The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster

Genetics

Volumn 154, Issue 4, 2000, Pages 1611-1626

  Tolchkov, Eugene V ^a   Rasheva, Vanya I ^a   Bonaccorsi, Silvia ^b   Westphal, Thomas ^a   Gvozdev, Vladimir A ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME DELETION; DROSOPHILA MELANOGASTER; GENE LOCATION; GENE REARRANGEMENT; GENE STRUCTURE; HETEROCHROMATIN; POSITION EFFECT; PRIORITY JOURNAL;

ANIMALS; DROSOPHILA MELANOGASTER; FEMALE; GENE REARRANGEMENT; HETEROCHROMATIN; LINKAGE (GENETICS); MALE; X CHROMOSOME; Y CHROMOSOME;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0034040614     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. ALATORTSEV, V. E., E. V. TOLCHKOV, S. Y. SLOBODYANYUK and V. A. GVOZDEV, 1982 Cellular variegation and antigen disappearance as a result of the position effect of the Pgd locus in Drosophila melanogaster. Genetika (Russ.) 18: 13-23.
2. ALATORTSEV, V. E., I. A. KRAMEROVA, M. V. FROLOV, S. A. LAVROV and E. D. WESTPHAL, 1997 Vinculin gene non-essential in Drosphila melanogaster. FEBS Lett. 413: 197-201.
3. BAKER, W. K., 1954 The anatomy of the heterochromatin. Data on the physical distance between breakage point and the affected locus in V-type position effect. J. Hered. 45: 65-68.
4. CSINK, A. K., and S. HENIKOFF, 1996 Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature 381: 529-531.
5. DERNBURG, A. F., K. W. BROMAN, J. C. FENG, W. F. MARSHALL, J. PHILIPS et al., 1996 Perturbation of nuclear architecture by long-distance chromosome interaction. Cell 85: 745-759.
6. DORER, D. R., and S. HENIKOFF, 1994 Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77: 993-1002.
7. DORER, D. R., and S. HENIKOFF, 1997 Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans. Genetics 147: 1181-1190.
8. EBERL, D. F., B. J. DUYF and A. J. HILLIKER, 1993 The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Genetics 134: 277-292.
9. GATTI, M., and S. PIMPINELLI, 1992 Functional elements in D. melanogaster heterochromatin. Annu. Rev. Genet. 26: 239-275.
10. GATTI, M., S. BONACCORSI and S. PIMPINELLI, 1994 Looking for Drosophila mitotic chromosomes. Methods Cell Biol. 44: 371-391.
11. GRIGLIATTE, T., 1991 Position effect variegation: an essay for nonhistone chromosomal proteins and chromatin assembly and modifying factors, pp. 587-627 in Functional Organization of the Nucleus: A Laboratory Guide, edited by B. A. HAMKALI and S. C. R. ELGIN. Academic Press, San Diego.
12. GYOZDEV, V. A., S. A. GOSTIMSKY, T. I. GERASIMOVA, E. S. DUBROVSKAYA and O. Y. BRASLAVSKAYA, 1975 Fine genetic structure of the 2D3-2F5 region of the X chromosome of D. melanogaster. Mol. Gen. Genet. 141: 269-275.
13. HENIKOFF, S., 1990 Position effect variegation after 60 years. Trends Genet. 6: 422-426.
14. HENIKOFF, S., 1997 Nuclear organizations and gene expression: homologous pairing and long range interactions. Curr. Opin. Cell Biol. 9: 388-395.
15. Dominant heterochromatic elements in Drosophila. Genetics 140: 1007-1017.
16. HILLIKER, A. J., and C. B. SHARP, 1988 New perspectives on the genetic and molecular biology of constitutive heterochromatin, pp. 91-115 in Chromosome Structure and Function, edited by J. P. GUSTAFSON, R. APPELS and R. KAUFMAN. Plenum, New York.
17. HOWE, M., P. DIMITRI, M. BERLOCO and B. T. WAKIMOTO, 1995 Cis-effects of heterochromatin on heterochromatic and euchromatic gene activity in D. melanogaster. Genetics 140: 1033-1045.
18. ILYINA, O. V., A. V. SOROKIN, E. S. BELYAEVA and I. F. ZHIMULEV, 1980 New mutants. Dros. Inf. Serv. 55: 205.
