Intestinal protection by lafutidine, a histamine H2-receptor antagonist, against indomethacin-induced damage in rats - Role of endogenous nitric oxide

Medical Science Monitor

Volumn 7, Issue 5, 2001, Pages 869-877

  Tanaka, Akiko ^a   Mizoguchi, Hiroyuki ^a   Hase, Shoko ^a   Miyazawa, Tohru ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

A histamine H2 receptor antagonist; Lafutidine; Nitric oxide; Rat; Small intestine indomethacin induced damage

Indexed keywords

AMINOGUANIDINE; ARGININE; CAPSAICIN; HISTAMINE H2 RECEPTOR ANTAGONIST; INDOMETACIN; LAFUTIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENTEROBACTER; INTESTINE ULCER; MALE; MUCUS SECRETION; NONHUMAN; PROTECTION; RAT; SMALL INTESTINE MUCOSA;

ACETAMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; ARGININE; BACTERIAL TRANSLOCATION; CAPSAICIN; ENTEROBACTERIACEAE; ENZYME INHIBITORS; GUANIDINES; HISTAMINE H2 ANTAGONISTS; INDOMETHACIN; INTESTINE, SMALL; MALE; MUCUS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRO COMPOUNDS; PIPERIDINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; ULCER;

EID: 0034817232     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Effects of FRG-8813, a new-type histamine H2 receptor antagonist, on various experimental gastric and duodenal lesions in rats
2. Gastric antisecretory effect of FRG-8813, a new histamine H2 receptor antagonist, in rats and dogs
3. 2-receptor antagonist, in rats
4. Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: Relation to capsaicin-sensitive sensory neurons
5. Resistance of germ-free rats to indomethacin-induced intestinal inflammation
6. Indomethacin induced intestinal inflammation
7. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat
8. Indomethacin-increased gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat
9. Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin
10. Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats
11. Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats
12. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
13. Neural emergency system in the stomach
14. Role of calcitonin of gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat
15. Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced intestinal lesions in rats
16. Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum
17. Correlation of quantitave changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats
18. Colorimetric method for determination of sugars and related substances
19. E type prostaglandin inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors: A study using rats and knockout mice
20. Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion
21. Protection by constitutively formed nitric oxide of intestinal damage induced by indomethacin in rats
22. Nitric oxide donors increase mucus gel thickness in rat stomach
23. Effect of ecabet, a novel locally-acting antiulcer drug, on epithelial restitution following injury by hypertonic NaCl in bullfrog stomach in vitro
24. Role of nitric oxide in restitution of injured guinea pig gastric mucosa in vitro
25. Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases
26. Distribution and characterization of calcitonin gene-related peptide immunore activity in the digestive system of normal and capsaicin-treated rats
27. The capsaicin receptor: A heat-activated ion channel in the pain pathway