CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft

Journal of the American Society of Nephrology

Volumn 11, Issue 4, 2000, Pages 747-752

  Tomasoni, Susanna ^a   Azzollini, Nadia ^a   Casiraghi, Federica ^a   Capogrossi, Maurizio C ^b   Remuzzi, Giuseppe ^a   Benigni, Ariela ^a,c  

^a OSPEDALI RIUNITI   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c MARIO NEGRI INST PHARMACOL RES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; RECOMBINANT PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE TRANSFER; GENETIC MANIPULATION; GRAFT SURVIVAL; IMMUNOMODULATION; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; MALE; MIXED LYMPHOCYTE CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0034026805     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Dunn DL: Problems related to immunosuppression. Crit Care Clin 6: 955-977, 1990
2. Benigni A, Remuzzi G: Transplant tolerance. Lancet 351: 1749-1751, 1998
3. Lau HT, Yu M, Fontana A, Stoeckert CJ Jr: Prevention of islet allograft rejection with engineered myoblasts expressing fasL in mice. Science 273: 109-112, 1996
4. Kang S-M, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S: Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med 3: 738-743, 1997
5. Tomasoni S, Lutz J, Corna D, Capogrossi M, Remuzzi G, Benigni A: Adenoviral gene transfer in renal transplantation [Abstract]. J Am Soc Nephrol 8: 667A, 1997
6. June C, Bluestone J, Nadler L, Thompson CB: The B7 and CD28 receptor families. Immunol Today 15: 321-331, 1994
7. Sayegh MH: Finally, CTLA4Ig graduates to the clinic. J Clin Invest 103: 1223-1225, 1999
8. Sayegh MH, Turka LA: The role of T-cell costimulatory activation in transplant rejection. N Engl J Med 338: 1813-1821, 1998
9. Perico N, Amuchastegui S, Bontempelli M, Remuzzi G: CTLA4Ig alone or in combination with low-dose cyclosporine fails to reverse acute rejection of renal allograft in the rat. Transplantation 61: 1320-1322, 1996
10. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA: Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257: 789-792, 1992
11. Judge TA, Wu Z, Zheng X-G, Sharpe AH, Sayegh MH, Turka LA: The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol 162: 1947-1951, 1999
12. Chahine AA, Yu M, McKernan MM, Stoeckert C, Lau HT: Immunomodulation of pancreatic islet allografts in mice with CTLA4Ig secreting muscle cells. Transplantation 59: 1313-1318, 1995
13. Olthoff KM, Judge TA, Gelman AE, da Shen X, Hancock WW, Turka LA, Shaked A: Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med 4: 194-200, 1998
14. Reyes J, Zeevi A, Ramos H, Tzakis A, Todo S, Demetris AJ, Nour B, Nalesnik M, Trucco M, Abu-Elmagd K, Fung JJ, Starzl TE: Frequent achievement of a drug-free state after orthotopic liver transplantation. Transplant Proc 25: 3315-3319, 1993
15. Kita Y, Li X-K, Hayashi S, Funeshima N, Enosawa S, Tamura A, Suzuki K, Kazui T, Amemiya H, Suzuki S: Prolonged rat cardiac allograft survival using adenoviral vector containing the CTLA4Ig gene. Transplant Proc 30: 1079-1080, 1998
16. Mühlhauser J, Merrill MJ, Pili R, Maeda H, Bacic M, Bewig B, Passaniti A, Edwards NA, Crystal RG, Capogrossi MC: VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo. Circ Res 77: 1077-1086, 1995
17. Noris M, Azzollini N, Mister M, Pezzotta A, Piccinini G, Casiraghi F, Cugini D, Perico N, Orisio S, Remuzzi G: Peripheral donor leukocytes prolong survival of rat renal allografts. Kidney Int 56: 1101-1112, 1999
18. Zhu G, Nicolson AG, Cowley BD, Rosen S, Sukhatme VP: In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. Gene Ther 3: 298-304, 1996
19. Yang Y, Li O, Ertl HCJ, Wilson JM: Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 67: 2004-2015, 1995
20. Dai Y, Schwarz EM, Gu D, Zhang W-w, Sarvetnick N, Verma IM: Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 92: 1401-1405, 1995
21. Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science 272: 50-54, 1996
22. Amuchastegui SC, Azzollini N, Mister M, Pezzotta A, Perico N, Remuzzi G: Chronic allograft nephropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism. J Am Soc Nephrol 9: 1948-1955, 1998
23. Mackenzie HS, Azuma H, Rennke HG, Tilney NL, Brenner BM: Renal mass as a determinant of late allograft outcome: Insights from experimental studies in rats. Kidney Int 48[Suppl 52]: S38-S42, 1995
24. Kirk AD, Burkly LC, Batty DS, Baumgartner RE, Berning JD, Buchanan K, Fechner JH, Germond RL, Kampen RL, Patterson NB, Swanson SJ, Tadaki DK, TenHoor CN, White L, Knechtle SJ, Harlan DM: Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 5: 686-693, 1999