19. JENUWEIN, T., G. LAIBLE, R. DORN and G. REUTER, 1998 SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell. Mol. Life Sci. 54: 80-93.
20. KONEV, A. Y., 1994 Proximity dependent interaction between heterochromatic regions may be important for euchromatic loci position effect variegation. 35th Annual Drosophila Research Conference, Chicago. 325B.
21. KONEV, A. Y., 1995 Cytogenetical study of 44F-45D region of chromosome 2 in D. melanogaster. Ph.D. Thesis, Sanct-Petersburgh. (Russian).
22. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of D. melanogaster. Academic Press, San Diego.
23. LOHE, A. R., and A. J. HILLIKER, 1995 Return of the H-word (heterochromatin). Curr. Opin. Genet. Dev. 5: 746-755.
24. LOHE, A. R., A. J. HILLIKER and P. A. ROBERTS, 1993 Mapping simple reprated DNA sequences in heterochromatin of D. melanogaster. Genetics 134: 1149-1174.
25. MAKUNIN, I. V., G. V. POKHOLKOVA, S. O. ZAKHARKIN, N. G. KHOLODILOV and I. F. ZHIMULEV, 1995 Isolation and characterization of the repeated DNA sequences from the centric heterochromatin of the second chromosome of D. melanogaster. Dokl. Akad. Nauk (Russ.) 344: 266-269.
26. MCKEE, B. D., 1996 The licence to pair: identification of meiotic pairing sites in Drosophila. Chromosoma 105: 135-141.
27. PANSHIN, I. B., 1938 The cytogenetic nature of the position effect of the genes white (mottled) and cubitus interruptus. Biologicheskij Z. 7: 837-868.
28. PIMPINELLI, S., M. BERLOCO, L. FANTI, P. DMITRI, S. BONACCORSI et al., 1995 Transposable elements are stable structural components of Drosophila melanogaster heterochromatin. Proc. Natl. Acad. Sci. USA 92: 3804-3808.
29. POKHOLKOVA, G. V., I. V. MAKUNIN, E. S. BELYAEVA and I. F. ZHIMULEV, 1993 Observation on the induction of position effect variegation of euchromatic genes in D. melanogaster. Genetics 134: 231-242.
30. REUTER, G., and P. SPIERER, 1992 Position effect variegation of euchromatic genes in D. melanogaster. Bioessays 14: 605-612.
31. SPOFFORD, J. B., 1976 Position effect variegation in Drosophila, pp. 955-1019 in Genetics and Biology of Drosophila, edited by M. ASHBURNER and E. VOVITSKI. Academic Press, London.
32. SUN, X., J. WAHLSTROM and G. KARPEN, 1997 Molecular structure of a functional Drosophila centromere. Cell 91: 1007-1019.
33. Dominant by linkage alteration. Genetics 136: 559-571.
34. TARTOF, K. D., C. HOBBS and M. JONES, 1984 A structural basis for variegation position effects. Cell 37: 869-878.
35. TOLCHKOV, E. V., M. D. BALAKIREVA and V. E. ALATORTSEV, 1984 Inactivation of the X chromosome region with a known fine genetic structure as a result of the variegated position effect in D. melanogaster. Genetika (Russ.) 20: 1846-1856.
36. TOLCHKOV, E. V., I. A. KRAMEROVA, S. A. LAVKOV, V. I. RASHEVA, S. BONACCORSI et al., 1997 Variegated position effect in D. melanogaster X chromosome inversions with a breakpoint in satellite block. Chromosoma 106: 520-525.
37. WAKIMOTO, B. T., and M. G. HEARN, 1990 The effect of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of D. melanogaster. Genetics 125: 141-154.
38. WEILER, K. S., and B. T. WAKIMOTO, 1995 Heterochromatin and gene expression in Drosophila. Annu. Rev. Genet. 29: 577-605.
39. WEILER, K. S., and B. T. WAKIMOTO, 1998 Chromosome rearrangements induce both variegated and reduced, uniform expression of heterochromatic genes in a development-specific manner. Genetics 149: 1451-1464.
40. ZHIMULEV, I. F., 1998 Polytene chromosomes, heterochromatin and position effect variegation. Adv. Genet. 37: 1-566.