Reliability of experimental models of iodinated contrast media-induced acute renal failure: From methodological considerations to pathophysiology

Investigative Radiology

Volumn 31, Issue 4, 1996, Pages 230-241

  Idée, Jean Marc ^a   Bonnemain, Bruno ^a  

^a Laboratoire Guerbet   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CREATININE; DIATRIZOATE; INULIN; IODINATED CONTRAST MEDIUM; IOHEXOL; IOPAMIDOL; IOTALAMIC ACID; IOXAGLIC ACID; METRIZOIC ACID;

ACUTE KIDNEY FAILURE; ANIMAL MODEL; CREATININE CLEARANCE; ENZYMURIA; GLOMERULUS FILTRATION RATE; INULIN CLEARANCE; ISOLATED KIDNEY; KIDNEY TUBULE NECROSIS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RELIABILITY; REVIEW; UREA NITROGEN BLOOD LEVEL;

EID: 0029988332     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199604000-00008     Document Type: Review

References (96)

1. Idée JM, Beaufils H, Bonnemain B. Iodinated contrast media-induced nephropathy: Pathophysiology, clinical aspects, and prevention. Fundam Clin Pharmacol 1994;8:193-206.
2. Brezis M, Rosen S, Epstein FH. Acute renal failure. In: Brenner BM, Rector FC, eds. The kidney. Philadelphia, PA: WB Saunders Co., 1991:993-1061.
3. Rose BR. Acute renal failure. Prerenal disease versus acute tubular necrosis. In: Rose BR, ed. Pathophysiology of renal disease. New York, NY: McGraw Hill, 1987:63-117.
4. Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Nephrotoxic risks of renal angiography: Contrast media-associated nephrotoxicity and atheroembolism. A critical review. Am J Kidney Dis 1994;24:713-727.
5. Porter GA. Experimental contrast-associated nephropathy and its clinical implications Am J Cardiol 1990;66(suppl):18F-22F.
6. Becker JA. Evaluation of renal function. Radiology 1991;179: 337-338.
7. Gral T, Young M. Measured versus estimated creatinine clearance in the elderly as an index of renal function. J Am Ger Soc 1980;28:492-496.
8. Kassirer JP. Clinical evaluation of kidney function: Glomerular function. New Engl J Med 1971;285:385-389.
9. Levey AS, Madaio MP, Perrone RD. Laboratory assessment of renal disease: Clearance, urinalysis, and renal biopsy. In: Brenner BM. Rector FC, eds. The kidney. Philadelphia. PA: WB Saunders Co., 1991:206-244.
10. Rose BD. Clinical assessment of renal function. In: Rose BD, ed. Pathophysiology of renal disease. New York, NY: McGraw Hill, 1987:1-39.
11. Heyman SN, Brezis M, Greenfeld Z, Rosen S. Protective role of furosemide and saline in radiocontrast-induced acute renal failure in the rat. Am J Kidney Dis 1989;14:377-385.
12. Ducharme MP, Smythe M, Strohs G. Drug-induced alterations in serum creatinine concentrations. Ann Pharmacother 1993;27: 622-633.
13. Katzberg RW, Pabico RC, Morris TW, et al. A comparison of clearance and arteriovenous extraction techniques for measurements of renal hemodynamic function. Invest Radiol 1986;21: 910-916.
14. Idée JM. Evaluation of glomerular filtration rate in the dog after injection of contrast agents. Cath Cardiovasc Diagn 1994;32:301-302. Letter.
15. Rosen S, Solez K. Controversies in acute renal failure. Presented at the XIIIth International Congress of Nephrology; July 2-6, 1995; Madrid, Spain. Abstract.
16. Gruskin AB, Oetliker OH, Wolfish NM, Gootman NL, Bernstein J, Edelmann Jr CM. Effects of angiography on renal function and histology in infants and piglets. J Pediatr 1970;76:41-48.
