The activation of a neocentromere in Drosophila requires proximity to an endogenous centromere

Genetics

Volumn 158, Issue 4, 2001, Pages 1615-1628

  Maggert, Keith A ^a   Karpen, Gary H ^b  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTROMERE; CHROMOSOME DAMAGE; CHROMOSOME LOSS; DROSOPHILA MELANOGASTER; EUCHROMATIN; GENETIC LINKAGE; HETEROCHROMATIN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOTTING, SOUTHERN; CENTROMERE; CHROMATIN; CHROMOSOMES; CROSSES, GENETIC; DNA; DROSOPHILA; FEMALE; GAMMA RAYS; MALE; MODELS, GENETIC; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 0034845229     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (112)

1. Pericentromeric regions containing 1.688 satellite DNA seuences show anti-kinetochore antibody staining in prometahase chromosomes of Drosophila melanogaster
2. The genome sequence of Drosophila melanogaster
3. A dicentric chromosome of Drosophila melanogaster showing alterate centromere inactivation
4. The transmission of fragmented chromosomes in Drosophila melanogaster
5. Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis
6. Position effect variegation at fission yeast centromeres
7. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation
8. Sequence analysis of an 80 kb human neocentromere
9. The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: Further evidence for epigenetic modification
10. Chromosome ends in Drosophila without telomeric DNA sequences
11. The role of Drosophila CENP-A/CID in kinetochore formation, cell-cycle progression and interactions with heterochromatin
12. Non-disjunction as proof of the chromosome theory of heredity
13. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meio-sis
14. Centromere DNA dynamics: Latent centroeres and neocentromere formation
15. Turning on the centromere
16. Interchromoomal transfer of epigenetic states in Ascobolus: Transfer of DNA methylation is mechanistically related to homologous recombinaion
17. Something from nothing: The evolution and utility of satellite repeats
18. Misdivision and the genetics of the centroere
19. Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA
20. Perturbation of nuclear architecture by long-distance chromosome interactions
21. Centromere proteins and chromosome inheritance: A complex affair
22. Identification of chromosome inheritance modifiers in Drosophila melanogaster
23. Trans-suppression of terminal deficiency-associated position effect variegation in a Drosophila minichromosome
24. Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans
25. The enhancer of position-effect variegation of Drosophila E(var) 3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators
26. A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA
27. Transient inhibition of histone deactylation alters the structural and functional imprint at fission yeast centroeres
28. Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation
29. Probing the architecture of a simple kinetochore using DNA-protein crosslinkng
30. Chromatin organization and transcriptional control of gene expression in Drosophila
31. Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres
32. Beitrag zur kenntnis der zelle und ihrer lebnserscheinungen
33. Imprinted conrol of gene activity in Drosophila
34. Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis
35. Formation of de novo centromeres and construction of first-generation human artificial minichro-mosomes
36. Nuclear organization and gene expression: Hoologous pairing and long-range interactions
37. Heterochromatic deposition of centromeric histone H3-like proteins
38. Paramutaion and related allelic interactions
39. Structure and function of kinetochores in budding yeast
40. Construction of YAC-based mammalian artificial chromosomes
41. Preparation and analysis of high-molecularweight DNA in Drosophila
42. The case for epigenetic effects on centromere identity and function
43. Reduced DNA polytenizaion of a minichromosome region undergoing position-effect variegation in Drosophila
44. Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis
45. Centric heterochromatin and the efficiency of achiasmate disjunction in Drosophila female meiosis
46. Epigenetic spreading of the Drosophila dosage compensation complex from roXRNA genes into flanking chromatin
47. Neocentromeres and alpha satellite: A proposed strucural code for functional human centromere DNA
48. Genetic and molecular analysis of terminal deletions of chromosome 3R of Drosophila melanogaster
49. Islands of complex DNA are widespread in Drosophila centric heterochromatin
50. Replication of heterochromatin and structure of polytene chromosomes
51. Localization of the genetic factors responsible for the kinetic activity of X chromosomes of Drosophila melanogaster
52. Segmental aneuploidy and the genetic gross structure of the Drosophila genome
53. Sisterhromatid cohesion via MEI-S322 and kinetochore assembly are separable functions of the Drosophila centromere
54. Organization of DNA sequences near the centromere of the Drosophila melanogaster Y chromosome
55. DNA methylation in Drosophila melanogaster
56. Acquisition and metastabilty, of centromere identity and function: Sequence analysis of a human neocentromere
57. mu-2: Mutator gene in Drosophila that potentiates the induction of terminal deficiencies
58. Localization of terminal deficiency breakpoints on the X-chromosome
59. Germ-line effects of a mutator, mu2, in Drosophila melanogaster
60. Interactions between the nod+ kinesin-like gene and extracentromeric sequences are required for transmission of a Drosophila minichromosome
61. Localization of centroere function in a Drosophila minichromosome
62. Centromeres take flight: Alpha satellite and the quest for the human centromere
63. The genetic consequences of anaphase bridge formation in Drosophila
64. Genetic measures of centromere activity in Droophila melanogaster
65. Nuclear structure and the microdistribution of radiation damage in DNA
66. Chromosome stability is mainained by short intercentromeric distance in functionally dicenric human Robertsonian translocations
67. Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone
68. The genetic identification of a heterochromatic segment on the X chromosome of Drosophila melanogaster
69. Distinct protein interaction domains and protein spreading in a complex centromere
70. Adistal heterochroatic block displays centromeric activity when detached from a natural centromere
71. The centromere: Hub of chromosomal activities
72. The vertebrate cell kinetohore and its roles during mitosis
73. Human centromeres and neocentroeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins
74. The structure of the kinetochore at meiosis
75. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites
76. Chromatin assembly at kinetochores is uncoupled from DNA replication
77. Position-effect variegation in Drosophila
78. ZW10 helps recruit dynactin and dynein to the kinetochore
79. A novel epigenetic effect can alter centromere function in fission yeast
80. Centromere identity in Drosophila is not determined in vivo by replication timing
81. Stable dicentric X chromosomes with two functional centromeres
82. Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere
83. Molecular structure of a functional Drosophila centromere
84. The elusive centromere: Sequence divergence and functional conservation
85. A reexamination of spreading of position-effect variegation in the white-roughest region of Droophila melanogaster
86. Epigenetic inheritance of transcripional silencing and switching competence in fission yeast
87. The size and internal structure of a heretochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster
88. Prefrential transposition of Drosophila Pelements to nearby chromoomal site
89. The behavior of the centromere at meiosis
90. Chromatin containing CENPA and α-satellite DNA is a major component of the inner kinetohore plate
91. Sequence of centromere separation: Role of centroeric heterochromatin
92. Localization of antiENP antibodies and alphoid sequences in acentric heterochroatin in a breast cancer cell line
93. A functional marker centromere with no detectable alphasatellite, satellite 111, or CENP-B protein: Activation of a latent centromere?
94. Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila
95. Unfolding the mysteries of heterochromatin
96. Hamster chromosomes containing amplified human α-satellite DNA show delayed sister chromatid separation in the absence of de novo kinetochore foration
97. Molecular cytogenetic analysis of eight inversion duplicaions of human chromosome 13q that each contain a neocentroere
98. Variation in radiationnduced formation of DNA double-strand breaks as a function of chromatin structure
99. Centromeric chromatin and epigenetic effects in kinetochore assembly
100. Centromeres of mammalian chromosomes
101. Human artificial chromosomes coming into focus
102. Neocentromere activity of a structurally acentric minichromosome in Drosophila
103. Somatic instability of a Drosophla chromosome
104. The centroere-kinetochore complex: A repeat subunit model