Adenovirus-mediated Bcl-2 gene transfer inhibits apoptosis and promotes survival of allogeneic transplanted hepatocytes

Surgery

Volumn 130, Issue 3, 2001, Pages

  Song, Erwei ^a,b,c   Chen, Jisheng ^a,b   Antus, Balazs ^a,b   Su, Fengxi ^a,b   Wang, Minghui ^a,b   Exton, Michael S ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADCMVHBCL 2; ALANINE AMINOTRANSFERASE; CASPASE 3; DNA FRAGMENT; DNA POLYMERASE; FAS ANTIBODY; FAS LIGAND; GRANZYME B; PROTEIN BCL 2; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME INHIBITION; ENZYME RELEASE; GENE EXPRESSION; GENE TRANSFER; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER TRANSPLANTATION; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE;

EID: 0034835286     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2001.116027     Document Type: Article

References (47)

1. Systematic analysis of the effects of hepatocyte transplantation on rats with acute liver failure
2. Hepatocyte transplantation in rats with decompensated cirrhosis
3. Therapeutic liver repopulation for the treatment of metabolic liver diseases
4. Liver repopulation with hepatocyte transplantation: New avenues for gene and cell therapy
5. Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes
6. Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events
7. FasL expression on splenocytes and its correlation with hepatocytic apoptosis during intrasplenically allogeneic hepatocyte transplantation
8. Hepatocyte transplantation for the treatment of human disease
9. Apoptosis and pathogenesis of viral hepatitis C an update
10. Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac
11. Apoptosis and alcoholic liver disease
12. Apoptosis as a mechanism of cell death in liver allograft rejection
13. Hepatic failure and liver cell damage in acute Wilson disease involve CD95 (APO-I/Fas) mediated apoptosis
14. - hepatocytes
15. The Fas death factor
16. Granzymes: Exogenous proteinases that induce target cell apoptosis
17. Critical role of Fas/Fas ligand interaction in CD28-independent pathway of allogeneic murine hepatocyte rejection
18. Expression of the cytotoxic T cell mediator granzyme B during liver allograft rejection
19. Deciphering the apoptotic pathway: All roads lead to death
20. Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis
21. Bcl-2 family: Life-or-death switch
22. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation
23. Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses
24. Role of the bcl-2/bax pathway in hepatocyte apoptosis during acute rejection after rat liver transplantation
25. Expression of bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
26. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic bcl-2 gene
27. Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection
28. Genetic modification of liver grafts with an adenoviral vector encoding the bcl-2 gene improves organ preservation
29. Human adenovirus vectors for gene transfer into mammalian cells
30. Preparation of isolated rat liver cells
31. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ
32. Proliferative response of hepatocytes transplanted into spleen or solid support
33. Observations on the fine structure of long-survived isolated hepatocytes inoculated into rat spleen
34. Functional assessment of hepatocytes inoculated into rat spleen
35. The cytokinetic behavior of donor hepatocytes after syngeneic hepatocyte transplantation into the spleen
36. Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes
37. The apoptosis cascade morphological and immunohistochemical methods for its visualization
38. Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin
39. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice
40. Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction
41. Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell-mediated killing
42. Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis
43. Mitochondria-dependent and independent regulation of granzyme B-induced apoptosis
44. Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and fas-mediated cell death does not involve DAXX, RIP, or RAIDD
45. A rat model of monitoring liver allograft rejection
46. Hepatocyte transplantation: "Only the strong survive"
47. Different programs of activation-induced cell death are triggered in mature activated CTL by immunogenic and partially agonistic peptide ligands