Ribosome-inactivating proteins: A family of plant proteins that do more than inactivate ribosomes

Critical Reviews in Plant Sciences

Volumn 20, Issue 5, 2001, Pages 395-465

  Van Damme, E J M ^a   Hao, Q ^a   Chen, Y ^a   Barre, A ^a   Vandenbussche, F ^a   Desmyter, S ^a   Rouge P ^a   Peumans, W J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Antiviral activity; DNA glycosylase AP lyase; Polynucleotide:adenosine glycosidase; RALyase; RNA N glycosylase

Indexed keywords

BIOLOGICAL FUNCTIONS; MOLECULAR EVOLUTION; PLANT DEFENSE; PLANT MICROORGANISM INTERACTION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RIBOSOME INACTIVATING PROTEIN;

EID: 0034815870     PISSN: 07352689     EISSN: None     Source Type: Journal    
DOI: 10.1080/07352689.2001.10131826     Document Type: Review

References (184)

1. Inhibition of protein synthesis in vitro by proteins from the seeds of Momordica charantia (bitter pear melon)
2. Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites
3. Ribosome-inactivating proteins from plants
4. Unexpected activity of saporins
5. Polynucleotide: Adenosine glycosidase activity of saporin-L1: Effect on DNA, RNA and poly(A)
6. Polynucleotide: Adenosine glycosidase activity of ribosome-inactivating proteins: Effect on DNA, RNA and poly(A)
7. Polynucleotide: Adenosine glycosidase activity of saporin-L1: Effect on various forms of mammalian DNA
8. Polynucleotide: Adenosine glycosidase is the sole activity of ribosome-inactivating proteins on DNA
9. Toxicity and cytotoxicity of nigrin b, a two-chain ribosome-inactivating protein from Sambucus nigra: Comparison with ricin
10. Isolation and characterization of a cDNA encoding a novel jasmonate-induced protein of barley (Hordeum vulgare L.)
11. Ebulitins: A new family of type 1 ribosome-inactivating proteins (rRNA N-glycosidases) from leaves of Sambucus ebulus L. that coexist with the type 2 ribosome-inactivating protein ebulin 1
12. Constitutive and inducible type 1 ribosome-inactivating proteins (RIPs) in elderberry (Sambucus nigra L.)
13. A simplified procedure for the purification of trichosanthin (a type 1 ribosome inactivating protein) from Trichosanthes kirilowii root tubers
14. Expression of active barley seed ribosome-inactivating protein in transgenic wheat
15. Genetic engineering of wheat for increased resistance to powdery mildew disease
16. Pokeweed antiviral protein inactivates pokeweed ribosomes: Implications for the antiviral mechanism
17. The Gal/GalNAc-specific lectin from the plant pathogenic basidiomyete Rhizoctonia solani is a member of the ricin-B family
18. Cellular and subcellular distribution of saporins, type-1 ribosome-inactivating proteins in soapwort (Saponaria officinalis L.)
19. Mutagenesis and kinetic analysis of the active site Glu177 of ricin-A chain
20. The barley 60 kDa jasmonate-induced protein (JIP60) is a novel ribosome-inactivating protein
21. Preliminary crystallographic studies of crotin II
22. The phosphatase activity of five ribosome-inactivating proteins
23. Crystallization and preliminary crystallographic study of cucurmosin, a ribosome-inactivating protein from the sarcocarp of Cucurbita moschata
24. Characterization of a new non-toxic two-chain ribosome-inactivating protein and a structurally related lectin from rhizomes of dwarf elder (Sambucus ebulus L.)
25. Enzymatic inactivation of eukaryotic ribosomes by the pokeweed antiviral protein
26. Structure and activity of an active site substitution of ricin A chain
27. The deoxyribonuclease activity attributed to ribosome-inactivating proteins is due to contamination
28. Identification of a biological inactive complex form of pokeweed antiviral protein
29. Relative toxicity of the maize endosperm ribosome-inactivating protein to insects
30. The effect of treating vires of tobacco mosaic with juice of various plants
31. RIP-JIP60 alters conformation of ribosomes in vivo
32. The jasmonate-induced 60 kDa protein of barley exhibits N-glycosidase activity in vivo
33. RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes
34. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins
35. Ribosomal RNA identity elements for ricin A-chain recognition and catalysis
36. Characterization of a saporin isoform with lower ribosome-inhibiting activity
37. Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae)
38. Crystal structure of recombinant human interleukin-1β at 2.0 Å resolution
39. Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1α, 1β, and 2γ
40. Double-site ricin B chain mutants retain galactose binding
41. Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts
42. The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting
43. Ricin toxin contains three lectin sites which contribute to its in vivo toxicity
44. Crystal structure of Streptomyces olivaceoviridis E-86 β-xylanase containing xylan-binding domain
45. Effects of ribosome-inactivating proteins on insect development: Differences between Lepidoptera and Coleoptera
46. Isolation and partial characterization of nigrin b, a non-toxic novel type 2 ribosome-inactivating protein from the bark of Sambucus nigra L.
47. Ebulin 1, a nontoxic novel type 2 ribosome-inactivating protein from Sambucus ebulus L. leaves
48. RIP for viruses
49. Expression of the ribosome-inactivating protein JIP60 from barley in transgenic tobacco leads to an abnormal phenotype and alterations on the level of translation
50. Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes
51. Structure of interleukin-1α at 2.7 Å resolution
52. Sambucus nigra agglutinin is located in protein bodies in the phloem parenchyma of bark
53. Crystal structures of the complexes of trichosanthin with four substrate analogs and catalytic mechanism of RNA N-glycosidase
54. Nucleotide sequence of a genomic gene encoding tritin, a ribosome-inactivating protein from Triticum aestivum
55. Microenvironment of cysteine 242 in type-1 ribosome-inactivating protein from Iris
56. Iris (Iris hollandica var. Professor Blaauw) bulbs express type-1 and type-2 ribosome-inactivating proteins with unusual properties
57. The structure and function of ribosome-inactivating proteins
58. Identification of the tryptophan residue located at the low-affinity saccharide binding site of ricin D
59. Intracellular-localization of jasmonate-induced proteins in barley leaves
60. Ricin RCA60: Evidence of its phospholipase activity
61. Maize ribosome-inactivating protein (b-32). Homologs in related species, effects on maize ribosomes, and modulation of activity by pro-peptide deletions
62. Novel galactose-binding proteins in Annelida. Characterization of 29-kDa tandem repeat-type lectins from the earthworm Lumbricus terrestris
63. Resistance to geminivirus infection by virus-induced expression of dianthin in transgenic plants
64. Transactivation of dianthin transgene expression by African cassava mosaic virus AC2
65. X-ray structure of gelonin at 1.8 Å resolution
66. Seasonal variations in different forms of pokeweed antiviral protein, a potent inactivator of ribosomes
67. Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins
68. Pokeweed antiviral protein accesses ribosomes by binding to L3
69. A novel mechanism for inhibition of translation by pokeweed antiviral protein: Depurination of the capped RNA template
70. Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia
71. Enhanced quantitative resistance against fungal disease by combinatorial expression of different barley antifungal proteins in transgenic tobacco
72. Structure of Ricin A-chain at 2.5 Å
73. Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography
74. Molecular and genetic analysis of transgenic rice plants expressing the maize ribosome-inactivating protein b-32 and the herbicide resistance bar gene
75. Structures of sugar chains of ricin D
76. Molscript: A program to produce both detailed and schematic plots of protein structures
77. Crystal structure of mistletoe lectin I from Viscum album
78. Characterization of the lectin from the bulbs of Eranthis hyemalis (winter aconite) as an inhibitor of protein synthesis
79. Interactions between tobacco mosaic virus, pokeweed antiviral proteins, and tobacco cell wall
80. X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs
81. X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA
82. Use of trichosanthin to reduce infection by turnip mosaic virus
83. Biochemical and molecular characterization of three barley seed proteins with antifungal properties
84. Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31
85. Accumulation of jasmonate, abscisic acid, specific transcripts and proteins in osmotically stressed barley leaf segments
86. Molecular replacement studies of Trichosanthes kirilowii lectin 1: A structure belonging to the family of type 2 ribosome-inactivating proteins
87. Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro
88. Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein
89. Abrin and ricin: New anti-tumour substances
90. Cleavage of supercoiled double-stranded DNA by several ribosome-inactivating proteins in vitro
91. Topological requirements for recognition and cleavage of DNA by ribosome-inactivating proteins
92. Simultaneous existence of two types of ribosome-inactivating proteins in the seeds of Cinnamomum camphora - Characterization of the enzymatic activities of these cytotoxic proteins
93. Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand
94. Broad spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein
95. Expression of a barley ribosomeinactivating protein leads to increased fungal protection in transgenic tobacco plants
96. Ricin: Structure, mode of action, and some current applications
97. Tolerance to the fungal pathogen Rhizoctonia solani AG4 of transgenic tobacco expressing the maize ribosome-inactivating protein b-32
98. A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: Plants apparently contain a suicide system directed at ribosomes
99. Wheat ribosome-inactivating proteins: Seed and leaf forms with different specificities and cofactor requirements
100. GLQ223: An inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage
101. Ribosome-inactivating proteins
102. Raster3D photorealistic molecular graphics
103. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: Direct access to the cytosol
104. Structure of recombinant ricin A chain at 2.3 Å
105. Demonstration of ribonuclease activity in the plant ribosome-inactivating proteins alpha- and beta-momorcharins
106. Three-dimensional structure of ricin at 2.8 Å
107. X-ray analysis of substrate analogues in the ricin-A chain active site
108. The 2.5 A structure of pokeweed antiviral protein
109. Expression of a cDNA encoding Phytolacca insularis antiviral protein confers virus resistance on transgenic potato plants
110. Direct evidence for the deoxyribonuclease activity of the plant ribosome inactivating protein gelonin
111. An additional mechanism of ribosome-inactivating protein cytotoxicity: Degradation of extrachromosomal DNA
112. A new class of DNA glycosylase/apurinic/apyrimidinic lyases that act on specific adenines in single-stranded DNA
113. Gelonin is an unusual DNA glycosylase that removes adenine from single-stranded DNA, normal base pairs and mismatches
114. Maize ribosome-inactivating protein inhibits normal development of Aspergillus nidulans and Aspergillus flavus
115. A new class of enzyme acting on damaged ribosomes: Ribosomal RNA apurinic site specific lyase found in wheat germ
116. Crystallization of agglutinin from the seeds of Abrus precatorius
117. 2.8 Å crystal structure of a nontoxic type-II ribosome-inactivating proteins, ebulin I
118. Elderberry (Sambucus nigra) contains truncated Neu5Ac(α-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins
119. The galactose-binding and mannose-binding jacalin-related lectins are located in different sub-cellular compartments
120. Sequence and expression of the discoidin I gene family in Dictyostelium discoideum
121. Type-1 ribosome-inactivating proteins depurinate plant 25 S rRNA without species specificity
122. The food of sweet and bitter fancy
123. Deguanylation of human immunodeficiency virus (HIV)-1 RNA by recombinant pokeweed antiviral protein
124. Pokeweed antiviral protein isoforms PAP-I, PAP-II and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-I
125. Extracellular localization of pokeweed antiviral protein
126. JIPs and RIPs: The regulation of plant gene expression by jasmonates in response to environmental cues and pathogens
127. JIP60, a methyl jasmonate-induced ribosome-inactivating protein involved in plant stress reactions
128. Bifunctional plant defense enzymes with chitinase and ribosome-inactivating activities from Trichosanthes kirilowii cell cultures
129. The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin
130. Induction of a ribosome-inactivating protein upon environmental stress
131. Isolation and characterization of two antifungal proteins from barley
132. Ricin B chain and discoidin I share a common primitive protein fold
133. Structural analysis of ricin and implications for inhibitor design
134. DNA-nuclease activity of the single-chain ribosome-inactivating proteins dianthin 30, saporin 6 and gelonin
135. Structure and evolution of ricin B chain
136. Structure of Ricin B-chain at 2.5 Å resolution
137. Crystallographic refinement of ricin to 2.5 Å
