Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans

Journal of Molecular Biology

Volumn 300, Issue 1, 2000, Pages 141-152

  Cobessi, David ^a   Tête Favier, Frédérique ^a   Marchal, Stéphane ^b   Branlant, Guy ^b   Aubry, André ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b Biopôle de l Université de Lorraine   (France)

Author keywords

ALDH X ray structure; Isotope effect; NADP flexibility; Oxyanion hole; Ternary complex

Indexed keywords

ALDEHYDE DEHYDROGENASE; APOENZYME; CARBONYL DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HOLOENZYME; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGEN; SULFATE; THIOL DERIVATIVE;

ACYLATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEACYLATION; ENZYME MECHANISM; ENZYME STRUCTURE; NONHUMAN; PH; PKA; PRIORITY JOURNAL; STREPTOCOCCUS MUTANS;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS MUTANS;

EID: 0034733390     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3824     Document Type: Article

References (25)

1. The nicotinamide dinucleotide binding motif: A comparison of nucleotide binding proteins
2. The Protein Data Bank: A computer-based archive-file for macromolecular structures
3. Sequence, expression, and function of the gene for the non phosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans
4. The R(free) value: A novel statistical quantity for assessing the accuracy of crystal structures
5. NADP-dependent enzymes. I: Conserved stereochemistry of cofactor binding
6. Apo and holo crystal structures of a NADP-dependent aldehyde dehydrogenase from Streptococcus mutans
7. The nicotinamide subsite of glyceraldehyde-3-phosphate dehydrogenase studied by site-directed mutagenesis
8. Structure of betaine aldehyde dehydrogenase at 2.1 Å resolution
9. Where freedom is given, liberties are taken
10. MOLSCRPIT: A program to produce both detailed and schematic plots of protein structures
11. The structure of retinal dehydrogenase type II at 2.7 Å resolution: Implications for retinal specificity
12. The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold
13. Evidence for the chemical activation of essential Cys-302 upon cofactor binding to nonphosphorylating glyceraldehyde 3-phosphate dehydrogenase from Streptococcus mutans
14. The role of Glu268 in the catalytic mechanism of non-phosphorylating glyceraldehyde dehydrogenase from Streptococcus mutans
15. Raster3D version 2.4 - A program for photo-realistic molecular graphics
16. Sheep liver cytosolic aldehyde dehydrogenase: The structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases
17. AMoRe: An automated package for molecular replacement
18. Processing of X-ray diffraction data collected in oscillation mode
19. Relationships within the aidehyde dehydrogenase extended family
20. X-ray crystallographic structure of a papain-leupeptin complex
21. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion
22. Prediction of the occurrence of the ADP binding βαβ-fold in proteins, using an amino acid sequence fingerprint