메뉴 건너뛰기




Volumn 10, Issue 9, 1999, Pages 621-628

Ras- and mitogen-activated protein kinase kinase-dependent and - independent pathways in p21(Cip2/Waf1) induction by fibroblast growth factor- 2, platelet-derived growth factor, and transforming growth factor-β1

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR B; PROTEIN P21; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0032880860     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (54)
  • 1
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signalling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C. J. Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80: 179-185, 1995.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 2
    • 0026483357 scopus 로고
    • Function of Ras as a molecular switch in signal transduction
    • Satoh, T., Nakafuku, M., and Kaziro, Y. Function of Ras as a molecular switch in signal transduction. J. Biol. Chem., 267: 24149-24152, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24149-24152
    • Satoh, T.1    Nakafuku, M.2    Kaziro, Y.3
  • 3
    • 0021970413 scopus 로고
    • Requirement for Ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
    • Mulcahy, L. S., Smith, M. R., and Stacey, D. W. Requirement for Ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature (Lond.), 313: 241-243, 1985.
    • (1985) Nature (Lond.) , vol.313 , pp. 241-243
    • Mulcahy, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 4
    • 0026336517 scopus 로고
    • Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes
    • Stacey, D. W., Roudebush, M., Day, R., Mosser, S. D., Gibbs, J. B., and Feig, L. A. Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. Oncogene, 6: 2297-2304, 1991.
    • (1991) Oncogene , vol.6 , pp. 2297-2304
    • Stacey, D.W.1    Roudebush, M.2    Day, R.3    Mosser, S.D.4    Gibbs, J.B.5    Feig, L.A.6
  • 5
    • 0026578026 scopus 로고
    • Growth factor signaling: Where is the specificity?
    • Chao, M. V. Growth factor signaling: where is the specificity? Cell, 68: 995-997, 1992.
    • (1992) Cell , vol.68 , pp. 995-997
    • Chao, M.V.1
  • 6
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic Ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. Oncogenic Ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88: 593-602, 1997.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 8
    • 0030933277 scopus 로고    scopus 로고
    • Oncoprotein networks
    • Hunter, T. Oncoprotein networks. Cell, 88: 333-346, 1997.
    • (1997) Cell , vol.88 , pp. 333-346
    • Hunter, T.1
  • 9
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells
    • Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells. Cell, 77: 841-852, 1994.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 10
    • 0026534571 scopus 로고
    • Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
    • Thomas, S. M., DeMarco, M., D'Arcangelo, G., Halegoua, S., and Brugge, J. S. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell, 68: 1031-1040, 1992.
    • (1992) Cell , vol.68 , pp. 1031-1040
    • Thomas, S.M.1    DeMarco, M.2    D'Arcangelo, G.3    Halegoua, S.4    Brugge, J.S.5
  • 11
    • 0026523559 scopus 로고
    • Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1 and RSK
    • Wood, K. W., Samecki, C., Roberts, T. M., and Blenis, J. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1 and RSK. Cell, 68: 1041-1050, 1992.
    • (1992) Cell , vol.68 , pp. 1041-1050
    • Wood, K.W.1    Samecki, C.2    Roberts, T.M.3    Blenis, J.4
  • 12
    • 0029892754 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires ras and the activation of mitogen-activated protein kinase
    • Gardner, A. M., and Johnson, G. L. Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires ras and the activation of mitogen-activated protein kinase. J. Biol. Chem., 271: 14560-14566, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14560-14566
    • Gardner, A.M.1    Johnson, G.L.2
  • 15
    • 0029788015 scopus 로고    scopus 로고
    • Altered transforming growth factor β signaling in epithelial cells when Ras activation is blocked
    • Hartsough, M. T., Frey, R. S., Zipfel, P. A., Buard, A., Cook, S. J., McCormick, F., and Mulder, K. M. Altered transforming growth factor β signaling in epithelial cells when Ras activation is blocked. J. Biol. Chem., 271: 22368-22375, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22368-22375
    • Hartsough, M.T.1    Frey, R.S.2    Zipfel, P.A.3    Buard, A.4    Cook, S.J.5    McCormick, F.6    Mulder, K.M.7
  • 17
    • 0030022174 scopus 로고    scopus 로고
    • Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation
    • Urano, T., Emkey, R., and Feig, L. A. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J., 15: 810-816, 1996.
    • (1996) EMBO J. , vol.15 , pp. 810-816
    • Urano, T.1    Emkey, R.2    Feig, L.A.3
  • 20
    • 0028982948 scopus 로고
    • Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation
    • Hawes, B. E., van Biesen, T., Koch, W. J., Luttrell, L. M., and Lefkowitz, R. J. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J. Biol. Chem., 270: 17148-17153, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17148-17153
    • Hawes, B.E.1    Van Biesen, T.2    Koch, W.J.3    Luttrell, L.M.4    Lefkowitz, R.J.5
  • 21
    • 0029789967 scopus 로고    scopus 로고
    • Protein kinase C delta activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
    • Ueda, Y., Hirai, S-I., Osada, S-I., Suzuki, A., Mizuno, K., and Ohno, S. Protein kinase C delta activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem., 271; 23512-23519, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23512-23519
    • Ueda, Y.1    Hirai, S.-I.2    Osada, S.-I.3    Suzuki, A.4    Mizuno, K.5    Ohno, S.6
  • 23
  • 24
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 26
    • 0033559264 scopus 로고    scopus 로고
    • The p21Cip1 and p27Kip1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng, M., Olivier, P., Diehl, J. A., Fera, M., Roussel, M. F., Roberts, J. M., and Sherr, C. J. The p21Cip1 and p27Kip1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J., 18: 1571-1583, 1999.
    • (1999) EMBO J. , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fera, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 27
    • 0028963841 scopus 로고
    • p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
    • Macleod, K. F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B., and Jacks, T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev., 9: 935-944, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 935-944
    • Macleod, K.F.1    Sherry, N.2    Hannon, G.3    Beach, D.4    Tokino, T.5    Kinzler, K.6    Vogelstein, B.7    Jacks, T.8
  • 28
    • 0030758522 scopus 로고    scopus 로고
    • Nerve growth factor induces transcription of the p21WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor
    • Yan, G-Z., and Ziff, E. B. Nerve growth factor induces transcription of the p21WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J. Neurosci., 17: 6122-6132, 1997.
    • (1997) J. Neurosci. , vol.17 , pp. 6122-6132
    • Yan, G.-Z.1    Ziff, E.B.2
  • 29
    • 0031028381 scopus 로고    scopus 로고
    • Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc
    • Pumiglia, K. M., and Decker, S. J. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA, 94: 448-452, 1997.
    • (1997) Natl. Acad. Sci. USA , vol.94 , pp. 448-452
    • Pumiglia, K.M.1    Decker, S.J.2
  • 30
    • 0028980376 scopus 로고
    • Prolonged induction of p21Cip1/Waf1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition
    • Fan, Z., Lu, Y., Wu, X., DeBlasio, A., Koff, A., and Mendelsohn, J. Prolonged induction of p21Cip1/Waf1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J. Cell Biol., 131: 235-242, 1995.
    • (1995) J. Cell Biol. , vol.131 , pp. 235-242
    • Fan, Z.1    Lu, Y.2    Wu, X.3    DeBlasio, A.4    Koff, A.5    Mendelsohn, J.6
  • 31
    • 0028829465 scopus 로고
    • Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter
    • Datto, M. B., Yu, Y., and Wang, X-F. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter. J. Biol. Chem., 270: 28623-28628, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28623-28628
    • Datto, M.B.1    Yu, Y.2    Wang, X.-F.3
  • 33
    • 0032554765 scopus 로고    scopus 로고
    • FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells
    • Johnson, M. R., Valentine, C., Basilico, C., and Mansukhani, A. FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells. Oncogene, 16: 2647-2656, 1998.
