Protection by constitutively formed nitric oxide of intestinal damage induced by indomethacin in rats

Journal of Physiology Paris

Volumn 95, Issue 1-6, 2001, Pages 35-41

  Tanaka, Akiko ^a   Mizoguchi, Hiroyuki ^a   Kunikata, Tomonori ^a   Miyazawa, Tohru ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

cNOS; Enterobacteria; Enteropooling; Indomethacin; Intestinal lesion; Mucus secretion motility; Nitric oxide; Rat

Indexed keywords

4 ETHYL 2 HYDROXYIMINO 5 NITRO 3 HEXENAMIDE; ARGININE; ETHYL 2 (HYDROXYIMINO) 5 NITRO 3 HEXANAMINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; URETHAN;

ANIMAL MODEL; ANIMAL TISSUE; BACTERIAL TRANSLOCATION; CONFERENCE PAPER; CONTROLLED STUDY; DIGESTIVE SYSTEM ULCER; DRUG INDUCED DISEASE; ENTEROBACTERIACEAE; GASTROINTESTINAL HEMORRHAGE; INTESTINE MOTILITY; INTESTINE ULCER; MALE; NONHUMAN; RAT; SMALL INTESTINE MUCOSA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIAL TRANSLOCATION; BODY FLUIDS; CYTOPROTECTION; ENZYME INHIBITORS; GASTROINTESTINAL MOTILITY; INDOMETHACIN; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MUCUS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRO COMPOUNDS; PEPTIC ULCER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034751068     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(01)00007-9     Document Type: Conference Paper

References (22)

1. Early histological features of small intestinal injury induced by indomethacin
2. Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
3. Correlation of quantitave changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats
4. Nonsteroidal anit-inflammatory drug-induced intestinal inflammation in humans
5. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
6. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo
7. Indomethacin induced intestinal inflammation
8. Effect of ecabet, a novel locally-acting antiulcer drug, on epithelial restitution following injury by hypertonic NaCl in bullfrog stomach in vitro
9. Aminoguanidine selectively inhibits inducible nitric oxide synthase
10. Spontaneous nitric oxide release accounts for the potent pharmacological action of FK 409
11. Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats
12. E type prostaglandin inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors: A study using rats and knockout mice
13. Role of nitric oxide in maintaining the mucosal integrity and in inflammatory gastrointestinal diseases
14. Time-dependent enhancement and inhibition of endotoxin-induced vascular injugy in rat intestine by nitric oxide synthase inhibitors
15. Enteropooling assay: A test for diarrhea produced by prostaglandins
16. Resistance of germ-free rats to indomethacin-induced intestinal inflammation
17. Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats
18. Indomethacin-increased gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat
19. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in rat
20. Nitric oxide in gastrointestinal physiology and pathology
21. Inducible nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin
22. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin