Differential expression of BCL-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T/null-cell lineage

American Journal of Pathology

Volumn 159, Issue 2, 2001, Pages 527-535

  Rassidakis, George Z ^a   Sarris, Andreas H ^a   Herling, Marco ^a   Ford, Richard J ^a   Cabanillas, Fernando ^a   McDonnell, Timothy J ^a   Medeiros, L Jeffrey ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BCL XL; PROTEIN BCL XS; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL LINEAGE; CHILD; FEMALE; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MALE; NICK END LABELING; NULL CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; T CELL LYMPHOMA;

EID: 0034889554     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61724-5     Document Type: Article

References (50)

1. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
2. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells
3. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
4. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
5. Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas
6. Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction
7. High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining
8. Amplification of genomic DNA demonstrates the presence of the t(2;5)(p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis
9. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1
10. The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements
11. A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation
12. TPK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations
13. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis
14. Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 Cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)
15. ALK+ lymphoma: Clinico-pathological findings and outcome
16. Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: A distinct clinicopathologic entity
17. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma
18. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
19. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
20. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
21. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
22. BCL-2 gene family and the regulation of programmed cell death
23. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
24. Bcl-x(S) antagonizes the protective effects of Bcl-x(L)
25. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
26. Bcl-XL and Bcl-2 repress a common pathway of cell death
27. The Bcl-2 protein family: Arbiters of cell survival
28. Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: An analysis of 83 cases
29. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma
30. Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: A population-based study
31. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma
32. Prognostic significance of Bax protein expression in diffuse aggressive non-Hodgkin's lymphoma
33. Bcl-2, Bcl-X, Bax, and Bak expression in short- and long-lived patients with diffuse large B-cell lymphomas
34. Quantitative analysis detects ubiquitous expression of apoptotic regulators in B cell non-Hodgkin's lymphomas
35. Immunodetection of apoptosis-regulating proteins in lymphomas from patients with and without human immunodeficiency virus infection
36. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues
37. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
38. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections
39. The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo
40. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
41. Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
42. Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
43. Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms
44. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: Contribution of CD40 signaling in promoting survival
45. Expression and function of CD95 (FAS/APO-1) in leukaemia-lymphoma tumour lines
46. Detection of differentially expressed genes in lymphomas using cDNA arrays: Identification of clusterin as a new diagnostic marker for analplastic large-cell lymphomas
47. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells
48. Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death
49. Apoptosis induced by the myelodysplastic syndrome-associated NPM-MLF1 chimeric protein
50. Anaplastic large-cell lymphomas of B-cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B-cell lymphomas