5-Fluorouracil suppression of NF-kappa;B is mediated by the inhibition of Ikappa;B kinase activity in human salivary gland cancer cells

Biochemical and Biophysical Research Communications

Volumn 282, Issue 1, 2001, Pages 292-296

  Azuma, M ^a   Yamashita, T ^a   Aota, K ^a   Tamatani, T ^a   Sato, M ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

5 FU; Apoptosis; IKKs; MEKK 1; NF kappa; B; NIK; Salivary gland cancer cells

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 8; FLUOROURACIL; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PHOSPHOTRANSFERASE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SALIVARY GLAND CANCER;

EID: 0034815614     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4571     Document Type: Article

References (31)

1. Radiation therapy with 5-fluorouracil in head and neck cancer
2. Alterations of intratumoral pharmacokinetics of 5-fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy
3. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil
4. Rel/NF-kappa;B/Ikappa;B family: Intimate tales of association and dissociation
5. NF-kappa;B: Ten years after
6. Function and activation of NF-kappa;B in the immune system
7. The NF-kappa;B and Ikappa;B proteins: New discoveries and insights
8. Nuclear factor-kappa;B - A pivotal transcription factor in chronic inflammatory diseases
9. The beginning of the end: Ikappa;B kinase (IKK) and NF-kappa;B activation
10. An essential role for NF-kappa;B in preventing TNF-alpha;-induced cell death
11. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis, while NF-kappa;B activation prevents cell death
12. Suppression of TNF-alpha;-induced apoptosis by NF-kappa;B
13. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappa;B
14. A regulatory role for TRAF-1 in antigen-induced apoptosis of T cells
15. NF-kappa;B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
16. 5-Fluorouracil induces apoptosis through the suppression of NF-kappa;B activity in human salivary gland cancer cells
17. Role of plasminogen activators, metalloproteinases and the tissue inhibitor of metalloproteinase-1 in the metastatic process of human salivary gland adenocarcinoma cells
18. Tyrosine phosphorylation of Ikappa;B-alpha; activates NF-kappa;B without proteolytic degradation of Ikappa;B-alpha;
19. Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients
20. The Ikappa;B kinase complex (IKK) contains two kinase subunits, IKKalpha; and IKKbeta;, necessary for Ikappa;B phosphorylation and NF-kappa;B activation
21. The role of c-FLIP in modulation of CD95-induced apoptosis
22. Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis
23. Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug-resistant cells
24. dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: Association with survival and response to 5-fluorouracil in colorectal cancer
25. Fluorouracil: Biochemistry and pharmacology
26. IKKgamma; is an essential regulatory subunit of the IkappaB kinase complex
27. The anti-inflammatory agents aspirin and salicylate inhibit the activity of Ikappa;B kinase-beta;
28. Inhibition of fas death signals by FLIPs
29. Inhibition of death receptor signals by cellular FLIP
30. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
31. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis