Molecular analysis of alterations of the p18(INK4c) gene in human meningiomas

Neuropathology and Applied Neurobiology

Volumn 26, Issue 1, 2000, Pages 67-75

  Santarius, T ^a,b   Kirsch, M ^a,c   Nikas, D C ^a   Imitola, J ^a   Black, P M ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Immunohistochemistry; Loss of heterozygosity; Meningioma; Mutation; p18; Tumour suppressor gene

Indexed keywords

DNA; DNA MARKER; GUANINE; MICROSATELLITE DNA; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR; THYMINE;

ADULT; AGED; ARTICLE; CHROMOSOME 1P; CHROMOSOME 22Q; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; EXON; FEMALE; GENE DELETION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE STRUCTURE; HETEROZYGOSITY LOSS; HOMOZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MENINGIOMA; MISSENSE MUTATION; MOLECULAR GENETICS; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P18; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA, SATELLITE; ENZYME INHIBITORS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0034013681     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2000.00219.x     Document Type: Article

References (28)

1. 1 Bello MJ, de Campos JM, Kusak ME et al. Allelic loss at 1p is associated with tumor progression of meningiomas. Genes Chromosomes Cancer 1994; 9: 296-8
2. 2 Blais A, Labrie Y, Pouliot F et al. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. Biochem Biophys Res Commun 1998; 247: 146-53
3. 3 Guan KL, Jenkins CW, Li Y et al. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 1994; 8: 2939-52
4. 4 Hellsten E, Vesa J, Heiskanen M et al. Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus. Genomics 1995; 25: 404-12
5. 5 Hudson TJ, Stein LD, Gerety SS et al. An STS-based map of the human genome. Science 1995; 270: 1945-54
6. 6 Iolascon A, Faienza MF, Coppola B et al. Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma. Genes Chromosomes Cancer 1996; 15: 217-22
7. 7 Jimenez-Lara AM, Rey JA, Bello MJ et al. Cytogenetics of human meningioma: an analysis of 125 cases. Cancer Genet Cytogenet 1992; 63: 174
8. 8 Kamb A, Gruis NA, Weaver-Feldhaus J et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436-40
9. 9 Kawamata N, Seriu T, Koeffler HP et al. Molecular analysis of the cyclin-dependent kinase inhibitor family: p16 (CDKN2/MTS1/INK4A), p18 (INK4C) and p27 (Kip1) genes in neuroblastomas. Cancer 1996; 77: 570-5
10. 10 Kleihues P, Burger PC, Scheithauer BW. Histological Typing of Tumors of the Central Nervous System. New York: Springer-Verlag, 1993
11. 11 Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 68: 820-3
12. 12 Kraus JA, Koopmann J, Kaskel P et al. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropath Exp Neurol 1995; 54: 91-5
13. 13 Lapointe J, Lachance Y, Labrie Y et al. A p18 mutant defective in CDK6 binding in human breast cancer cells. Cancer Res 1996; 56: 4586-9
14. 14 Longstreth WT Jr, Dennis LK, McGuire VM et al. Epidemiology of intracranial meningioma. Cancer 1993; 72: 639-48
15. 15 Lopez-Gines C, Cerda-Nicolas M, Peydro-Olaya A et al. Case of meningioma with del (1) (p32) as sole anomaly. Cancer Genet Cytogenet 1993; 70: 74-6
16. 16 Merlo A, Herman JG. Mao L et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Med) 1995; 1: 686-92
17. 17 Miller CW, Aslo A, Campbell MJ et al. Alterations of the p15, p16,and p18 genes in osteosarcoma. Cancer Genet Cytogenet 1996; 86: 136-42
18. 18 Nobori T, Miura K, Wu DJ et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753-6
19. 19 Reifenberger J, Reifenberger G, Liu L et al. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol 1994; 145: 1175-90
20. 20 Rusin MR, Okamoto A, Chorazy M et al. Intragenic mutations of the p16 (INK4), p15 (INK4B) and p18 genes in primary non-small-cell lung cancers, Int J Cancer 1996; 65: 734-9
21. 21 Ruttledge MH, Xie YG, Han FY et al. Deletions on chromosome 22 in sporadic meningioma. Genes Chromosomes Cancer 1994; 10: 122-30
22. 22 Seizinger BR, Klinger HP, Junien C et al. Report of the committee on chromosome and gene loss in human neoplasia. Cytogenet Cell Genet 1991; 58: 1080-90
23. 23 Smith DB, Davidson F, Yap P et al. Levels of hepatitis C virus in blood donors infected with different viral genotypes. International HCV Collaborative Study Group. J Infect Dis 1996; 173: 727-30
24. 24 Sulman EP, Dumanski JP, White PS et al. Identification of a consistent region of allelic loss on 1p32 in meningiomas: correlation with increased morbidity. Cancer Res 1998; 58: 3226-30
25. 25 Vogelstein B, Fearon ER, Kern SE et al. Allelotype of colorectal carcinomas. Science 1989; 244: 207-11
26. 26 Wellenreuther R, Kraus JA, Lenartz D et al. Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. Am J Pathol 1995; 146: 827-32
27. 27 Yang-Feng TL, Han H, Chen KC et al. Allelic loss in ovarian cancer. Int J Cancer 1993; 54: 546-51
28. 28 Zhu J, Guo SZ, Beggs AH et al. Microsatellite instability analysis of primary human brain tumors. Oncogene 1996; 12: 1417-23