Aldehyde dehydrogenase: Maintaining critical active site geometry at motif 8 in the class 3 enzyme

European Journal of Biochemistry

Volumn 268, Issue 3, 2001, Pages 722-726

  Hempel, John ^a   Kuo, Ingrid ^a   Perozich, John ^a,e   Wang, Bi Cheng ^b   Lindahl, Ronald ^c   Nicholas, Hugh ^d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b University of Georgia ^*  (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

^d CARNEGIE MELLON UNIVERSITY   (United States)

^e FRANCISCAN UNIVERSITY OF STEUBENVILLE   (United States)

Author keywords

Aldehyde dehydrogenase; Aspartic acid; Catalytic center; Glutamic acid; Phenylalanine; Site directed mutagenesis

Indexed keywords

ALDEHYDE DEHYDROGENASE; ASPARAGINE; BENZALDEHYDE; GLUTAMIC ACID; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHENYLALANINE; PROPIONALDEHYDE; PROTEIN D247N; PROTEIN E333Q; PROTEIN F335Y; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; GEOMETRY; HYDROGEN BOND; MICHAELIS CONSTANT; MUTANT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

ALDEHYDE DEHYDROGENASE; AMINO ACID MOTIFS; ANIMALS; ASPARTIC ACID; BINDING SITES; CATALYSIS; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; RATS;

EID: 0034817730     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.01926.x     Document Type: Article

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