Analysis of a phenobarbitai-responsive enhancer sequence located in the 5' flanking region of the chicken CYP2H1 gene: Identification and characterization of functional protein-binding sites

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 14-22

  Dogra, Satish C ^a   Davidson, Benjamin P ^a   May, Brian K ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENZYME; NUCLEAR FACTOR I; PHENOBARBITAL; PROTEIN; RESTRICTION ENDONUCLEASE; TRANSCRIPTION FACTOR; DEOXYRIBONUCLEASE I;

ANIMAL CELL; ARTICLE; BASE PAIRING; BINDING SITE; CHICKEN; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; ENHANCER REGION; GENE; GENE DELETION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; CHICK EMBRYO; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CHICK EMBRYO; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYRIBONUCLEASE I; ENHANCER ELEMENTS (GENETICS); MUTAGENESIS, SITE-DIRECTED; PHENOBARBITAL; TRANSCRIPTION FACTORS;

EID: 0032589805     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.14     Document Type: Article

References (36)

1. Burbach KM, Poland A and Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89:8185-8189.
2. Cereghini S, Raymondjean M, Carranca AG, Herbomel P, and Yaniv M (1987) Factors involved in control of tissue-specific expression of albumin gene. Cell 50:627-638.
3. Chodosh LA, Baldwin AS, Carthew RW, and Sharp PA (1988) Human CAAT-binding proteins have heterologous subunits. Cell 53:11-24.
4. Clark AR, Boam DS, and Docherty K (1989) A new series of CAT expression vectors. Nucleic Acids Res 17:10130.
5. Dailey LS, Roberts B, and Heintz N (1988) Purification of the human histone H4 gene-specific transcription factors H4TF-1 and H4TF-2. Genes Dev 2:1700-1712.
6. Denison MS and Whitlock JP (1995) Xenobiotic-inducible transcription of cytochrome P450 genes. J Biol Chem 270:18175-18178.
7. Dogra SC and May BK (1996) Phenobarbital-induced activation of CYP2H1 and 5-aminolevulinate synthase genes in chick embryo hepatocytes is blocked by an inhibitor of protein phosphorylation. Arch Biochem Biophys 327:271-278.
8. Dogra SC and May BK (1997) Liver enriched transcription factors, HNF-1, HNF-3, and C/EBP are major contributors to the strong activity of the chicken CYP2H1 promoter in chick embryo hepatocytes. DNA Cell Biol 16:1407-1418.
9. Dogra SC, Whitelaw ML and May BK (1998) Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers. Clin Exp Pharmacol Physiol 25:1-9.
10. Gonzalez FJ (1990) Molecular genetics of the P-450 superfamily. Pharmacol Ther 45:1-38.
11. Gorman CM, Moffat LF and Howard BH (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051.
12. Gorski K, Carneiro M and Schibler U (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47:767-776.
13. Grange T, Roux J, Rigaud G and Pictet R (1991) Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res 19:131-139.
14. Hahn CH, Hansen AJ and May BK (1991) Transcriptional regulation of the chicken CYP2H1 gene. J Biol Chem 266:17031-17039.
15. Hansen AJ, May BK and Elferink LA (1989) Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes DNA 8:179-191
16. He JS and Fulco AJ (1991) A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. J Biol Chem 266:7864-7869.
17. Honkakoski P, Moore R, Washburn KA and Negishi M (1998) Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol 53:597-601
18. Honkakoski P and Negishi M (1997) Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J Biol Chem 272:14943-14949.
19. Issemann I and Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond) 347:645-650.
20. Kim J and Kemper B (1997) Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital responsive unit in native chromatin. J Biol Chem 272:29423-29425.
21. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Wilson TM, Zetterström RH, Perlmann T and Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signalling pathway. Cell 92:73-82.
22. Landschulz WH, Johnson PF, Adashi EY, Graves BJ and McKnight L (1988) Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev 2:786-800.
23. Lassar AB, Buskin JN, Lockshon D, Davis RL, Apone S, Hauschkaand SD and Weintraub H (1989) MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell 58:823-831.
24. Mattschoss LA, Hobbs AA, Steggles AW, May BK and Elliott WH (1986) Isolation and characterization of genomic clones for two chicken phenobarbital-inducible cytochrome P-450 genes. J Biol Chem 261:9438-9443.
25. Maxam AM and Gilbert W (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol 65:499-560 (1980).
26. Okey AB (1990) Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 45:241-298.
27. Park Y, Li H and Kemper B (1996) Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J Biol Chem 271: 23725-23728.
28. Prabhu L, Upadhya P, Ram N, Nirodi CS, Sultana S, Vatsala PG, Mani SA, Rangarajan PN, Surolia A and Padmanaban GA (1995) A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver. Proc Natl Acad Sci USA 92:9628-9632.
29. Rey-Campos J, Chouard T, Yaniv M and Cereghini S (1991) vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO (Eur Mol Biol Organ) J 10:1445-1457.
30. Sawadogo M and Roeder RG (1985) Interaction of a gene-specific transcription actor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165-175.
31. Schreiber E, Matthias P, Muller MM and Scaffner W (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:6419.
32. Shaw GC and Fulco AJ (1993) Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-inducible cytochrome P450BM-3 gene of Bacillus megaterium. J Biol Chem 269:2997-3004.
33. BM-1 in Bacillus megaterium. J Biol Chem 273:7996-8002.
34. Stoltz C, Vachon MH, Trottier E, Dubois S, Paquet P and Anderson A (1998) The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J Biol Chem 273:8528-8536.
35. Trottier E, Belzil A, Stoltz C and Anderson A (1995) Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene. Gene (Amst) 158:263-268.
36. Waxman DJ and Azaroff L (1992) Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 281:577-592.