The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements

American Journal of Pathology

Volumn 151, Issue 2, 1997, Pages 343-351

  Pittaluga, Stefania ^a   Wlodarska, Iwona ^a   Pulford, Karen ^b   Campo, Elias ^c   Morris, Stephan W ^d   Van den Berghe, Herman ^a   De Wolf Peeters, Chris ^a,e  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c HOSPITAL CLÍNIC   (Spain)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e Department of Pathology II ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY ALK 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; B CELL LYMPHOMA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPHOMATOID PAPULOSIS; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; T CELL LYMPHOMA;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; CHILD; CHROMOSOMES, HUMAN, PAIR 2; CHROMOSOMES, HUMAN, PAIR 5; FEMALE; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, LARGE-CELL; MALE; MIDDLE AGED; PROTEIN-TYROSINE KINASES; TRANSLOCATION, GENETIC;

EID: 0030877702     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Stein H, Dallenbach F: Neoplastic Hematopathology, Edited by D Knowles, Baltimore, Williams & Wilkins, 1992, pp 698-708
2. Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 1985, 66:848-858
3. Agnarsson BA, Kadin ME: Ki-1 positive large cell lymphoma: a morphologic and immunologic study of 19 cases. Am J Surg Pathol 1988, 12:264-274
4. Chott A, Kaserer K, Augustin I, Vesely M, Heinz R, Oehlinger W, Hanak H, Radaszkiewicz T: Ki-1-positive large cell lymphoma: a clinicopathologic study of 41 cases, Am J Surg Pathol 1990, 14:439-448
5. + with a high content of reactive histiocytes), Histopathology 1990, 16:383-391
6. Rosso R, Paulli M, Magrini U, Kindl S, Boveri E, Volpato G, Poggi S, Baglioni P, Pileri S: Anaplastic large cell lymphoma, CD30/Ki-1 positive, expressing the CD15/LeuM1 antigen. Virchows Arch A Pathol Anat Histopathol 1990, 416:229-235
7. Leoncini L, Del Vecchio MT, Kraft R, MeghaT, Barbini P, Cevenini G, Poggi S, Pileri S, Tosi P, Cottier H: Hodgkin's disease and CD30-positive anaplastic large cell lymphomas-a continuous spectrum of malignant disorders, Am J Pathol 1990, 137:1047-1057
8. Kinney MC, Collins RD, Greer JP, Whitlock JA, Sioutos N, Kadin ME: A small-cell-predominant variant of primary Ki-1 (CD30+) T-cell lymphoma. Am J Surg Pathol 1993, 17:859-868
9. Mason DY, Bastard C, Rimokh R, Dastegue N, Huret JL, Kristofferson U, Magaud JP, Nezelof C, Tilly H, Vannier JP, Hemet J, Warnke R: CD30-positive large cell lymphomas ('KM' lymphoma) are associated with a chromosomal translocation involving 5q35, Br J Haematol 1990, 74:161-168
10. Delsol G, AI Saati T, Gatter KG, Gerdes J. Schwarting R, Caveriviere P, Rigal-Huguet F, Robert A, Stein H, Mason DY Coexpression of : epithelial membrane antigen (EMA), KM, lnterleukin-2 receptor by anaplastic large cell lymphomas, Am J Pathol 1988, 130:59-70
11. Harris ML, Jaffe ES, Stein H, Banks PM, Chan JCK, deary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KG, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Müller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group, Blood 1994, 84:1361-1392
12. Morris SW, Kirstein MN, Vanlentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994, 263: 1281-1284
13. + anaplastic large cell lymphomas, in other Non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease. Blood 1995, 86:2321-2328