    • (1998) Oncogene , vol.16 , pp. 2647-2656
    • Johnson, M.R.1    Valentine, C.2    Basilico, C.3    Mansukhani, A.4
  • 34
    • 0030701842 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p21Cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells
    • Zezula, J., Sexl, V., Hutter, C., Karel, A., Schütz, W., and Freissmuth, M. The cyclin-dependent kinase inhibitor p21Cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells. J. Biol. Chem., 272: 29967-29974, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29967-29974
    • Zezula, J.1    Sexl, V.2    Hutter, C.3    Karel, A.4    Schütz, W.5    Freissmuth, M.6
  • 35
    • 0033523778 scopus 로고    scopus 로고
    • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites
    • in press
    • Kivinen, L., Tsubari, M., Haapajärvi, T., Datto, M. B., Wang, X-F., and Laiho, M. Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. Oncogene, in press, 1999.
    • (1999) Oncogene
    • Kivinen, L.1    Tsubari, M.2    Haapajärvi, T.3    Datto, M.B.4    Wang, X.-F.5    Laiho, M.6
  • 36
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf-activity with arrest mediated by p21Cip1
    • Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees, E., and McMahon, M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf-activity with arrest mediated by p21Cip1. Mol. Cell. Biol., 17: 5598-5611, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 37
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing, A., Wiseman, B., Lloyd, A., and Land, H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol., 17: 5588-5597, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.3    Land, H.4
  • 38
    • 0029664395 scopus 로고    scopus 로고
    • Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway
    • Liu, Y., Martindale, J. L., Gorospe, M., and Holbrook, N. J. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res., 56: 31-35, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 31-35
    • Liu, Y.1    Martindale, J.L.2    Gorospe, M.3    Holbrook, N.J.4
  • 39
    • 0032537819 scopus 로고    scopus 로고
    • Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
    • Olson, M. F., Paterson, H. F., and Marshall, C. J. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature (Lond.), 394: 295-299, 1998.
    • (1998) Nature (Lond.) , vol.394 , pp. 295-299
    • Olson, M.F.1    Paterson, H.F.2    Marshall, C.J.3
  • 40
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak, K., Lee, M. H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., and Massagué, J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78: 59-66, 1994.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massagué, J.7
  • 41
    • 0032499802 scopus 로고    scopus 로고
    • Blockade in TGF β 3 upregulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells
    • Yue, J., Buard, A., and Mulder, K. M. Blockade in TGF β 3 upregulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells. Oncogene, 17: 47-55, 1998.
    • (1998) Oncogene , vol.17 , pp. 47-55
    • Yue, J.1    Buard, A.2    Mulder, K.M.3
  • 42
    • 0030692016 scopus 로고    scopus 로고
    • Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells
    • Schweppe, R. E., Frazer-Abel, A. A., Gutierrez-Hartmann, A., and Bradford, A. P. Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells. J. Biol. Chem., 272: 30852-30859, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30852-30859
    • Schweppe, R.E.1    Frazer-Abel, A.A.2    Gutierrez-Hartmann, A.3    Bradford, A.P.4
  • 43
    • 0029790656 scopus 로고    scopus 로고
    • FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
    • Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., and Comb, M. J. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J., 15: 4629-4642, 1996.
    • (1996) EMBO J. , vol.15 , pp. 4629-4642
    • Tan, Y.1    Rouse, J.2    Zhang, A.3    Cariati, S.4    Cohen, P.5    Comb, M.J.6
  • 44
    • 0028239047 scopus 로고
    • Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts
    • Lubinus, M., Meier, K. E., Smith, E. A., Gause, K. C., LeRoy, E. C., and Trojanowska, M. Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts. J. Biol. Chem., 269: 9822-9825, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9822-9825
    • Lubinus, M.1    Meier, K.E.2    Smith, E.A.3    Gause, K.C.4    LeRoy, E.C.5    Trojanowska, M.6
  • 45
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Reynisdottir, I., Polyak, K., lavarone, A., and Massagué, J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9: 1831-1845, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Lavarone, A.3    Massagué, J.4
  • 46
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270: 27489-27494, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 47
    • 0031058607 scopus 로고    scopus 로고
    • Transforming growth factor-β induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells
    • Reimann, T., Hempel, U., Krautwald, S., Axmann, A., Scheibe, R., Seidel, D., and Wenzel, K-W. Transforming growth factor-β induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett., 403: 57-60, 1997.
    • (1997) FEBS Lett. , vol.403 , pp. 57-60
    • Reimann, T.1    Hempel, U.2    Krautwald, S.3    Axmann, A.4    Scheibe, R.5    Seidel, D.6    Wenzel, K.-W.7
  • 48
    • 0029616117 scopus 로고
    • Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation
    • Chatani, Y., Tanimura, S., Miyoshi, N., Hattori, A., Sato, M., and Kohno, M. Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation. J. Biol. Chem., 270: 30686-30692, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 30686-30692
    • Chatani, Y.1    Tanimura, S.2    Miyoshi, N.3    Hattori, A.4    Sato, M.5    Kohno, M.6
  • 49
    • 0026612306 scopus 로고
    • Activation of p21 ras by transforming growth factor β in epithelial cells
    • Mulder, K. M., and Morris, S. L. Activation of p21 ras by transforming growth factor β in epithelial cells. J. Biol. Chem., 267: 5029-5031, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5029-5031
    • Mulder, K.M.1    Morris, S.L.2
  • 50
    • 0028937610 scopus 로고
    • Transforming growth factor β activation of p44mapk in proliferating cultures of epithelial cells
    • Hartsough, M. T., and Mulder, K. M. Transforming growth factor β activation of p44mapk in proliferating cultures of epithelial cells. J. Biol. Chem., 270: 7117-7124, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7117-7124
    • Hartsough, M.T.1    Mulder, K.M.2
  • 51
    • 0031909865 scopus 로고    scopus 로고
    • p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system
    • Gorospe, M., Wang, X., and Holbrook, N. J. p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system. Mol. Cell. Biol., 18: 1400-1407, 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1400-1407
    • Gorospe, M.1    Wang, X.2    Holbrook, N.J.3
  • 52
    • 0029658129 scopus 로고    scopus 로고
    • p21ras-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanisms
    • Kivinen, L., Tiihonen, E., Haapajärvi, T., and Laiho, M. p21ras-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanisms. Cell Growth Differ., 7: 1705-1712, 1996.
    • (1996) Cell Growth Differ. , vol.7 , pp. 1705-1712
    • Kivinen, L.1    Tiihonen, E.2    Haapajärvi, T.3    Laiho, M.4
  • 53
    • 0027317086 scopus 로고
    • Human retinoblastoma gene product prevents c-Ha-ras oncogene mediated cellular transformation of mouse fibroblasts
    • Kivinen, L., Pitkänen, K., and Laiho, M. Human retinoblastoma gene product prevents c-Ha-ras oncogene mediated cellular transformation of mouse fibroblasts. Oncogene, 8: 2703-2711, 1993.
    • (1993) Oncogene , vol.8 , pp. 2703-2711
    • Kivinen, L.1    Pitkänen, K.2    Laiho, M.3
  • 54
    • 0029133264 scopus 로고
    • Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation
    • Haapajärvi, T., Kivinen, L., Pitkänen, K., and Laiho, M. Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation. Oncogene, 11: 151-159, 1995.
    • (1995) Oncogene , vol.11 , pp. 151-159
    • Haapajärvi, T.1    Kivinen, L.2    Pitkänen, K.3    Laiho, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.