and muscarinic receptors in the human heart
4. Beta-adrenergic signal transduction in the failing and hypertrophied myocardium
5. Modulation of adrenergic receptors and G-transduction proteins in failing human ventricular myocardium
6. New insight into the role of enhanced adrenergic receptor-effector coupling in the heart
7. Intracellular calcium related to force development in twitch contraction of mammalian myocardium
8. Calcium pump overexpression and myocardial function. Implications for gene therapy of myocardial failure
9. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure
10. 2+)-ATPase activity and phosphorylation level of phospholamban
11. Length dependence of calcium- and force-transients in normal and failing human myocardium
12. Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure
13. Cellular and molecular aspects of contractile dysfunction in heart failure
14. Molecular mechanism of hypertrophied failing heart - Abnormalities of the diastolic properties and contractility
15. Cross-bridge dynamics in human ventricular myocardium. Regulation of contractility in the failing heart
16. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship
17. [Ca2+]i in human heart failure: A review and discussion of current areas of controversy
18. Calcium handling proteins in the failing human heart
19. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure
20. Relationship of abnormal intracellular calcium mobilisation to myocyte hypertrophy in human ventricular myocardium
21. Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart
22. Myocardial Ca(2+)- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies
23. Calcium signalling in cardiac muscle cells
24. Phospholamban: A prominent regulator of myocardial contractility
25. Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+
26. Frequency dependent force generation correlates with sarcoplasmic calcium ATPase activity in human myocardium
27. Adenoviral gene transfer of phospholamban in isolated rat cardiomyocytes. Rescue effects by concomitant gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase
28. The relative phospholamban and SERCA2 ratio: A critical determinant of myocardial contractility
29. Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes
30. Functional alterations in adult rat myocytes after overexpression of phospholamban with use of adenovirus
31. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
32. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure
33. Animal models of human cardiovascular disease, heart failure and hypertrophy
34. Human SERCA2a levels correlate inversely with age in senescent human myocardium
35. Aging, changes in the cardiovascular system, and responses to stress
36. The calcium uptake of the rat heart sarcoplasmic reticulum is altered by dietary lipid
37. Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase
38. Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility
39. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
40. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases
41. Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy
42. Calcineurin inhibitors and cardiac hypertrophy
43. Calcineurin and human heart failure
44. Molecular aspects of adrenergic signal transduction in cardiac failure
45. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
46. Expression of a beta-adrenergic receptor kinase I inhibitor prevents the development of myocardial failure in gene-targeted mice
47. Adrenergic effects on the biology of the adult mammalian cardiocyte
48. Inotropic therapy for heart failure
49. beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis
50. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat
51. Abnormalities of cardiocytes in regions bordering fibrous scars of dogs with heart failure
52. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure
53. Apoptosis in myocytes in end-stage heart failure
54. Apoptosis in the failing heart
55. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of capase-3 in human cardiomyopathy
56. Apoptosis in the failing human heart
57. Loss of a gp 130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
58. Apoptosis and heart failure
59. The bcl-2 gene product prevents programmed cell death of ventricular myocytes
60. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion
61. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
62. Regulation of neuronal survival by the serine-threonine protein kinase Akt
63. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
64. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
65. Future perspectives and potential implications of cardiac myocyte apoptosis
66. Prospects for gene therapy for heart failure
67. Efficient gene transfer into myocardium by direct injection of adenovirus vectors
68. A simplified system for generating recombinant adenoviruses
69. Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus
70. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo
71. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus
72. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors
73. Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins
74. Gene delivery to the myocardium by intrapericardial injection
75. Ultrarapid, highly efficient viral gene transfer to the heart
76. Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin
77. Modulation of ventricular function through gene transfer in vivo
78. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene therapy
79. The role of percutaneous aortic balloon valvuloplasty in patients with cardiogenic shock and critical aortic stenosis
80. Clinical and hemodynamic follow-up after percutaneous aortic valvuloplasty in the elderly