Shortcoming in the diagnosis of TPMT deficiency in a patient with Crohn's disease using phenotyping only [1]

Gastroenterology

Volumn 121, Issue 2, 2001, Pages 500-501

  Schwab, M ^a   Schaeffeler, E ^a   Marx, C ^a   Zanger, U ^a   Aulitzky, W ^a   Eichelbaum, M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; THIOPURINE METHYLTRANSFERASE;

ADULT; BONE MARROW SUPPRESSION; CASE REPORT; CLINICAL FEATURE; CROHN DISEASE; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; DRUG EFFECT; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LETTER; PHENOTYPE; PRIORITY JOURNAL; SYMPTOM; THROMBOCYTOPENIA;

EID: 0034899337     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.26927     Document Type: Article

References (11)

1. Azathioprine: State of the art in inflammatory bowel disease
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3. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
4. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
5. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
6. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
7. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
8. Pharmacogenomics: The promise of personalized medicine
9. Thiopurine S-methyltransferase activity in human erythrocytes: A new HPLC method using 6-thioguanine as substrate
10. Pharmacogenomics: Translating functional genomics into rational therapeutics
11. Molecular diagnosis of thiopurine S. methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance