Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of met receptor and protein kinase transducers in human hepatoma cells HepG2

Experimental Cell Research

Volumn 256, Issue 1, 2000, Pages 272-281

  Tacchini, Lorenza ^a   Dansi, Paola ^a   Matteucci, Emanuela ^a   Desiderio, Maria Alfonsina ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Hepatocyte growth factor; Met; Protein kinase inhibitors; Transcription factors; Transduction pathways

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DIMER; DISULFIDE; DNA; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE C; SCATTER FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; TYROSINE KINASE RECEPTOR;

ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PHOSPHORYLATION; PRIORITY JOURNAL;

EID: 0034630462     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4824     Document Type: Article

References (60)

1. Zarnegar R., Michalopoulos G. K. The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis. J. Cell Biol. 129:1995;1177-1180.
2. Desiderio M. A., Pogliaghi G., Dansi P. Hepatocyte-growth factor induced expression of ornithine decarboxylase, c-met e c-myc is differently affected by protein kinase inhibitors in human hepatoma cells HepG2. Exp. Cell Res. 242:1998;401-409.
3. Shiota G., Rohads D. B., Wang T. C., Nakamura T., Schmidt E. V. Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc. Natl. Acad. Sci. USA. 89:1992;373-377.
4. Tajima H., Matsumoto K., Nakamura T. Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines. FEBS Lett. 291:1991;229-232.
5. Giordano S., Ponzetto C., Di Renzo M. F., Cooper C. S., Comoglio P. M. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature. 339:1989;155-156.
6. Comoglio P. M., Vigna E. Structure and functions of the HGF receptor (c-Met). Jirtle R. L. Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms. 1995;51-70 Academic Press, San Diego.
7. Gandino L., Di Renzo M. F., Giordano S., Bussolino F., Comoglio P. M. Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein. Oncogene. 5:1990;721-725.
8. Maggiora P., Gambarotta G., Olivero M., Giordano S., Di Renzo M. F., Comoglio P. M. Control of invasive growth by the HGF receptor family. J. Cell. Physiol. 173:1997;183-186.
9. D'Errico A., Fiorentino M., Ponzetto A., Daikuhara Y., Tsubouchi H., Brechot C., Scoazec J.-Y., Grigioni W. F. Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: Its specific receptor c-met does. Hepatology. 24:1996;60-64.
10. Grigioni W. F., Fiorentino M., D'Errico A., Ponzetto A., Crepaldi T., Prat M., Comoglio P. M. Overexpression of c-met protooncogene product and rised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions. Hepatology. 21:1995;1543-1546.
11. Ueki T., Fujimoto J., Suzuki T., Yamamoto H., Okamoto E. Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma. Hepatology. 25:1997;619-623.
12. Desiderio M. A., Limonta D. M., Bardella L. Expression patterns of ornithine decarboxylase and c-met in growing Yoshida AH-130 hepatoma. Cancer Lett. 87:1994;33-38.
13. Ivan M., Bond J. A., Prat M., Comoglio P. M., Wynford-Thomas D. Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene. 14:1997;2417-2423.
14. Ponzetto C., Giordano S., Peverali F., Della Valle G., Abate M. L., Vaula G., Comoglio P. M. c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene. 6:1991;553-559.
15. Seol D.-W., Zarnegar R. Structural and functional characterization of the mouse c-met proto-oncogene (hepatocyte growth factor receptor) promoter. Biochim. Biophys. Acta. 1395:1998;252-258.
16. Boccaccio C., Gaudino G., Gambarotta G., Galimi F., Comoglio P. M. Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J. Biol. Chem. 269:1994;12846-12851.
17. Gambarotta G., Boccaccio C., Giordano S., Andò M., Stella M. C., Comoglio P. M. ETS up-regulates MET transcription. Oncogene. 13:1996;1911-1917.
18. Auvinen M., Paasinen A., Andersson L. C., Hölttä E. Ornithine decarboxylase activity is critical for cell transformation. Nature. 360:1992;355-358.
19. Pawson T., Scott J. D. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:1997;2075-2080.
20. La Rosa F. A., Pierce J. W., Sonenshein G. E. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Mol. Cell. Biol. 14:1994;1039-1044.
21. Packham G., Cleveland J. L. c-Myc and apoptosis. Biochim. Biophys. Acta. 1242:1995;11-28.
22. Dang C. V. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 19:1999;1-11.
23. Malarkey K., Belham C. M., Paul A., Graham A., McLees A., Scott P. H., Plevin R. The regulation of tyrosine kinase signaling pathways by growth factor and G-protein-coupled receptors. Biochem. J. 309:1995;361-375.
24. May M. J., Ghosh S. Signal transduction through NF-κB. Immunol. Today. 19:1998;80-88.
25. 1 integrins. Blood. 89:1997;990-1000.
26. Muroi M., Suzuki T. Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774. Cell. Signal. 5:1993;289-298.
27. Sommer A., Bousset K., Kremmer E., Austen M., Lüscher B. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. J. Biol. Chem. 273:1998;6632-6642.
28. Tacchini L., Radice L., Bernelli-Zazzera A. Differential activation of some transcription factors during rat liver ischemia, reperfusion, and heat shock. J. Cell Physiol. 180:1999;255-262.
29. Grimm S., Baeuerle P. A. The inducible transcription factor NF-kappa B: Structure-function relationship of its protein subunits. Biochem. J. 290:1993;297-308.
30. Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P., Buettner R., Eilers M. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J. 14:1995;1508-1519.
31. Jehn B., Costello E., Marti A., Keon N., Deane R., Li F., Friis R. R., Burri P. H., Martin F., Jaggi R. Overexpression of Mos, Ras, Src, and Fos inhibits mouse mammary epithelial cell differentiation. Mol. Cell. Biol. 12:1992;3890-3902.
32. Chomczynski P., Sacchi N. Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
33. Zarnegar R., DeFrances M. C., Kost D. P., Lindroos P., Michalopoulos G. K. Expression of hepatocyte growth factor mRNA in regenerating rat liver after partial hepatectomy. Biochem. Biophys. Res. Commun. 177:1991;559-565.
34. Maier J. A. M., Mariotti M., Comoglio P. M., Soria M. R. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene. 13:1996;1009-1015.
35. Rubin J. S., Chan A. M.-L., Bottaro D. P., Burgess W. H., Taylor W. G., Cech A. C., Hirschfield D. W., Wong J., Miki T., Finch P. W., Aaronson S. A. A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc. Natl. Acad. Sci. USA. 88:1991;415-419.
36. Runge D. M., Runge D., Dorko K., Pisarov L. A., Leckel K., Kostrubsky V. E., Thomas D., Strom S. C., Michalopoulos G. K. Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes. J. Hepatol. 30:1999;265-274.
37. Zwacka R. M., Zhang Y., Zhou W., Halldorson J., Engelhardt J. F. Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor κB independently of IκB degradation. Hepatology. 28:1998;1022-1030.
38. Leask A., Byrne C., Fuchs E. Transcription factor AP2 and its role in epidermal-specific gene expression. Proc. Natl. Acad. Sci. USA. 88:1991;7948-7952.
39. Gibson A. W., Cheng T., Johnston R. N. Apoptosis induced by c-myc overexpression is dependent on growth conditions. Exp. Cell Res. 218:1995;351-358.
40. Gordge P. C., Ryves W. J. Inhibitors of protein kinase C. Cell Signal. 6:1994;871-882.
41. Jarvis W. D., Turner A. J., Povirk L. F., Traylor R. S., Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54:1994;1707-1714.
42. Day R. M., Cioce V., Breckenridge D., Castagnino P., Bottaro D. P. Differential signaling by alternative HGF isoforms through c-Met: Activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis. Oncogene. 18:1999;3399-3406.
43. FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J. Biol. Chem. 269:1994;31807-31813.
44. Shima N., Nagao M., Ogaki F., Tsuda E., Murakami A., Higashio K. Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: Cloning of its cDNA, purification and characterization of recombinant protein. Biochem. Biophys. Res. Commun. 180:1991;1151-1158.
45. Rubin J. S., Bottaro D. P., Aaronson S. A. Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim. Biophys. Acta. 1155:1993;357-371.
46. Mar P. K., Kumar A. P., Kang D.-C., Zhao B., Martinez L. A., Montgomery R. L., Anderson L., Butler A. P. Characterization of novel phorbol ester- and serum-responsive sequences of the rat ornithine decarboxylase gene promoter. Mol. Carcinog. 14:1995;240-250.
47. Rahmani M., Nadori F., Durand-Schneider A.-M., Lardeux B., Bernuau D. Hepatocyte growth factor activates the AP-1 complex: A comparison between normal and transformed rat hepatocytes. J. Hepatol. 30:1999;916-925.
48. Wernert N., Gilles F., Fafeur V., Bouali F., Raes M.-B., Pyke C., Dupressoir T., Seitz G., Vanderbunder B., Stéhelin D. Stromal expression of c-Ets1 transcription factor correlates with tumor invasion. Cancer Res. 54:1994;5683-5688.
49. Ried S., Jäger C., Jeffers M., Vande Woude G. F., Graeff H., Schmitt M., Lengyel E. Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor. J. Biol. Chem. 274:1999;16377-16386.
50. Shen B.-J., Chang C.-J., Lee H.-S., Tsai W.-H., Miau L.-H., Lee S.-C. Transcriptional induction of the agp/ebp (c/ebpβ) gene by hepatocyte growth factor. DNA Cell Biol. 16:1997;703-711.
51. Auvinen M. Cell transformation, invasion, and angiogenesis: A regulatory role of ornithine decarboxylase and polyamines. J. Natl. Cancer Inst. 89:1997;533-537.
52. Kubota S., Kiyosawa H., Nomura Y., Yamada T., Seyama Y. Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: Cellular transformation and invasion. J. Natl. Cancer Inst. 89:1997;567-571.
53. Smith M. K., Goral M. A., Wright J. H., Matrisian L. M., Morris R. J., Klein-Szanto A. J. P., Gilmour S. K. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res. 57:1997;2104-2108.
54. Rodrigues G. A., Park M., Schlessinger J. Activation of JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16:1997;2634-2645.
55. Karin M., Liu Z.-g., Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:1997;240-246.
56. Ogasawara H., Hiramoto J., Takahashi M., Shirahama K., Furasaka A., Hiyane S., Nakada T., Nagayama K., Tanaka T. Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells. Gastroenterology. 114:1998;775-781.
57. Grether-Beck S., Olaizola-Horn S., Schmitt H., Grewe M., Jahnke A., Johnson J. P., Briviba K., Sies H., Krutmann J. Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc. Natl. Acad. Sci. USA. 93:1996;14586-14591.
58. Ip Y. T., Davis R. J. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development. Curr. Opin. Cell Biol. 10:1998;205-219.
59. Webb C. P., Taylor G. A., Jeffers M., Fiscella M., Oskarsson M., Resau J. H., Vande Woude G. F. Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene. 17:1998;2019-2025.
60. Rusciano D., Lorenzoni P., Burger M. M. Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by cytosolic tyrosine phosphatase activity. J. Biol. Chem. 271:1996;20763-20769.