Computational modeling of eukaryotic mRNA turnover

RNA

Volumn 7, Issue 9, 2001, Pages 1192-1212

  Cao, Dan ^a   Parker, Roy ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Degradation; Eukaryotic; Modeling; mRNA; Multicomponent

Indexed keywords

MESSENGER RNA;

ARTICLE; GENE EXPRESSION REGULATION; HALF LIFE TIME; MATHEMATICAL MODEL; MESSENGER RNA SYNTHESIS; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RNA DEGRADATION; TRANSCRIPTION REGULATION;

BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; EUKARYOTIC CELLS; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; MODELS, GENETIC; RNA CAPS; RNA, FUNGAL; RNA, MESSENGER; SOFTWARE;

EUKARYOTA;

EID: 0034839596     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201010330     Document Type: Article

References (29)

1. The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex
2. Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA
3. Degradation of mRNA in eukaryotes
4. An essential component of the decapping enzyme required for normal rates of mRNA decay in yeast
5. Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant
6. Identification of a regulated pathway for nuclear pre-mRNA turnover
7. Poly (A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation
8. mRNA turnover in yeast promoted by the MATα1 instability element
9. A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation
10. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional Mut motif
11. Control of translation initiation in animals
12. Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae
13. Mechanisms of mRNA surveillance in eukaryotes
14. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′ end formation of nascent transcripts
15. Poly (A) metabolism and translation: The closed-loop model
16. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′ → 3′ digestion of the transcript
17. Turnover mechanisms of the stable yeast PGK1 mRNA
18. Mutations affecting stability and deadenylation of the yeast MFA2 transcript
19. Aberrant mRNAs with extended 3′UTR are substrates for rapid degradation by mRNA surveillance
20. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
21. The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast
22. Measurement of mRNA decay rates in Saccharomyces cerevisiae
23. Starting at the beginning, middle and end: Translation initiation in eukaryotes
24. Mutations in translation initiation factors lead to increased rate of deadenylation and decapping of yeast mRNAs
25. mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E
26. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay
27. Yeast Sm-like proteins function in mRNA decapping and decay
28. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae
29. The rate-limiting step in yeast PGK1 mRNA degradation is an endonucleolytic cleavage in the 3′ terminal part of the coding region