17. Beaufils H, Idée JM, Berthommier C, et al. Iobitridol, a new nonionic low-osmolality contrast agent, and iohexol: Impact on renal histology in the rat. Invest Radiol 1995;30:33-39.
18. Deray G, Dubois M, Martinez F, et al. Renal effects of radiocontrast agents in rats: A new model of acute renal failure. Am J Nephrol 1990;10:507-513.
19. Agmon Y, Peleg H, Greenfeld Z, Rosen S, Brezis M. Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat. J Clin Invest 1994;94:1069-1075.
20. Rosen S, Brezis M, Stillman I. The pathology of nephrotoxic injury: A reappraisal. Miner Electrolyte Metab 1994;20:174-180.
21. Le Hir M, Dubach UC. Distribution of acid hydrolases in the nephron of normal and diabetic rats. Int J Biochem 1980;12:41-45.
22. Bourbouze R, Baumann FC, Bonvallet JP, Farman N. Distribution of N-acetyl-beta-D-glucosaminidase isoenzymes along the rabbit nephron. Kidney Int 1984;25:636-642.
23. Jung K. Urinary enzyme and low molecular weight proteins as markers of tubular dysfunction. Kidney Int 1994;46(suppl): S29-S33.
24. Mutti A. Detection of renal diseases in humans: Developing markers and methods. Toxicol Lett 1989;46:177-191.
25. Fillastre JP, Baud L, Baumelou A, et al. Détection de la néphrotoxicité médicamenteuse. J Pharmacol (Paris) 1986;17(suppl 1): 41-50.
26. Grötsch H, Hropot M, Klaus E, Wesely J. Influences of seasonal biorhythms on urinary excretion of enzymes and other parameters. J Clin Chem Clin Biochem 1990;28:285-286.
27. Fuchs E, Grötsch H. Animal models. In: Jung K, Mattenheimer H, Burchardt U, eds. Urinary enzymes in clinical and experimental medicine. New York, NY: Springer Verlag, 1992;247-252.
28. Grötsch H, Hropot M, Klaus E, Malerczyk V, Mattenheimer H. Enzymuria of the rat: Biorhythms and sex differences. J Clin Chem Clin Biochem 1985;23:343-347.
29. Nakamura M, Itoh T, Miyata K, Higashima N, Takesue H, Nishiyama S. Difference in urinary N-acetyl-beta-D-glucosaminidase activity between male and female beagle dogs. Renal Physiol 1983;6:130-133.
30. Powell CJ, Dobrota M, Holtz E. Studies on the mechanism of radiological contrast media-induced renal failure. In: Bach PH, Lock EA, eds. Nephrotoxicity: In vitro to in vivo: Animal to man. New York. NY: Plenum Press, 1989;463-468.
31. Thomsen HS, Skaarup P, Larsen S, Golman K, Hemmingsen L. Gentamicin nephropathy and contrast media. A comparison between diatrizoate and iohexol in rats. Acta Radiol 1990;31: 401-407.
32. Krakenes J, Elsayed S, Göthlin J, Farstad M. Proteinuria after selective nephroangiography in man: Comparison of three contrast media. Acta Radiol 1980;21:401-406.
33. Porter GA. Urinary biomarkers and nephrotoxicity. Miner Electrolyte Metab 1994;20:181-186.
34. Cantley LG, Spokes K, Clark B, McMahon EG, Carter J, Epstein FH. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney Int 1993;44:1217-1223.
35. Brown PWG, Haylor JL, El Nahas AM, Morcos SK. The functional effects of contrast media on the isolated perfused rat kidney. In: Bianchi C, Bocci V, Carone FA, Rabkin R, eds. Kidney, proteins, and drugs: An update. Contrib Nephrol 1993;101: 235-240.
36. Idée JM, Santus R, Beaufils H, et al. Comparative effects of low-and high-osmolar contrast media on the renal function during early degenerative gentamicin-induced nephropathy in rats. Am J Nephrol 1995;15:66-74.
