Antiproliferative activity of an aqueous mistletoe extract in human tumor cell lines and xenografts in vitro

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 9, 2001, Pages 748-757

  Burger, A M ^a   Mengs, U ^a   Schuler J B ^a   Fiebig, H H ^a  

^a Madaus AG   (Germany)

Author keywords

CAS 23214 92 8; Doxorubicin; Lektinol; Mistletoe extract, antiproliferative activity in vitro, human tumor cell lines, xenografts; Mistletoe lectin

Indexed keywords

AGAR; DOXORUBICIN; PROPIDIUM IODIDE; SULFORHODAMINE B; VISCUM ALBUM EXTRACT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRAIN U937; CHEMOSENSITIVITY; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG ISOLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; TUMOR CELL LINE; TUMOR XENOGRAFT;

EID: 0034837768     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300110     Document Type: Article

References (35)

1. Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review
2. Mistletoe treatment for cancer. Review of controlled trials in humans
3. Mistletoe lectins and their A and B chains
4. The site of action of the A chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidases activity of the protein
5. Ribosome-inactivating proteins from plants
6. In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis)
7. Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells. Cytotoxicity, apoptosis and induction of cytokines
8. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis
9. Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins
10. Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract
11. Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes
12. Stimulation of cytokine production via a special standardized mistletoe preparation in an in vitro human skin bioassay
13. Mistletoe lectin I-induced effects on human cytotoxic lymphocytes I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity
14. Biological effects of natural and recombinant mistletoe lectin and an aqueous mistletoe extract on human monocytes and lymphocytes in vitro
15. Effects of a standardized mistletoe preparation on metastatic B 16 melanoma colonization in murine lungs
16. Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB 49 in mice
17. The clonogenic assay with human tumor xenografts: Evaluation, predictive value and application for drug screening
18. Primary bioassay of human tumor stem cells
19. Development of a propidium iodide fluorescence assay for proliferation and cytotoxicity assays
20. New colorimetric cytotoxicity assay for anticancer-drug screening
21. Preclinical activity of hepsulfan and busulfan in solid human tumor xenografts and human bone marrow
22. In U-937 promonocytes, mistletoe lectin I increases basal [Ca2+]i, enhances histamine H1- and complement C5a-receptor-mediated rises in [Ca2+]i, and induces cell death
23. Biochemical, histochemical and cell biological investigations on the actions of mistletoe lectins I, II and III with human breast cancer cell lines
24. Growth stimulation of non-small cell lung cancer xenografts by granulocyte-macrophage colony-stimulating factor (GM-CSF)
25. Immunomodulating mistletoe therapy by lectin standardization: A double-edged sword?
26. Evidence for stimulation of tumor proliferation in cell lines and histotypic cultures by clinically relevant low doses of the galactoside-binding mistletoe lectin, a component of proprietary extracts
27. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
28. Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5500 with altered glycoprotein expression in vitro
29. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
30. Selective modulation of phosphatidylserine exposure on subpopulations of human peripheral blood lymphocytes by a plant lectin, Viscum album agglutinin (VAA)-I and its recombinant form (rVAA) in vitro
31. Mode of action of rML: Triggering of specific signalling pathways is probably due to intracellular ribosome-inactivation
32. Cytotoxic activity of recombinant bFGF-rViscumin fusion proteins
33. Recombinant mistletoe lectin (rML) is a potent inhibitor of tumor cell growth in vitro and in vivo