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Volumn 329, Issue 12, 1996, Pages 524-528

On the concept of a bivalent pharmacophore for SKCa channel blockers: Synthesis, pharmacological testing, and radioligand binding studies on mono-, bis-, and tris-quinolinium compounds

(4) Galanakis, Dimitrios a,b Ganellin, Robin C a Dunn, Philip M a Jenkinson, Donald H a

a UNIVERSITY COLLEGE LONDON (United Kingdom)

b ARISTOTLE UNIVERSITY OF THESSALONIKI (Greece)

Author keywords

Apamin; Binding site; Bivalent pharmacophore; Channels; Dequalinium; K+

Indexed keywords

1,1' [5 [4 (4 AMINOQUINOLINIUM 1 YL)BUTYL]NON 4 EN 1,9 DIYL]BIS(4 AMINOQUINOLINIUM) TETRATRIFLUOROACETATE; APAMIN; DEQUALINIUM; POTASSIUM CHANNEL; QUATERNARY AMMONIUM DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL CULTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; ENTROPY; GANGLION; IN VITRO STUDY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DRUG CARRIERS; NEURONS; PROTEIN BINDING; QUINOLINIUM COMPOUNDS; RADIOLIGAND ASSAY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030480435 PISSN: 03656233 EISSN: None Source Type: Journal
DOI: 10.1002/ardp.19963291203 Document Type: Article

Times cited : (16)

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