37. Andersen KJ, Christensen El, Vik H. Effects of iodinated X-ray contrast media on renal epithelial cells in culture. Invest Radiol 1994;29:955-962.
38. Margulies KB, McKinley LJ, Cavero PG, Burnett JC. Induction and prevention of radiocontrast-induced nephropathy in dogs with heart failure. Kidney Int 1990;38:1101-1108.
39. Bakris GL, Burnett Jr JC. A role for calcium in radiocontrast-induced reductions in renal hemodynamics. Kidney Int 1985;27: 465-468.
40. Brezis M. Forefronts in nephrology: Summary of the newer aspects of renal cell injury. Kidney Int 1992;42:523-539.
41. Barrett BJ, Carlisle EJ. Metaanalysisof the relative nephrotoxicity of high- and low-osmolality iodinated contrast media. Radiology 1993;188:171-178.
42. Rudnick MR, Goldfarb S, Wexler L, et al, for the Iohexol Cooperative Study. Nephrotoxicity of ionic and nonionic contrast media in 1196 patients: A randomized trial. Kidney Int 1995;47: 254-261.
43. Deray G, Baumelou B, Martinez F, Brillet G, Jacobs C. Renal vasoconstriction after low and high osmolar contrast agents in ischemic and non ischemic canine kidney. Clin Nephrol 1991;36:93-96.
44. Tornquist C, Almén T, Golman K, Holtas S. Renal function following nephroangiography with metrizamide and iohexol: Effects on renal blood flow, glomerular permeability, and filtration rate and diuresis in dogs. Acta Radiol 1985;26:483-489.
45. Brezis M, Greenfeld Z, Herman M, Meyer JJ, Heyman SN, Rosen S. Experimental nephrotoxicity of the radiocontrast agents iohexol, ioxaglate, and iothalamate: An in vitro and in vivo study. Invest Radiol 1991;26:325-331.
46. Yoshioka T, Fogo A, Beckman JK. Reduced activity of antioxidant enzymes underlies contrast media-renal injury in volume depletion. Kidney Int 1992;41:1008-1015.
47. Messana JH, Cieslinski DA, Nguyen VD, Humes HD. Comparison of the toxicity of the radiocontrast agents, iopamidol and diatrizoate, to rabbit renal proximal tubule cells, in vitro. J Pharm Exp Ther 1988;244:1139-1144.
48. De Bono GG. Osmolality and ionicity: Confusion in terminology applied to contrast media. Radiology 1988;168:281.
49. Harvey AM, Malvin RL. Comparison of creatinine and inulin clearances in male and female rats. Am J Physiol 1965;209:849-852.
50. Harvey AM, Malvin RL. The effect of androgenic hormones on creatinine secretion in the rat. J Physiol 1966;184:883-888.
51. Munger K, Baylis C. Sex differences in renal hemodynamics in rats. Am J Physiol 1988;254:F223-F231.
52. Pons M, Tranchot J, L'Azou B, Cambar J. Circadian rhythms of renal hemodynamics in unanesthetized, unrestrained rats. Chronobiol Int 1994;5:301-308.
53. Heyman SN, Brezis M, Reubinoff CA, et al. Acute renal failure with selective medullary injury in the rat. J Clin Invest 1988;82: 401-412.
54. Lear S, Silva P, Kelley VE, Epstein FH. Prostaglandin E2 inhibits oxygen consumption in rabbit medullary thick ascending limb. Am J Physiol 1990;258:F1372-F1378.
55. Agmon Y, Brezis M. Effects of nonsteroidal anti-inflammatory drugs upon intrarenal blood flow: Selective medullary hypoperfusion. Exp Nephrol 1993;1:357-363.
56. Gerber JG, Nies AS. The hemodynamic effects of prostaglandins in the rat: Evidence for important species variation in renovascular responses. Circ Res 1979;44:406-410.
57. McDonald FD, Thiel G, Wilson DR, DiBona GF, Oken DE. The prevention of acute renal failure in the rat by long-term saline loading: A possible role of the renin-angiotensin axis. Proc Soc Exp Biol Med 1969;131:610-614.
58. Nygren A, Ulfendahl HR. Effects of high- and low-osmolar contrast media on renal plasma flow and glomerular filtration rate in euvolaemic and dehydrated rats. Acta Radiol 1989;30:383-389.
59. Cederholm C, Almén T, Bergqvist D, Golman K, Takolander R. Acute renal failure in rats: Interaction between contrast media and temporary renal arterial occlusion. Acta Radiol 1989;30: 321-326.
60. Verbaeys A, Van Maele G, De Sy W, Ringoir S, Lameire N. Absence of functional renal effects of uro-angiographic contrast media on post-ischemic rat kidneys. Acta Radiol 1991;32:325-328.
61. Leeming BWA, Spokes KC, Silva P. Effect of meglumine iothalamate on renal hemodynamics and function in the diabetic rat. Invest Radiol 1985;20:971-977.
62. Vaamonde CA, Bier RT, Papendick R, et al. Acute and chronic renal effects of radiocontrast in diabetic rats: Role of anesthesia and risk factors. Invest Radiol 1989;24:206-218.
63. Duarte CG, Ellis S. Renal effects of a radiocontrast agent in aging spontaneously hypertensive rats. In: Bianchi C, Bocci V, Carone FA, Rabkin R, eds. Kidney, proteins, and drugs. Contrib Nephrol 1990;83:222-228.
64. Verbaeys A, Ringoir S, Praet M, Van Maele G, Lameire N. Contrast media injection in the rat after multiple renal insult: No evidence of additional nephrotoxicity. Urol Res 1995;23:39-43.
65. Corman B, Pratz J, Poujeol P. Changes in anatomy, glomerular filtration, and solute excretion in aging rat kidney. Am J Physiol 1985;248:R282-R287.
66. Reinhard MK, Hottendorf GH, Powell ED. Differences in the sensitivity of Fischer and Sprague-Dawley rats to aminoglycoside nephrotoxicity. Toxicol Pathol 1991;19:66-71.
67. Hierholzer K. Value and necessity of animal research in nephrology. Exp Biol Med 1982;7:88-101.
68. Nygren A, Ulfendahl HR, Hansell P, Erikson U. Effects of intravenous contrast media on cortical and medullary blood flow in the rat kidney. Invest Radiol 1988;23:753-761.
69. Saito M, Homma S, Yamatsu I, Sato M, Ohshima N. Visualisation of renal microcirculation of the isolated Munich-Wistar rat kidneys: Effects of endothelin-1 on renal hemodynamic activity. Jpn J Pharmacol 1994;66:221-229.
70. Högström B, Hietala SO, Rooth P. In vivo fluorescence microscopy of microcirculation in the renal cortex of mice. Acta Radiol 1994;35:176-181.
71. Ueda J, Nygren A, Hansell P, Erikson U. Influence of contrast media on single nephron glomerular filtration rate in rat kidney. Acta Radiol 1992;33:596-599.
72. Alt JM, Maess B, Hackbarth H. Species and strain differences in urinary protein excretion. Renal Physiol 1985;8:301-309.
73. Bhargava AS, Hofmeister R, Siegmund F, Schöbel C, Günzel P. Effect of three non-ionic contrast media on rats and rabbits with regard to renal changes. Arzneimittelforschung 1990;40:822-829.
74. Vari RC, Natarajan LA, Whitescarver SA, Jackson BA, Ott CE. Induction, prevention, and mechanisms of contrast media-induced acute renal failure. Kidney Int 1988;33:699-707.
75. Deray G, Martinez F, Cacoub P, Baumelou B, Baumelou A, Jacobs C. A role for adenosine, calcium, and ischemia in radiocontrast-induced intrarenal vasoconstriction. Am J Nephrol 1990;10:316-322.
