Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats

European Journal of Pharmacology

Volumn 344, Issue 2-3, 1998, Pages 191-195

  László, Ferenc ^a   Whittle, Brendan J R ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Indomethacin; Inflammation, intestinal; N(G) Nitro L arginine methyl ester (L NAME); Nitric oxide (NO); PAF (platelet activating factor); Plasma leakage; WEB 2086

Indexed keywords

APAFANT; ARGININE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; ENTERITIS; ILEUM; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ENTERITIS; ILEUM; INDOMETHACIN; JEJUNUM; MALE; NITRIC OXIDE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR;

EID: 0344653614     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01599-9     Document Type: Article

References (18)

1. Arndt, H., Russel, J.B., Kurose, I., Kubes, P., Granger, D.N., 1993. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology 105, 675-680.
2. Bjarnason, I., Zanelli, G., Smith, T., Prouse, P., Williams, P., Smethurst, P., Delacey, G., Gumpel, M.J., Levi, A.J., 1987. Nonsteroidal anti-inflammatory drug-induced intestinal inflammation in humans. Gastroenterology 93, 480-489.
3. Boughton-Smith, N.K., Deakin, A.M., Whittle, B.J.R., 1992. Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. Agents Actions 35, C3-C9, (Special Conference Issue).
4. Caplan, M.S., Hedlund, E., Hill, N., MacKendrick, W., 1994. The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Gastroenterology 106, 346-352.
5. Casals-Stanzel, J., 1987. Protective effect of WEB 2086, a novel antagonist of platelet-activating factor, in endotoxin shock. Eur. J. Pharmacol. 135, 117-122.
6. Filep, J.G., Földes-Filep, É., 1993. Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation in the conscious rat. Br. J. Pharmacol. 110, 1347-1352.
7. Hutcheson, I.R., Whittle, B.J.R., Boughton-Smith, N.K., 1990. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br. J. Pharmacol. 101, 815-820.
8. Kiss, J., Lamarque, D., Delchier, J.C., Whittle, B.J.R., 1996. Differential time-dependent effects of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats. Gastroenterology 110, A938.
9. Kubes, P., Suzuki, M., Granger, D.N., 1991. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88, 4651-4655.
10. László, F., Whittle, B.J.R., Moncada, S., 1994a. Time-dependent enhancement and inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br. J. Pharmacol. 111, 1309-1315.
11. László, F., Whittle, B.J.R., Moncada, S., 1994b. Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia. Br. J. Pharmacol. 113, 1131-1136.
12. Rees, D.D., Palmer, R.M.J., Moncada, S., 1990. Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br. J. Pharmacol. 101, 746-752.
13. Santucci, L., Fiorucci, S., Giansanti, M., Brunori, P.M., Di Matteo, F., Morelli, A., 1994. Pentoxifylline prevents indomethacin-induced acute gastric mucosal damage in rats: Role of tumor necrosis factor alpha. Gut 35, 909-915.
14. Somogyi, A., Kovacs, K., Selye, H., 1969. Jejunal ulcers produced by indomethacin. J. Pharm. Pharmacol. 21, 122-123.
15. Whittle, B.J.R., 1981. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80, 94-98.
16. Whittle, B.J.R., 1994. Nitric oxide in gastrointestinal physiology and pathology. In: Johnson, L.R. (Ed.), Physiology of the Gastrointestinal Tract, 3rd ed. Raven Press, New York, pp. 267-294.
17. Whittle, B.J.R., Laszlo, F., Evans, S.M., Moncada, S., 1995. Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin. Br. J. Pharmacol. 116, 2286-2290.
18. Yamada, T., Deitch, E., Specian, R.D., Perry, M.A., Sartor, R.B., Grisham, M.B., 1993. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 17, 641-662.