Cox-2 inhibitors and other nonsteroidal anti-inflammatory drugs in the treatment of pain in the elderly

Clinics in Geriatric Medicine

Volumn 17, Issue 3, 2001, Pages 489-502

  Bell, Gregory M ^a   Schnitzer, Thomas J ^b  

^a Abgenix Inc   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450 2C9; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN H2; ROFECOXIB; THROMBOXANE A2;

AGING; ALZHEIMER DISEASE; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; CANCER PREVENTION; CLINICAL TRIAL; COLON CANCER; DIGESTIVE SYSTEM PERFORATION; DRUG DISPOSITION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DYSPEPSIA; ELECTROLYTE DISTURBANCE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TOXICITY; HEART INFARCTION; HUMAN; INTESTINE OBSTRUCTION; NEPHROTOXICITY; OSTEOARTHRITIS; PAIN; REVIEW; RHEUMATOID ARTHRITIS; STROKE;

EID: 0034844573     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0749-0690(05)70082-3     Document Type: Article

References (51)

1. Current status of nonsteroidal anti-inflammatory drug (NSAID) use in the United States: Risk factors and frequency of complications
2. Colorectal cancer prevention and treatment
3. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
4. Celecoxib: A COX-2 inhibitor for the treatment of osteoarthritis and rheumatoid arthritis
5. Effects of nonsteroidal anti-inflammatory drugs on renal function: Focus on cyclooxygenase-2-selective inhibition
6. Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: Results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip
7. Basic biology and clinical application of specific cyclooxygenase-2 inhibitors
8. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in health humans
9. Selective inhibitors of cyclooxygenase-2. Potential in elderly patients
10. Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans
11. Postoperative pain management in the frail and elderly
12. Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model
13. Analgesic abuse in the elderly
14. Tolerability of topical NSAIDs in the elderly. Do they really convey a safety advantage?
15. The renal effects of nonsteroidal anti-inflammatory drugs in older people: Findings from the established populations for epidemiologic studies of the elderly: Clinical investigation
16. Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study
17. Pharmacology and efficacy of cyclooxygenase (COX) inhibitors
18. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs
19. Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease
20. Clinical implications of osteoarthritis and aging
21. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal anti-inflammatory drugs
22. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor) ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis
23. Progress in prophylaxis against nonsteroidal anti-inflammatory drugassociated ulcers and erosions
24. Update on aspirin in the treatment and prevention of cardiovascular disease
25. Consumption of non-steroidal anti-inflammatory drugs and the development of functional renal impairment in elderly subjects. Results of a case-control study
26. Nonsteroidal anti-inflammatory drugs and cognitive function. Do they have a beneficial or deleterious effect
27. Nonsteroidal anti-inflammatory drug gastropathy
28. Effect of anti-inflammatory drugs on overall risk of common cancer: Case-controlled study in general practice research database
29. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs
30. General tolerability and use of nonsteroidal anti-inflammatory drugs
31. Acute and chronic effects of nonsteroidal antiinflammatory drugs on glomerular filtration rate in elderly patients
32. Suppression of intestinal polyposis in Apc delta 716 knockout mice by inhibition of cyclooxygenase-2 (COX-2)
33. Consumption of NSAIDs and the development of congestive heart failure in elderly patients. An underrecognized public health problem
34. Gastropathy induced by nonsteroidal antiinflammatory drugs: Prescribing patterns among geriatric practitioners: Original contribution
35. NSAIDs and the elderly. Toxicity and economic implications
36. Is cyclooxygenase-2 the alpha and the omega in cancer?
37. Clinical trial of indomethacin in Alzheimer's disease
38. Nonsteroidal anti-inflammatory drugs and cognitive decline in the elderly
39. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs
40. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
41. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis
42. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy
43. Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons
44. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
45. Nonsteroidal anti-inflammatory drugs and dyspepsia in the elderly
46. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: Physiologic foundations and clinical implications
47. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
48. The pharmacokinetics of nonsteroidal anti-inflammatory drugs in the elderly
49. Comparison of omeprazole and ranitidine for treating and preventing ulcers associated with nonsteroidal anti-inflammatory drugs: The ASTRONAUNT study