14. Ebrahim SAD, Ladanyi M, Desai SB, Offit K, Jhanwar SC, Filippa DA, Lieberman PH, Chaganti RSK: Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral T-cell lymphomas of uncertain lineage, including 12 Ki-1 positive lymphomas. Genes Chromosomes Cancer 1990, 2:27-35
15. Lamant L, Meggetto F, AI Saati T, Brugières L, Bressac de Paillerets B, Dastugue N, Bernheim A, Rubie H, Terrier-Lacombe MJ, Robert A, Brousset P, Rigal F, Schlaifer D, Shiota M, Mori S, Delsol G: High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease: comparison of cytogenetic analysis, reverse transcriptase polymerase chain reaction, and p-80 immunostaining. Blood 1996, 87:284-291
16. + lymphomas from American and Asian patients: a reverse transcriptase-polymerase chain reaction study, Am J Pathol 1995, 146:323-328
17. + lymphoproliferative disorders: comparison with anaplastic large cell lymphoma of nodal origin. Blood 1996, 87:3437-3441
18. Elmberger PG, Lozano MD, Weisenburger DD, Sanger W, Chan WC: Transcripts of the NPM-ALK fusion gene in anaplastic large cell lymphoma, Hodgkin's disease, and reactive lymphoid lesions, Blood 1995, 86:3517-3521
19. Downing JR, Shurtleff SA, Zielenska M, Curcio-Brint AM, Behm FG, Head DR, Sandlund JT, Weisenburger DD, Kossakowska AE, Thorner P, Lorenzana A, Ladanyi M, Morris SW: Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood 1995, 85:3416-3422
20. Arber DA, Sun LH, Weiss LM: Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma. Hum Pathol 1996, 27:590-594
21. Weisenburger DD, Gordon BG, Vose JM, Bast MA, Chan WC, Greiner TC, Anderson JR, Sanger WG: Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma. Blood 1996, 87:3860-3868
22. Herbst H, Anagnostopoulos J, Heinze B, Dürkop H, Hummel M, Stein H: ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease. Blood 1995, 86:1694-1700
23. Kaneko Y, Frizzera G, Edamura S, Maseki N, Sakurai M, Komada Y, Sakurai M, Tanaka H, Sasaki M, Suchi T, Kikuta A, Wakasa H, Hojo H, Mizutani S: A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis. Blood 1989, 73:806-813
24. De Bruin PC, Beljaards RC, Van Heerde P, Van Der Valk P, Noorduyns LA, Van Krieken JHJM, Kluin-Nelemans JC, Willemze R, Meijer CJLM: Differences in clinical behaviour and immunophenotype between primary cutaneous and primary nodal anaplastic large cell lymphoma of T-cell or null cell phenotype. Histopathology 1993, 23:127-135
25. Paulli M, Berti E, Rosso R, Boveri E, Kindl S, Klersy C, Lazzarino M, Borroni G, Menestrina F, Santucci M, Gambini C, Vassallo G, Magrini U, Sterry W, Burg G, Geerts ML, Meijer CJLM, Willemze R, Feller AC, Müller-Hermelink HK, Kadin ME: CD30/Ki-1-positive lymphoproliferative disorders of the skin-clinicopathologic correlation, and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project group. J Clin Oncol 1995, 13:1343-1354
26. Beljaards RC, Kaudewitz P, Berti E, Gianotti R, Neumann C, Rosso R, Paulli M, Meijer CJLM, Willemze R: Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. Cancer 1993, 71:2097-2104
27. Shiota M, Nakamura S, Ichinoshama R, Abe M, Akagi T, Takeshita M, Mori N, Fujimoto J, Miyauchi J, Mikata A, Nanba K, Takami T, Yamabe H, Takano Y, Izumo T, Mohri N, Nasu K, Satoh H, Katano H, Fujimoto J, Yamamoto T, Mori S: Anaplastic arge cell lymphomas expressing the novel chimeric protein p80 NPM/ALK: a distinct clinicopathologic entity. Blood 1995, 86:1954-1960
28. + large-cell non-Hodgkin's lymphoma. J Clin Oncol 1994, 12:895-898
29. Yee HT, Ponzonl M, Merson A, Goldstein M, Scarpa A, Chilosi M, Menestrina F, Pittaluga S, De Wolf-Peeters C, Shiota M, Mori S, Frizzera G, Inghirami G: Molecular characterization of the t(2;5)(p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. Blood 1996, 87:1081-1088
30. Orscheschek K, Merz H, Hell J, Binder T, Bartels H, Feller AC: Large-cell anaplastic lymphoma-specific translocation t(2;5)(p23; q35) in Hodgkin's disease: indication of a common pathogenesis? Lancet 1995, 345:87-90
31. Ladanyi M, Cavalchire G, Morris SW, Downing J, Filippa DA: Reverse transcriptase polymerase chain reaction for the Ki-1 anaplastic large cell lymphoma-associated t(2;5) translocation in Hodgkin's disease, Am J Pathol 1994, 145:1296-1300
32. Weiss LM, Lopategui JR, Sun LH, Kamel OW, Koo CH, Glackin C: Absence of the t(2;5) in Hodgkin's disease. Blood 1995, 85:2845-2847
33. Sarris AH, Luthra R, Papadimitracopoulou V, Waasdorp M, Dimopoulos MA, McBride JA, Cabanillas F, Duvic M, Deisseroth A, Morris SW, Pugh WC: Amplification of genomic DNA demonstrates the presence of the t(2;5)(p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis, Blood 1996, 88:1771-1779
34. Shiota M, Fuijmoto J, Takenaga M, Satoh H, Ichinoshama R, Abe M, Nakano M, Yamamoto T, Mori S: Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry. Blood 1994, 84: 3648-3652
35. Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, Delsol G, Mason DY: Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 1997, 89:1394-1404
36. Mitelman F, (Ed): ISCN Guidelines for Cancer Cytogenetics: Supplement to an International System for Human Cytogenetic Nomenclature, Basel, Karger, 1995
37. Mathew P, Sanger WG, Weisenburger DO, Valentine M, Valentine V, Pickering D, Higgins C, Hess M, Cui X, Srivastava DK. Morris SW: Detection of the t(2;5)(p23;q35) and NPM/ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization. Blood 1997, 89:1678-1685
38. National Institutes of Health and Institute of Molecular Medicine Collaboration: A complete set of human telomeric probes and their clinical application, Nat Genet 1996, 14:86-89
39. Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor B to a novel ETS-like gene, TEL, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994, 77:307-316
40. Smith CA, Gruss HJ, Davis T, Anderson D, Farrah T, Baker E, Sutherland GR, Brannan CI, Copeland NG, Jenkins NA, Grabstein KH, Gliniak B, McAlister IB, Fanslow W, Alderson M, Falk B, Gimpel S, Gillis S, Din WS, Goodwln RG, Armitage RJ: CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 1993, 73: 1349-1360
41. Falinl B, Pileri S, Pizzolo G, Dürkop H, Flenghi L, Stirpe F, Martelli MF, Stein H: CD30 (Ki-1 ) molecule: a new cytokine receptor for the tumor necrosis factor receptor superfamily as a tool for diagnosis and immnunotherapy. Blood 1995, 85:1-14
42. Pallesen G, Hamilton-Dutoit SJ: Ki-1 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma. Am J Pathol 1988, 133:446-450
43. Wlodarska I, De Wolf Peeters C, Michaux L, Mecucci C, Verhoef G, Cassiman JJ, Van den Berghe H: A new t(2;5) translocation in a null cell type CD30 positive anaplastic large cell lymphoma case. Leukemia 1995, 9:1685-1688
44. Hagemeijer A, Buijs A, Smit E, Janssens B, Creemers GJ, Van der Plas D, Grosveld G: Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative BCR-positive patients with chronic myeloid leukemia. Genes Chromosomes Cancer 1993, 8:237-245
45. Sainati L, Montaldi A, Stella M, Putti MC, Zanesco L, Basso G: A novel variant translocation t(2;13)(p23;q34) in Ki-1 large cell anaplastic lymphoma. Br J Haematol 1990, 75:621-622
46. Frizzera G: The distinction of Hodgkin's disease from anaplastic large cell lymphoma, Semin Diagn Pathol 1992, 9:291-296