76. Erley C, Duda SH, Schlepckow S, et al. Adenosine antagonist theophylline prevents the reduction of glomerular filtration rate after contrast media application. Kidney Int 1994;45:1425-1431.
77. Neumayer HH, Junge W, Küfner A, Wenning A. Prevention of radiocontrast media-induced nephrotoxicity by the calcium channel blocker nitrendipine: A prospective randomised clinical trial. Nephrol Dial Transplant 1989;4:1030-1036.
78. Katzberg RW, Pabico RC, Morris TW, et al. Effects of contrast media on renal function and subcellular morphology in the dog. Invest Radiol 1986;21:64-70.
79. Oken DE. An analysis of glomerular dynamics in rat, dog, and man. Kidney Int 1982;22:136-145.
80. Kriz W. Structural organization of the renal medulla: Comparative and functional aspects. Am J Physiol 1981;241:R3-R16.
81. Terris JM. Swine as a model in renal physiology and nephrology: An overview. In: Tumbleson ME, ed. Swine in biomedical research. New York, NY: Plenum Press, 1986:1673-1689.
82. Parker JL, Adams R. The influence of chemical restraining agents on cardiovascular function: A review. Lab Anim Sci 1978;28: 575-583.
83. Conger JD, Burke TJ. Effects of anesthetic agents on autoregulation of renal hemodynamics in the rat and dog. Am J Physiol 1976;230:652-657.
84. Buchardi H, Kaczmarczyk G. The effect of anesthesia on renal function. Eur J Anaesth 1994;11:163-168.
85. Koechel DA, Bretz NS, Sanzenbacher RL, Tarloff JB, Budd GC. The pentobarbital anesthetized dog: An animal model for assessing chemically-induced changes in renal function and ultrastructure. Am J Vet Res 1984;45:2565-2573.
86. Brown P, Haylor J, Morcos SK, Cope GH, El Nahas AM. Effect of diatrizoate on the function of the isolated perfused rat kidney. Br J Radiol 1992;65:1011-1017.
87. Oldroyd S, Haylor J, Morcos SK. The acute effect of ioversol on kidney function: Role of endothelin. Eur J Radiol 1995;19:91-95.
88. Morcos SK, Brown PWG, Oldroyd S, El Nahas AM, Haylor J. Relationship between the diuretic effect of radiocontrast media and their ability to increase renal vascular resistance. Br J Radiol 1995;68:850-853.
89. Mattson DL, Lu S, Roman RJ, Cowley AW. Relationship between renal perfusion pressure and blood flow in different regions of the kidney. Am J Physiol 1993;264:R578-R583.
90. Castaing N, Merlet D, Cambar J. Les méthodes d'évaluation in vitro de la néphrotoxicité. J Tox Clin Exp 1990;10:73-87.
91. Toutain HJ. Néphrotoxicité in vitro: Modèles de cultures de cellules tabulaires rénales. In: Adolphe M, Guillouzo A, Marano F, eds. Toxicologie cellulaire in vitro: Méthodes et applications. Paris, France: INSERM, 1995:150-189.
92. 1 and MDCK). Am J Physiol 1985;248:F536-F544.
93. Idée JM, Bourbouze R. Effects of iodinated x-ray contrast media on renal epithelial cells in culture. Invest Radiol 1995;30:323-324. Letter.
94. Lagroye I, Lakhdar B, Potier M, Cambar J. Comparative contrast media-induced cytotoxicity in cultured rat mesangial cells and human fibroblasts. Presented at the 8th International Workshop on In Vitro Toxicology; September 20-23 1994; Kartause Itingen, Switzerland. Abstract.
95. Sraer JD, Adida C, Peraldi MN, Rondeau E, Kanfer A. Species-specific properties of the glomerular mesangium. J Am Soc Nephrol 1993;3:1342-1350.
96. Festing MFW. Reduction of animal use: Experimental design and quality of experiments. Lab Animals 1994;28:212-221.