Gene therapy approach in renal disease in the 21st century

Nephrology Dialysis Transplantation

Volumn 16, Issue SUPPL. 5, 2001, Pages 26-34

  Imai, Enyu ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Electroporation; HVJ liposome; Skeletal muscle; Transplant kidney

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BETA GALACTOSIDASE; BLEOMYCIN; CATION; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPOSOME; OLIGONUCLEOTIDE; PROTEIN; TRANSCRIPTION FACTOR; VIRUS DNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ELECTRIC CURRENT; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GRAFT REJECTION; IMMUNOGENICITY; KIDNEY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; MOUSE; NONHUMAN; OUTCOMES RESEARCH; PARAINFLUENZA VIRUS 1; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TOXICITY;

EID: 0034864995     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/16.suppl_5.26     Document Type: Article

References (79)

1. An overview of regular dialysis treatment in Japan as of December 31
2. Gene transfer into the kidney: Promise for unrevealing disease mechanisms, limitations for human gene therapy
3. Strategies for gene transfer to the kidney
4. Gene transfer in the kidney
5. New paradigm of gene therapy: Skeletal-muscle-targeting gene therapy for kidney disease
6. Gene transfer into the mammalian kidney: Direct retrovirus transduction of regenerating tubular epithelial cells
7. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
8. Gene therapy death prompts review of adenovirus vector
9. Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system-first steps towards gene therapy of Alport syndrome
10. Adeno-associate virus rep proteins target DNA sequences to a unique locus in the human genome
11. Recombinant adeno-associated virus integrates at diverse sites in the human genome
12. Expression of the human multidrug resistance and glucocerebrosidase cDNA from adeno-associated vectors: Efficient promoter activity of AAV sequences and in vivo delivery via liposomes
13. Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors
14. Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy
15. Renal uptake of an 18-mer phosphorothioate oligonucleotide
16. Liposome-mediated gene transfer into kidney tubules
17. The HVJ-liposome method
18. Direct in vivo gene introduction into rat kidney
19. Hepatocyte growth factor may function as a renotropic factor in rats with acute renal injury
20. In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced phenotypic change of the mesangial cells and glomerular sclerosis
21. Development and characterization of cationic liposomes conjugated with HVJ (Sendai Virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer
22. Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method
23. Sustained transgene expression in vitro and in vivo using an Epstein-Barr virus replicon vector system combined with HVJ liposome
24. Multiple EBNA-1 binding sites are required to form an EBNA-1-dependent enhancer and to activate a minimal replication origin within oriP of Epstein-Barr virus
25. Prolonged transgene expression in glomeruli using an Epstein-Barr virus replicon vector system combined with AVE type liposomes
26. Pulse-length dependence of the electrical breakdown in lipid bilayer membranes
27. Changes of membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy
28. The resealing process of lipid bilayers after reversible electrical breakdown
29. Study of mechanisms of electric field-induced DNA transfection 1. DNA entry by surface binding and diffusion through membrane
30. Electrochemotherapy: Potentiation of antitumor effect of bleomycin by local electric pulses
31. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA
32. Gene transfer into muscle by electroporation in vivo
33. High-efficiency gene transfer into skeletal muscle mediated by electric pulses
34. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation
35. Muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression
36. Efficient nonviral cutaneous transfection
37. In vivo gene electro-injection and expression in rat liver
38. Direct gene transfer into rat liver cells by in vivo electroporation
39. Foreign gene expression in the mouse testis by localized in vivo gene transfer
40. High efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene
41. High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation
42. Electroporation mediated gene transfer targeting glomeruli
43. Gene transfer into the rat renal glomerulus via a mesangial cell vector: Site-specific delivery, in situ amplification and sustained expression of an exogenous gene in vivo
44. Transfer of genetically engineered macrophages into the glomerulus
45. Inflamed site-specific gene delivery using bone marrow-derived CD11b+CD18+ vehicle cells in mice
46. Application of a gene transfer strategy to identify molecules that incite autoimmune kidney injury
47. Macrophage growth factors introduced into the kidney initiate renal injury
48. Molecular conjugate-mediated gene transfer into isolated human kidneys
49. Antisense oligonucleotides as therapeutic agents: Is the bullet really magical
50. Gene inhibition using antisense oligodeoxynucleotides
51. Inhibition of TGF-β expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis
52. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo
53. Inhibition of mesangial cell proliferation by E2F decoy oligonucleotide in vitro and in vivo
54. In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis
55. Transcription factor decoy for NFκB inhibits TNF-α-induced cytokine and adhesion molecule expression in vivo
56. Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells
57. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischaemia
58. In vivo suppression of the renal Na+/Pi cotransporter by antisense oligonucleotides
59. Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy
60. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery
61. Relationship between renal function and histologic changes found in renal-biopsy specimens from patients with persistent glomerulonephritis
62. Structural-functional correlations in renal disease. II. The correlations
63. Molecular insights into renal interstitial fibrosis
64. Transforming growth factor in tissue fibrosis
65. Introduction of transforming growth factor-β1 antisense oligodeoxynucleotides into renal interstitial fibroblasts blocks interstitial fibrosis in unilateral ureteral obstruction
66. Creation of a functioning chimeric mammalian kidney
67. Long-term-expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector
68. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion
69. Systemic inhibition of tumor growth and tumor metastasis by intramuscular administration of the endostatin gene
70. Intramuscular injection of expression plasmid DNA is an effective means of long-term systemic delivery of interleukin-5
71. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
72. Gene therapy by transforming growth factor-b receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis
73. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein
74. Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorated experimental glomerulonephritis
75. Treatment of murine lupus with cDNA encoding IFN-γR/Fc
76. Fas ligand gene transfer to renal allografts in rats
77. CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft
78. Effect of hepatocyte growth factor on chronic rejection in rat renal allografts