138. Endocytosis and intracellular transport of ricin: Recent discoveries
139. Entry of ricin shiga toxin into cells: Molecular mechanisms medical perspectives
140. The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome
141. Expression of active, processed ricin in transgenic tobacco
142. Properties of a virus causing pokeweed mosaic
143. Expression of pokeweed antiviral protein in transgenic plants induces virus resistance in grafted wild-type plants independently of salicylic acid accumulation and pathogenesis-related protein synthesis
144. Systemic induction of a Phytolacca insularis antiviral protein gene by mechanical wounding, jasmonic acid, and abscisic acid
145. Identification of three oligosaccharide binding sites in ricin
146. Crystal structure of abrin-a at 2.14 Å
147. The CLUSTAL-X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tool
148. C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes
149. Pokeweed antiviral protein and its applications
150. Immunotoxins: An overview
151. Preparation of highly purified momordin II without ribonuclease activity
152. The NeuAc (α-(2,6)-Gal/GalNAc-binding lectin from elderberry (Sambucus nigra) bark, a type-2 ribosome-inactivating protein with an unusual specificity and structure
153. Characterization and molecular cloning of Sambucus nigra agglutinin V (nigrin b), a GalNAc-specific type-2 ribosome-inactivating protein from the bark of elderberry (Sambucus nigra)
154. Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: Characterization and molecular cloning
155. Isolation and molecular cloning of a novel type 2 ribosome-inactivating protein with an inactive B chain from elderberry (Sambucus nigra) bark
156. Elderberry (Sambucus nigra) bark contains two structurally different Neu5Ac (α2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins
157. The major elderberry (Sambucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome-inactivating protein
158. Plant lectins: A composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles
159. Characterization and molecular cloning of two different type 2 ribosome-inactivating proteins from the monocotyledonous plant Polygonatum multiflorum
160. Ricin A chain can be chemically cross-linked to the mammalian ribosomal proteins L9 and L10e
161. Characterization of two novel type I ribosome-inactivating proteins from the storage roots of the andean crop Mirabilis expansa
162. Characterization and molecular cloning of a proenzyme form of a ribosome-inactivating protein from maize. Novel mechanism of proenzyme activation by proteolytic removal of a 2.8-kilodalton internal peptide segment
163. Reduced toxicity and broad spectrum resistance to viral and fungal infection in transgenic plants expressing pokeweed antiviral protein II
164. Pokeweed antiviral protein cleaves double-stranded supercoiled DNA using the same active site required to depurinate rRNA
165. Solution structure of anti-HIV-1 and anti-tumor protein MAP30: Structural insights into its multiple functions
166. Virus resistance mediated by ribosome inactivating proteins
167. X-ray structure of recombinant ricin A-chain at 1.8 Å resolution
168. Crystal structure of trichosanthin-NADPH complex at 1.7 Å resolution reveals active-site architecture
169. Ricin D-saccharide interaction as studied by ultraviolet difference spectroscopy
170. Structure-based identification of a ricin inhibitor
171. Trichosanthin, alpha-momorcharin and beta-momorcharin: Identity of abortifacient and ribosome-inactivating proteins
172. Purification, characterization and subcellular localization of a type-1 ribosome-inactivating protein from the sarcocarp of Cucurbita pepo
173. Gypsophilin, a new type 1 ribosome-inactivating protein from Gypsophila elegans: Purification, enzymatic characterization, and subcellular localization
174. Three-dimensional structure of beta-momorcharin at 2.55 Å resolution
175. High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin
176. Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies
177. Toxicity of cinnamomin - A new type II ribosome-inactivating protein to bollworm and mosquito
178. Three-dimensional structures of acidic and basic fibroblast growth factors
179. Plant resistance to fungal infection induced by nontoxic pokeweed antiviral protein mutants
180. A non-toxic pokeweed antiviral protein mutant inhibits pathogen infection via a novel salicylic acid-independent pathway